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PDB: 115 results

4O9X
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Crystal Structure of TcdB2-TccC3
Descriptor: MERCURY (II) ION, TcdB2, TccC3
Authors:Meusch, D, Gatsogiannis, C, Efremov, R.G, Lang, A.E, Hofnagel, O, Vetter, I.R, Aktories, K, Raunser, S.
Deposit date:2014-01-03
Release date:2014-02-26
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.17 Å)
Cite:Mechanism of Tc toxin action revealed in molecular detail.
Nature, 508, 2014
1V9D
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Crystal structure of the core FH2 domain of mouse mDia1
Descriptor: Diaphanous protein homolog 1, SULFATE ION
Authors:Shimada, A, Nyitrai, M, Vetter, I.R, Kuhlmann, D, Bugyi, B, Narumiya, S, Geeves, M.A, Wittinghofer, A.
Deposit date:2004-01-24
Release date:2004-03-09
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The core FH2 domain of diaphanous-related formins is an elongated actin binding protein that inhibits polymerization.
Mol.Cell, 13, 2004
1SRQ
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Crystal Structure of the Rap1GAP catalytic domain
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, GTPase-activating protein 1, SULFATE ION
Authors:Daumke, O, Weyand, M, Chakrabarti, P.P, Vetter, I.R, Wittinghofer, A.
Deposit date:2004-03-23
Release date:2004-05-25
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:The GTPase activating protein Rap1GAP uses a catalytic asparagine
Nature, 429, 2004
1A4R
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BU of 1a4r by Molmil
G12V MUTANT OF HUMAN PLACENTAL CDC42 GTPASE IN THE GDP FORM
Descriptor: AMINOPHOSPHONIC ACID-GUANYLATE ESTER, G25K GTP-BINDING PROTEIN, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Rudolph, M.G, Vetter, I.R, Wittinghofer, A.
Deposit date:1998-02-02
Release date:1999-03-02
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Nucleotide binding to the G12V-mutant of Cdc42 investigated by X-ray diffraction and fluorescence spectroscopy: two different nucleotide states in one crystal.
Protein Sci., 8, 1999
1S1C
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BU of 1s1c by Molmil
Crystal structure of the complex between the human RhoA and Rho-binding domain of human ROCKI
Descriptor: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Rho-associated, ...
Authors:Dvorsky, R, Blumenstein, L, Vetter, I.R, Ahmadian, M.R.
Deposit date:2004-01-06
Release date:2004-02-10
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural Insights into the Interaction of ROCKI with the Switch Regions of RhoA.
J.Biol.Chem., 279, 2004
3KUD
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Complex of Ras-GDP with RafRBD(A85K)
Descriptor: GTPase HRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Filchtinski, D, Sharabi, O, Rueppel, A, Vetter, I.R, Herrmann, C, Shifman, J.M.
Deposit date:2009-11-27
Release date:2010-03-23
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:What makes Ras an efficient molecular switch: a computational, biophysical, and structural study of Ras-GDP interactions with mutants of Raf.
J.Mol.Biol., 399, 2010
3KUC
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Complex of Rap1A(E30D/K31E)GDP with RafRBD(A85K/N71R)
Descriptor: CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Filchtinski, D, Sharabi, O, Rueppel, A, Vetter, I.R, Herrmann, C, Shifman, J.M.
Deposit date:2009-11-27
Release date:2010-03-23
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:What makes Ras an efficient molecular switch: a computational, biophysical, and structural study of Ras-GDP interactions with mutants of Raf.
J.Mol.Biol., 399, 2010
3L8Y
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Complex of Ras with cyclen
Descriptor: 1,4,7,10-tetraazacyclododecane, CALCIUM ION, GTPase HRas, ...
Authors:Rosnizeck, I.C, Graf, T, Spoerner, M, Traenkle, J, Filchtinski, D, Herrmann, C, Gremer, L, Vetter, I.R, Wittinghofer, A, Koenig, B, Kalbitzer, H.R.
Deposit date:2010-01-04
Release date:2011-01-05
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Stabilizing a weak binding state for effectors in the human ras protein by cyclen complexes
Angew.Chem.Int.Ed.Engl., 49, 2010
3LVQ
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The crystal structure of ASAP3 in complex with Arf6 in transition state
Descriptor: ALUMINUM FLUORIDE, Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3, ...
Authors:Ismail, S.A, Vetter, I.R, Sot, B, Wittinghofer, A.
Deposit date:2010-02-22
Release date:2010-06-09
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (3.38 Å)
Cite:The structure of an Arf-ArfGAP complex reveals a Ca2+ regulatory mechanism
Cell(Cambridge,Mass.), 141, 2010
3L8Z
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H-Ras wildtype new crystal form
Descriptor: CALCIUM ION, GTPase HRas, MAGNESIUM ION, ...
Authors:Rosnizeck, I.C, Graf, T, Spoerner, M, Traenkle, J, Filchtinski, D, Herrmann, C, Gremer, L, Vetter, I.R, Wittinghofer, A, Koenig, B, Kalbitzer, H.R.
Deposit date:2010-01-04
Release date:2011-01-05
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.44 Å)
Cite:Stabilizing a weak binding state for effectors in the human ras protein by cyclen complexes
Angew.Chem.Int.Ed.Engl., 49, 2010
4I1O
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BU of 4i1o by Molmil
Crystal structure of the Legionella pneumophila GAP domain of LepB in complex with Rab1b bound to GDP and BeF3
Descriptor: BERYLLIUM TRIFLUORIDE ION, DI(HYDROXYETHYL)ETHER, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Gazdag, E.M, Streller, A, Vetter, I.R, Goody, R.S, Itzen, A.
Deposit date:2012-11-21
Release date:2013-01-16
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.701 Å)
Cite:Mechanism of Rab1b deactivation by the Legionella pneumophila GAP LepB.
Embo Rep., 14, 2013
4I1M
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Crystal structure of the Legionella pneumophila GAP domain of LepB
Descriptor: DI(HYDROXYETHYL)ETHER, LepB
Authors:Streller, A, Gazdag, E.M, Vetter, I.R, Goody, R.S, Itzen, A.
Deposit date:2012-11-21
Release date:2013-01-16
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.804 Å)
Cite:Mechanism of Rab1b deactivation by the Legionella pneumophila GAP LepB.
Embo Rep., 14, 2013
8A4C
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BU of 8a4c by Molmil
Structure of human Rep15:Rab3B complex.
Descriptor: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Rab15 effector protein, ...
Authors:Rai, A, Vetter, I.R, Goody, R.S.
Deposit date:2022-06-10
Release date:2022-08-10
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Rep15 interacts with several Rab GTPases and has a distinct fold for a Rab effector.
Nat Commun, 13, 2022
8A4B
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Structure of human Rep15:Rab3B_Q81L complex.
Descriptor: GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Rab15 effector protein, ...
Authors:Rai, A, Vetter, I.R, Goody, R.S.
Deposit date:2022-06-10
Release date:2022-08-10
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Rep15 interacts with several Rab GTPases and has a distinct fold for a Rab effector.
Nat Commun, 13, 2022
8A4A
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BU of 8a4a by Molmil
Structure of human Rep15 in complex with bovine Rab3C.
Descriptor: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Rab15 effector protein, ...
Authors:Rai, A, Vetter, I.R, Goody, R.S.
Deposit date:2022-06-10
Release date:2022-08-10
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.52 Å)
Cite:Rep15 interacts with several Rab GTPases and has a distinct fold for a Rab effector.
Nat Commun, 13, 2022
1M7B
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BU of 1m7b by Molmil
Crystal structure of Rnd3/RhoE: functional implications
Descriptor: GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Rnd3/RhoE small GTP-binding protein
Authors:Fiegen, D, Blumenstein, L, Stege, P, Vetter, I.R, Ahmadian, M.R.
Deposit date:2002-07-19
Release date:2002-08-07
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of Rnd3/RhoE: functional implications
FEBS LETT., 525, 2002
1M5I
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BU of 1m5i by Molmil
Crystal Structure of the coiled coil region 129-250 of the tumor suppressor gene product APC
Descriptor: APC protein
Authors:Tickenbrock, L, Cramer, J, Vetter, I.R, Mueller, O.
Deposit date:2002-07-09
Release date:2002-11-20
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:The coiled coil region (amino acids 129-250) of the tumor suppressor protein adenomatous polyposis coli (APC). Its structure and its interaction with chromosome maintenance region 1 (Crm-1).
J.Biol.Chem., 277, 2002
7QPG
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BU of 7qpg by Molmil
Human RZZ kinetochore corona complex.
Descriptor: Centromere/kinetochore protein zw10 homolog, Kinetochore-associated protein 1, Protein zwilch homolog
Authors:Raisch, T, Ciossani, G, d'Amico, E, Cmetowski, V, Carmignani, S, Maffini, S, Merino, F, Wohlgemuth, S, Vetter, I.R, Raunser, S, Musacchio, A.
Deposit date:2022-01-04
Release date:2022-03-16
Last modified:2024-07-17
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Structure of the RZZ complex and molecular basis of Spindly-driven corona assembly at human kinetochores.
Embo J., 41, 2022
4F0G
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BU of 4f0g by Molmil
Crystal Structure of the Roco4 Kinase Domain from D. discoideum
Descriptor: Serine/threonine-protein kinase roco4
Authors:Gilsbach, B.K, Vetter, I.R, Wittinghofer, A, Kortholt, A.
Deposit date:2012-05-04
Release date:2012-06-27
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Roco kinase structures give insights into the mechanism of Parkinson disease-related leucine-rich-repeat kinase 2 mutations.
Proc.Natl.Acad.Sci.USA, 109, 2012
4F0F
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BU of 4f0f by Molmil
Crystal Structure of the Roco4 Kinase Domain bound to AppCp from D. discoideum
Descriptor: PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, Serine/threonine-protein kinase roco4
Authors:Gilsbach, B.K, Vetter, I.R, Wittinghofer, A, Kortholt, A.
Deposit date:2012-05-04
Release date:2012-06-27
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Roco kinase structures give insights into the mechanism of Parkinson disease-related leucine-rich-repeat kinase 2 mutations.
Proc.Natl.Acad.Sci.USA, 109, 2012
4F1M
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Crystal Structure of the G1179S Roco4 Kinase Domain bound to AppCp from D. discoideum.
Descriptor: 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ...
Authors:Gilsbach, B.K, Vetter, I.R, Wittinghofer, A, Kortholt, A.
Deposit date:2012-05-07
Release date:2012-06-27
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Roco kinase structures give insights into the mechanism of Parkinson disease-related leucine-rich-repeat kinase 2 mutations.
Proc.Natl.Acad.Sci.USA, 109, 2012
4F1O
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BU of 4f1o by Molmil
Crystal Structure of the L1180T mutant Roco4 Kinase Domain from D. discoideum bound to AppCp
Descriptor: PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, Serine/threonine-protein kinase roco4
Authors:Gilsbach, B.K, Vetter, I.R, Wittinghofer, A, Kortholt, A.
Deposit date:2012-05-07
Release date:2012-06-27
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Roco kinase structures give insights into the mechanism of Parkinson disease-related leucine-rich-repeat kinase 2 mutations.
Proc.Natl.Acad.Sci.USA, 109, 2012
4F1T
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Crystal Structure of the Roco4 Kinase Domain from D. discoideum bound to the ROCK Inhibitor H1152
Descriptor: (S)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLINE)SULFONYL]-HOMOPIPERAZINE, Serine/threonine-protein kinase roco4
Authors:Gilsbach, B.K, Vetter, I.R, Wittinghofer, A, Kortholt, A.
Deposit date:2012-05-07
Release date:2012-06-27
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Roco kinase structures give insights into the mechanism of Parkinson disease-related leucine-rich-repeat kinase 2 mutations.
Proc.Natl.Acad.Sci.USA, 109, 2012
6EQT
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BU of 6eqt by Molmil
CRYSTAL STRUCTURE OF THE HUMAN KINETOCHORE PROTEIN CENP-N
Descriptor: Centromere protein N
Authors:Pentakota, S, Vetter, I.R, Petrovic, A, Musacchio, A.
Deposit date:2017-10-15
Release date:2018-01-17
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.735 Å)
Cite:Decoding the centromeric nucleosome through CENP-N.
Elife, 6, 2017
6EZT
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BU of 6ezt by Molmil
Crystal structure of GH20 Exo beta-N-Acetylglucosaminidase D437A inactive mutant from Vibrio harveyi
Descriptor: Beta-N-acetylglucosaminidase Nag2, DI(HYDROXYETHYL)ETHER, TETRAETHYLENE GLYCOL
Authors:Porfetye, A.T, Meekrathok, P, Burger, M, Vetter, I.R, Suginta, W.
Deposit date:2017-11-16
Release date:2018-12-12
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure of GH20 Exo beta-N-Acetylglucosaminidase from Vibrio harveyi
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