4F0F

Crystal Structure of the Roco4 Kinase Domain bound to AppCp from D. discoideum

Summary for 4F0F

Entry DOI	10.2210/pdb4f0f/pdb
Related	4F0G 4F1M 4F1O 4F1T
Descriptor	Serine/threonine-protein kinase roco4, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER (3 entities in total)
Functional Keywords	protein kinase, lrrk2, roco, kinase, atp-binding, nucleotide-binding, serine/threonine-protein kinase, transferase, signaling protein
Biological source	Dictyostelium discoideum (Slime mold)
Total number of polymer chains	1
Total formula weight	33121.75
Authors	Gilsbach, B.K.,Vetter, I.R.,Wittinghofer, A.,Kortholt, A. (deposition date: 2012-05-04, release date: 2012-06-27, Last modification date: 2023-09-13)
Primary citation	Gilsbach, B.K.,Ho, F.Y.,Vetter, I.R.,van Haastert, P.J.,Wittinghofer, A.,Kortholt, A. Roco kinase structures give insights into the mechanism of Parkinson disease-related leucine-rich-repeat kinase 2 mutations. Proc.Natl.Acad.Sci.USA, 109:10322-10327, 2012 Cited by PubMed: 22689969 DOI: 10.1073/pnas.1203223109 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation