4R54

Complex crystal structure of sp-Aspartate-Semialdehyde-Dehydrogenase with 3-carboxy-ethyl-phthalic acid

Summary for 4R54

Entry DOI	10.2210/pdb4r54/pdb
Related	4R3N 4R3W 4R41 4R4J 4R51 4R5H 4R5M
Descriptor	Aspartate-semialdehyde dehydrogenase, SODIUM ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (6 entities in total)
Functional Keywords	rossmann fold, oxidoreductase, nadp
Biological source	Streptococcus pneumoniae
Total number of polymer chains	2
Total formula weight	82732.51
Authors	Pavlovsky, A.G.,Viola, R.E. (deposition date: 2014-08-20, release date: 2014-12-10, Last modification date: 2023-09-20)
Primary citation	Pavlovsky, A.G.,Thangavelu, B.,Bhansali, P.,Viola, R.E. A cautionary tale of structure-guided inhibitor development against an essential enzyme in the aspartate-biosynthetic pathway. Acta Crystallogr.,Sect.D, 70:3244-3252, 2014 Cited by PubMed: 25478842 DOI: 10.1107/S1399004714023979 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.81 Å)

Structure validation