Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4I1O

Crystal structure of the Legionella pneumophila GAP domain of LepB in complex with Rab1b bound to GDP and BeF3

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003924	molecular_function	GTPase activity
A	0005525	molecular_function	GTP binding
C	0003924	molecular_function	GTPase activity
C	0005525	molecular_function	GTP binding
E	0003924	molecular_function	GTPase activity
E	0005525	molecular_function	GTP binding
G	0003924	molecular_function	GTPase activity
G	0005525	molecular_function	GTP binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 201

Chain	Residue
A	SER22
A	THR40
A	ASP63
A	GDP202
A	BEF203
A	HOH306

site_id	AC2
Number of Residues	22
Details	BINDING SITE FOR RESIDUE GDP A 202

Chain	Residue
A	LYS21
A	SER22
A	CYS23
A	TYR33
A	ILE38
A	ASN121
A	LYS122
A	ASP124
A	LEU125
A	SER151
A	ALA152
A	LYS153
A	MG201
A	BEF203
A	PEG204
A	HOH303
A	HOH306
A	HOH309
D	ARG444
A	GLY18
A	VAL19
A	GLY20

site_id	AC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE BEF A 203

Chain	Residue
A	SER17
A	GLY18
A	LYS21
A	SER39
A	THR40
A	GLY66
A	MG201
A	GDP202
D	ARG444

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PEG A 204

Chain	Residue
A	TYR33
A	GLU35
A	LYS153
A	GDP202

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG C 201

Chain	Residue
C	SER22
C	THR40
C	GDP202
C	BEF203
C	HOH304

site_id	AC6
Number of Residues	22
Details	BINDING SITE FOR RESIDUE GDP C 202

Chain	Residue
B	ARG444
C	GLY18
C	VAL19
C	GLY20
C	LYS21
C	SER22
C	CYS23
C	TYR33
C	TYR37
C	ASN121
C	LYS122
C	ASP124
C	LEU125
C	SER151
C	ALA152
C	LYS153
C	MG201
C	BEF203
C	PEG204
C	HOH304
C	HOH308
C	HOH312

site_id	AC7
Number of Residues	8
Details	BINDING SITE FOR RESIDUE BEF C 203

Chain	Residue
B	ARG444
C	SER17
C	GLY18
C	LYS21
C	SER39
C	THR40
C	MG201
C	GDP202

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PEG C 204

Chain	Residue
C	TYR33
C	GLU35
C	TYR37
C	GDP202

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PEG C 205

Chain	Residue
B	ASN441
B	LYS482
C	THR40
C	ASP44

site_id	BC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PEG C 206

Chain	Residue
C	LYS10
C	SER76
C	TYR77
C	TYR78
C	ARG79
C	GLY80

site_id	BC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PEG D 701

Chain	Residue
D	LEU562
D	LYS606

site_id	BC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG E 201

Chain	Residue
E	SER22
E	THR40
E	GDP202
E	BEF203
E	HOH306

site_id	BC4
Number of Residues	20
Details	BINDING SITE FOR RESIDUE GDP E 202

Chain	Residue
E	GLY20
E	LYS21
E	SER22
E	CYS23
E	TYR33
E	ILE38
E	ASN121
E	LYS122
E	ASP124
E	LEU125
E	SER151
E	ALA152
E	LYS153
E	MG201
E	BEF203
E	HOH306
F	ARG444
F	HOH721
E	GLY18
E	VAL19

site_id	BC5
Number of Residues	11
Details	BINDING SITE FOR RESIDUE BEF E 203

Chain	Residue
E	SER17
E	GLY18
E	SER22
E	SER39
E	THR40
E	ALA65
E	GLY66
E	MG201
E	GDP202
E	HOH306
F	ARG444

site_id	BC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG G 201

Chain	Residue
G	SER22
G	THR40
G	GDP202
G	BEF203
G	HOH307

site_id	BC7
Number of Residues	21
Details	BINDING SITE FOR RESIDUE GDP G 202

Chain	Residue
G	GLY18
G	GLY20
G	LYS21
G	SER22
G	CYS23
G	TYR33
G	TYR37
G	THR40
G	ASN121
G	LYS122
G	ASP124
G	LEU125
G	SER151
G	ALA152
G	LYS153
G	MG201
G	BEF203
G	PEG204
G	HOH307
G	HOH313
H	ARG444

site_id	BC8
Number of Residues	9
Details	BINDING SITE FOR RESIDUE BEF G 203

Chain	Residue
G	SER17
G	GLY18
G	LYS21
G	SER39
G	THR40
G	GLY66
G	MG201
G	GDP202
H	ARG444

site_id	BC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PEG G 204

Chain	Residue
G	GLU35
G	LEU125
G	LYS153
G	GDP202

Functional Information from PROSITE/UniProt

site_id	PS00675
Number of Residues	14
Details	SIGMA54_INTERACT_1 Sigma-54 interaction domain ATP-binding region A signature. LLLiGDSGVGKscL

Chain	Residue	Details
A	LEU11-LEU24

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	76
Details	Region: {"description":"Switch 2 region; required for interaction with REP1/CHM"}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	60
Details	Motif: {"description":"Switch 1","evidences":[{"source":"PubMed","id":"20064470","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3JZA","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	60
Details	Motif: {"description":"Switch 2","evidences":[{"source":"PubMed","id":"20064470","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3JZA","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	40
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20651120","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27552051","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3NKV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SZH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SZK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27552051","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5SZH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SZK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PDB","id":"3NKV","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20651120","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23236136","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27552051","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3NKV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4HLQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4I1O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SZH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SZK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27552051","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5SZH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20651120","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3NKV","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"23236136","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27552051","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4HLQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SZH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27552051","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5SZK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	4
Details	Modified residue: {"description":"(Microbial infection) O-(2-cholinephosphoryl)serine","evidences":[{"source":"PubMed","id":"21822290","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22158903","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22307087","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	4
Details	Modified residue: {"description":"(Microbial infection) O-AMP-tyrosine","evidences":[{"source":"PubMed","id":"20651120","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)