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PDB: 24 件
9BEI
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BU of 9bei by Molmil
Cryo-EM structure of synthetic claudin-4 complex with Clostridium perfringens enterotoxin C-terminal domain, sFab COP-2, and Nanobody
分子名称: Anti-fab nanobody, COP-2 Fab Heavy chain, COP-2 Fab Light chain, ...
著者Vecchio, A.J.
登録日2024-04-15
公開日2024-04-24
最終更新日2024-07-24
実験手法ELECTRON MICROSCOPY (4.16 Å)
主引用文献Computational design of soluble and functional membrane protein analogues.
Nature, 631, 2024
7TDM
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BU of 7tdm by Molmil
CryoEM Structure of sFab COP-2 Complex with human claudin-4 and Clostridium perfringens enterotoxin C-terminal domain
分子名称: COP-2 Fab Heavy chain, COP-2 Fab Light chain, Claudin-4, ...
著者Vecchio, A.J.
登録日2022-01-01
公開日2022-02-09
最終更新日2024-01-17
実験手法ELECTRON MICROSCOPY (6.9 Å)
主引用文献Development, structure, and mechanism of synthetic antibodies that target claudin and Clostridium perfringens enterotoxin complexes.
J.Biol.Chem., 298, 2022
7TDN
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BU of 7tdn by Molmil
CryoEM Structure of sFab COP-3 Complex with human claudin-4 and Clostridium perfringens enterotoxin C-terminal domain
分子名称: COP-3 Fab Heavy chain, COP-3 Fab Light chain, Claudin-4, ...
著者Vecchio, A.J.
登録日2022-01-01
公開日2022-02-09
最終更新日2024-01-17
実験手法ELECTRON MICROSCOPY (5 Å)
主引用文献Development, structure, and mechanism of synthetic antibodies that target claudin and Clostridium perfringens enterotoxin complexes.
J.Biol.Chem., 298, 2022
9CMI
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BU of 9cmi by Molmil
Cryo-EM structure of human claudin-4 complex with Clostridium perfringens enterotoxin, sFab COP-1, and Nanobody
分子名称: Anti-Fab Nanobody, COP-1 sFab Heavy Chain, COP-1 sFab Light Chain, ...
著者Vecchio, A.J.
登録日2024-07-15
公開日2024-08-07
実験手法ELECTRON MICROSCOPY (2.83 Å)
主引用文献Cryo-EM Structures of Clostridium perfringens Enterotoxin Bound to its Human Receptor, Claudin-4
To Be Published
9CMH
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BU of 9cmh by Molmil
Cryo-EM structure of human claudin-4 complex with Clostridium perfringens enterotoxin
分子名称: Claudin-4, Heat-labile enterotoxin B chain
著者Vecchio, A.J.
登録日2024-07-15
公開日2024-07-24
実験手法ELECTRON MICROSCOPY (4 Å)
主引用文献Cryo-EM Structures of Clostridium perfringens Enterotoxin Bound to its Human Receptor, Claudin-4
To Be Published
3TZI
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BU of 3tzi by Molmil
X-ray crystal structure of arachidonic acid bound in the cyclooxygenase channel of G533V murine COX-2
分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Vecchio, A.J, Malkowski, M.G.
登録日2011-09-27
公開日2012-04-25
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Investigating Substrate Promiscuity in Cyclooxygenase-2: THE ROLE OF ARG-120 AND RESIDUES LINING THE HYDROPHOBIC GROOVE.
J.Biol.Chem., 287, 2012
4E1G
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BU of 4e1g by Molmil
X-ray crystal structure of alpha-linolenic acid bound to the cyclooxygenase channel of cyclooxygenase-2
分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Vecchio, A.J, Malkowski, M.G.
登録日2012-03-06
公開日2012-04-25
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Investigating Substrate Promiscuity in Cyclooxygenase-2: THE ROLE OF ARG-120 AND RESIDUES LINING THE HYDROPHOBIC GROOVE.
J.Biol.Chem., 287, 2012
7KP4
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BU of 7kp4 by Molmil
Crystal structure of human claudin-4 in complex with Clostridium perfringens enterotoxin C-terminal domain
分子名称: Claudin-4, Heat-labile enterotoxin B chain
著者Vecchio, A.J, Stroud, R.M.
登録日2020-11-10
公開日2020-12-09
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.37 Å)
主引用文献Structural basis for Clostridium perfringens enterotoxin targeting of claudins at tight junctions in mammalian gut.
Proc.Natl.Acad.Sci.USA, 118, 2021
8U5B
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BU of 8u5b by Molmil
Cryo-EM structure of human claudin-4 complex with Clostridium perfringens enterotoxin C-terminal domain and sFab COP-1
分子名称: COP-1 sFab Heavy Chain, COP-1 sFab Light Chain, Claudin-4, ...
著者Vecchio, A.J.
登録日2023-09-12
公開日2023-09-27
最終更新日2024-07-03
実験手法ELECTRON MICROSCOPY (5.3 Å)
主引用文献Structural and biophysical insights into targeting of claudin-4 by a synthetic antibody fragment.
Commun Biol, 7, 2024
8U4V
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BU of 8u4v by Molmil
Cryo-EM structure of human claudin-4 complex with Clostridium perfringens enterotoxin C-terminal domain, sFab COP-1, and Nanobody
分子名称: Anti-fab nanobody, COP-1 sFab Heavy Chain, COP-1 sFab Light Chain, ...
著者Vecchio, A.J.
登録日2023-09-11
公開日2023-10-25
最終更新日2024-07-03
実験手法ELECTRON MICROSCOPY (2.99 Å)
主引用文献Structural and biophysical insights into targeting of claudin-4 by a synthetic antibody fragment.
Commun Biol, 7, 2024
3KRK
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BU of 3krk by Molmil
X-ray crystal structure of arachidonic acid bound in the cyclooxygenase channel of L531F murine COX-2
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ACRYLIC ACID, ...
著者Vecchio, A.J, Simmons, D.M, Malkowski, M.G.
登録日2009-11-18
公開日2010-05-12
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structural basis of fatty acid substrate binding to cyclooxygenase-2.
J.Biol.Chem., 285, 2010
3MDL
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BU of 3mdl by Molmil
X-ray crystal structure of 1-arachidonoyl glycerol bound to the cyclooxygenase channel of cyclooxygenase-2
分子名称: (2S)-2,3-dihydroxypropyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Vecchio, A.J, Malkowski, M.G.
登録日2010-03-30
公開日2011-04-13
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献The structural basis of endocannabinoid oxygenation by cyclooxygenase-2.
J.Biol.Chem., 286, 2011
6OV3
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BU of 6ov3 by Molmil
Crystal structure of human claudin-9 in complex with Clostridium perfringens entertoxin C-terminal domain in open form
分子名称: Claudin-9, Heat-labile enterotoxin B chain
著者Vecchio, A.J, Stroud, R.M.
登録日2019-05-06
公開日2019-09-04
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3.25 Å)
主引用文献Claudin-9 structures reveal mechanism for toxin-induced gut barrier breakdown.
Proc.Natl.Acad.Sci.USA, 116, 2019
6OV2
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BU of 6ov2 by Molmil
Crystal structure of human claudin-9 in complex with Clostridium perfringens entertoxin C-terminal domain in closed form
分子名称: Claudin-9, GLYCEROL, Heat-labile enterotoxin B chain
著者Vecchio, A.J, Stroud, R.M.
登録日2019-05-06
公開日2019-09-04
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Claudin-9 structures reveal mechanism for toxin-induced gut barrier breakdown.
Proc.Natl.Acad.Sci.USA, 116, 2019
3HS7
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BU of 3hs7 by Molmil
X-ray crystal structure of docosahexaenoic acid bound to the cyclooxygenase channel of cyclooxygenase-2
分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Vecchio, A.J, Simmons, D.M, Malkowski, M.G.
登録日2009-06-10
公開日2010-05-12
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Structural basis of fatty acid substrate binding to cyclooxygenase-2.
J.Biol.Chem., 285, 2010
3HS6
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BU of 3hs6 by Molmil
X-ray crystal structure of eicosapentaenoic acid bound to the cyclooxygenase channel of cyclooxygenase-2
分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Vecchio, A.J, Simmons, D.M, Malkowski, M.G.
登録日2009-06-10
公開日2010-05-12
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structural basis of fatty acid substrate binding to cyclooxygenase-2.
J.Biol.Chem., 285, 2010
3HS5
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BU of 3hs5 by Molmil
X-ray crystal structure of arachidonic acid bound to the cyclooxygenase channel of cyclooxygenase-2
分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Vecchio, A.J, Simmons, D.M, Malkowski, M.G.
登録日2009-06-10
公開日2010-05-12
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural basis of fatty acid substrate binding to cyclooxygenase-2.
J.Biol.Chem., 285, 2010
3OLT
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BU of 3olt by Molmil
X-ray crystal structure of arachidonic acid bound to the cyclooxygenase channel of R513H murine COX-2
分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Vecchio, A.J, Malkowski, M.G.
登録日2010-08-26
公開日2011-04-13
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献The structural basis of endocannabinoid oxygenation by cyclooxygenase-2.
J.Biol.Chem., 286, 2011
3QMO
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BU of 3qmo by Molmil
X-ray crystal structure of NS-398 bound to the cyclooxygenase channel of cyclooxygenase-2
分子名称: 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Vecchio, A.J, Malkowski, M.G.
登録日2011-02-04
公開日2011-08-03
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献The structure of NS-398 bound to cyclooxygenase-2.
J.Struct.Biol., 176, 2011
3QH0
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BU of 3qh0 by Molmil
X-ray crystal structure of palmitic acid bound to the cyclooxygenase channel of cyclooxygenase-2
分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Vecchio, A.J, Malkowski, M.G.
登録日2011-01-25
公開日2011-04-13
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Human cyclooxygenase-2 is a sequence homodimer that functions as a conformational heterodimer.
J.Biol.Chem., 286, 2011
3OLU
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BU of 3olu by Molmil
X-ray crystal structure of 1-arachidonoyl glycerol bound to the cyclooxygenase channel of R513H murine COX-2
分子名称: (2S)-2,3-dihydroxypropyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Vecchio, A.J, Malkowski, M.G.
登録日2010-08-26
公開日2011-04-13
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献The structural basis of endocannabinoid oxygenation by cyclooxygenase-2.
J.Biol.Chem., 286, 2011
8U5F
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BU of 8u5f by Molmil
Crystal Structure of Trypsinized Clostridium perfringens Enterotoxin
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLYCEROL, Heat-labile enterotoxin B chain, ...
著者Kapoor, S, Ogbu, C.P, Vecchio, A.J.
登録日2023-09-12
公開日2023-09-27
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.32 Å)
主引用文献Structural Basis of Clostridium perfringens Enterotoxin Activation and Oligomerization by Trypsin.
Toxins, 15, 2023
8U5E
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BU of 8u5e by Molmil
Crystal Structure of C-terminal domain of Clostridium perfringens Enterotoxin in Space Group P 21 21 21
分子名称: ACETATE ION, GLYCEROL, Heat-labile enterotoxin B chain, ...
著者Kapoor, S, Vecchio, A.J.
登録日2023-09-12
公開日2023-12-20
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Structural Basis of Clostridium perfringens Enterotoxin Activation and Oligomerization by Trypsin.
Toxins, 15, 2023
8U5D
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BU of 8u5d by Molmil
Crystal Structure of C-terminal domain of Clostridium perfringens Enterotoxin in Space Group P 41 21 2
分子名称: ACETATE ION, GLYCEROL, Heat-labile enterotoxin B chain, ...
著者Kapoor, S, Vecchio, A.J.
登録日2023-09-12
公開日2023-12-20
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Structural Basis of Clostridium perfringens Enterotoxin Activation and Oligomerization by Trypsin.
Toxins, 15, 2023

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件を2024-09-11に公開中

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