4TNU
Human brain aspartoacylase mutant Y231C complex with intermediate analog (N-phosphonomethyl-L-aspartate)
Summary for 4TNU
Entry DOI | 10.2210/pdb4tnu/pdb |
Related | 2o4h |
Descriptor | Aspartoacylase, ZINC ION, N-[HYDROXY(METHYL)PHOSPHORYL]-L-ASPARTIC ACID, ... (4 entities in total) |
Functional Keywords | canavan disease, zinc-dependent hydrolase, aspartoacylase family, aminoacylase-2, n-acetyl-l-aspartate, hydrolase |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm: P45381 |
Total number of polymer chains | 2 |
Total formula weight | 72001.14 |
Authors | Wijayasinghe, Y.S.,Pavlovsky, A.G.,Viola, R.E. (deposition date: 2014-06-05, release date: 2014-07-30, Last modification date: 2023-09-27) |
Primary citation | Wijayasinghe, Y.S.,Pavlovsky, A.G.,Viola, R.E. Aspartoacylase catalytic deficiency as the cause of canavan disease: a structural perspective. Biochemistry, 53:4970-4978, 2014 Cited by PubMed: 25003821DOI: 10.1021/bi500719k PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.9 Å) |
Structure validation
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