4I1O

Crystal structure of the Legionella pneumophila GAP domain of LepB in complex with Rab1b bound to GDP and BeF3

Summary for 4I1O

• Entry DOI: 10.2210/pdb4i1o/pdb
• Related: 4I1M
• Descriptor: Ras-related protein Rab-1B, LepB, MAGNESIUM ION, ... (7 entities in total)
• Functional Keywords: gap, rabgap, hydrolase activator, rab1b, lpg2490, gtpase-activating proteins, hydrolysis, rab1 hydrolase, gtp hydrolase, protein transport-hydrolase complex, protein transport/hydrolase
• Biological source: Homo sapiens (human); More
• Cellular location: Membrane; Lipid-anchor; Cytoplasmic side: Q9H0U4
• Total number of polymer chains: 8
• Total formula weight: 221227.36

Authors

Gazdag, E.M.,Streller, A.,Vetter, I.R.,Goody, R.S.,Itzen, A. (deposition date: 2012-11-21, release date: 2013-01-16, Last modification date: 2023-09-20)

• Primary citation: Mihai Gazdag, E.,Streller, A.,Haneburger, I.,Hilbi, H.,Vetter, I.R.,Goody, R.S.,Itzen, A.; Mechanism of Rab1b deactivation by the Legionella pneumophila GAP LepB.; Embo Rep., 14:199-205, 2013; PubMed: 23288104; DOI: 10.1038/embor.2012.211

Experimental method

X-RAY DIFFRACTION (2.701 Å)