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PDB: 79 results

5EQL
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BU of 5eql by Molmil
Isoform-specific inhibition of SUMO-dependent protein-protein interactions
Descriptor: SUMO-Affirmer-S2D5, Small ubiquitin-related modifier 2
Authors:Hughes, D.J, Tiede, C, Hall, N, Tang, A.A.S, Trinh, C.H, Zajac, K, Mandal, U, Howell, G, Edwards, T.A, McPherson, M.J, Tomlinson, D.C, Whitehouse, A.
Deposit date:2015-11-13
Release date:2016-11-23
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.49 Å)
Cite:Generation of specific inhibitors of SUMO-1- and SUMO-2/3-mediated protein-protein interactions using Affimer (Adhiron) technology.
Sci Signal, 10, 2017
5ELJ
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BU of 5elj by Molmil
Isoform-specific inhibition of SUMO-dependent protein-protein interactions
Descriptor: SUMO-Affirmer-S2D5, Small ubiquitin-related modifier 1
Authors:Hughes, D.J, Tiede, C, Hall, N, Tang, A.A.S, Trinh, C.H, Zajac, K, Mandal, U, Howell, G, Edwards, T.A, McPherson, M.J, Tomlinson, D.C, Whitehouse, A.
Deposit date:2015-11-04
Release date:2016-11-16
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.983 Å)
Cite:Generation of specific inhibitors of SUMO-1- and SUMO-2/3-mediated protein-protein interactions using Affimer (Adhiron) technology.
Sci Signal, 10, 2017
5ELU
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BU of 5elu by Molmil
Isoform-specific inhibition of SUMO-dependent protein-protein interactions
Descriptor: SULFATE ION, SUMO-Affirmer-S2B3, Small ubiquitin-related modifier 2
Authors:Hughes, D.J, Tiede, C, Hall, N, Tang, A.A.S, Trinh, C.H, Zajac, K, Mandal, U, Howell, G, Edwards, T.A, McPherson, M.J, Tomlinson, D.C, Whitehouse, A.
Deposit date:2015-11-05
Release date:2016-11-16
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Generation of specific inhibitors of SUMO-1- and SUMO-2/3-mediated protein-protein interactions using Affimer (Adhiron) technology.
Sci Signal, 10, 2017
2YIU
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BU of 2yiu by Molmil
X-ray structure of the dimeric cytochrome BC1 complex from the soil bacterium paracoccus denitrificans at 2.7 angstrom resolution
Descriptor: CYTOCHROME B, CYTOCHROME C1, HEME PROTEIN, ...
Authors:Kleinschroth, T, Castellani, M, Trinh, C.H, Morgner, N, Brutschy, B, Ludwig, B, Hunte, C.
Deposit date:2011-05-16
Release date:2011-10-26
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:X-Ray Structure of the Dimeric Cytochrome Bc(1) Complex from the Soil Bacterium Paracoccus Denitrificans at 2.7-A Resolution.
Biochim.Biophys.Acta, 1807, 2011
5ZZ1
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BU of 5zz1 by Molmil
Probing the active center of catalase-phenol oxidase from Scytalidium thermophilum
Descriptor: 3-AMINO-1,2,4-TRIAZOLE, CALCIUM ION, CIS-HEME D HYDROXYCHLORIN GAMMA-SPIROLACTONE, ...
Authors:Yuzugullu Karakus, Y, Trinh, C.H, Pearson, A.R, Ogel, Z.B, McPherson, M.J.
Deposit date:2018-05-29
Release date:2019-05-29
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:Identification of the site of oxidase substrate binding in Scytalidium thermophilum catalase.
Acta Crystallogr D Struct Biol, 74, 2018
4AHO
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BU of 4aho by Molmil
Crystal Structure of N-acetylneuraminic acid lyase from Staphylococcus aureus with the chemical modification thia-lysine at position 165
Descriptor: CHLORIDE ION, N-ACETYLNEURAMINATE LYASE
Authors:Timms, N, Polyakova, A, Windle, C.L, Trinh, C.H, Nelson, A, Trinh, A.R, Berry, A.
Deposit date:2012-02-06
Release date:2013-01-23
Last modified:2013-03-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Insights Into the Recovery of Aldolase Activity in N-Acetylneuraminic Acid Lyase by Replacement of the Catalytically Active Lysine with Gamma-Thialysine by Using a Chemical Mutagenesis Strategy.
Chembiochem, 14, 2013
6STJ
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BU of 6stj by Molmil
Selective Affimers Recognize BCL-2 Family Proteins Through Non-Canonical Structural Motifs
Descriptor: Cystatin domain-containing protein, Induced myeloid leukemia cell differentiation protein Mcl-1
Authors:Hobor, F, Miles, J.A, Trinh, C.H, Taylor, J, Tiede, C, Rowell, P.R, Jackson, B, Nadat, F, Kyle, H.F, Wicky, B.I.M, Clarke, J, Tomlinson, D.C, Wilson, A.J, Edwards, T.A.
Deposit date:2019-09-10
Release date:2020-09-30
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Selective Affimers Recognise the BCL-2 Family Proteins BCL-x L and MCL-1 through Noncanonical Structural Motifs*.
Chembiochem, 22, 2021
6ST2
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BU of 6st2 by Molmil
Selective Affimers Recognize BCL-2 Family Proteins Through Non-Canonical Structural Motifs
Descriptor: Affimer AF6, Bcl-2-like protein 1, SULFATE ION
Authors:Hobor, F, Miles, J.A, Trinh, C.H, Taylor, J, Tiede, C, Rowell, P.R, Jackson, B, Nadat, F, Kyle, H.F, Wicky, B.I.M, Clarke, J, Tomlinson, D.C, Wilson, A.J, Edwards, T.A.
Deposit date:2019-09-09
Release date:2020-09-30
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Selective Affimers Recognise the BCL-2 Family Proteins BCL-x L and MCL-1 through Noncanonical Structural Motifs*.
Chembiochem, 22, 2021
4AHQ
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BU of 4ahq by Molmil
Crystal Structure of N-acetylneuraminic acid lyase mutant K165C from Staphylococcus aureus
Descriptor: N-ACETYLNEURAMINATE LYASE
Authors:Timms, N, Polyakova, A, Windle, C.L, Trinh, C.H, Nelson, A, Trinh, A.R, Berry, A.
Deposit date:2012-02-06
Release date:2013-01-23
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural Insights Into the Recovery of Aldolase Activity in N-Acetylneuraminic Acid Lyase by Replacement of the Catalytically Active Lysine with Gamma-Thialysine by Using a Chemical Mutagenesis Strategy.
Chembiochem, 14, 2013
4AHP
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BU of 4ahp by Molmil
Crystal Structure of Wild Type N-acetylneuraminic acid lyase from Staphylococcus aureus
Descriptor: CHLORIDE ION, N-ACETYLNEURAMINATE LYASE
Authors:Timms, N, Polyakova, A, Windle, C.L, Trinh, C.H, Nelson, A, Trinh, A.R, Berry, A.
Deposit date:2012-02-06
Release date:2013-01-23
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural Insights Into the Recovery of Aldolase Activity in N-Acetylneuraminic Acid Lyase by Replacement of the Catalytically Active Lysine with Gamma-Thialysine by Using a Chemical Mutagenesis Strategy.
Chembiochem, 14, 2013
6HNN
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BU of 6hnn by Molmil
Crystal structure of wild-type IdmH, a putative polyketide cyclase from Streptomyces antibioticus
Descriptor: Putative polyketide cyclase IdmH
Authors:Drulyte, I, Obajdin, J, Trinh, C, Hemsworth, G.R, Berry, A.
Deposit date:2018-09-16
Release date:2019-11-06
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure of the putative cyclase IdmH from the indanomycin nonribosomal peptide synthase/polyketide synthase.
Iucrj, 6, 2019
2XFW
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BU of 2xfw by Molmil
Structure of the E192N mutant of E. coli N-acetylneuraminic acid lyase in complex with pyruvate in crystal form III
Descriptor: N-ACETYLNEURAMINIC ACID LYASE, PENTAETHYLENE GLYCOL, PYRUVIC ACID
Authors:Campeotto, I, Murshudov, G.N, Bolt, A.H, Trinh, C.H, Phillips, S.E.V, Nelson, A, Pearson, A.R, Berry, A.
Deposit date:2010-05-28
Release date:2010-09-22
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structural Insights Into Substrate Specificity in Variants of N-Acetylneuraminic Acid Lyase Produced by Directed Evolution.
To be Published
6ELK
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BU of 6elk by Molmil
C.elegans MnSOD-3 mutant - Q142H
Descriptor: GLYCEROL, MANGANESE (II) ION, SULFATE ION, ...
Authors:Hunter, G.J, Trinh, C.H, Hunter, T.
Deposit date:2017-09-29
Release date:2017-12-06
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:A Single Mutation is Sufficient to Modify the Metal Selectivity and Specificity of a Eukaryotic Manganese Superoxide Dismutase to Encompass Iron.
Chemistry, 24, 2018
6SWT
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BU of 6swt by Molmil
Affimer9 co-crystalised with the CH domains of alpha actinin 2.
Descriptor: Affimer 9, Alpha-actinin-2
Authors:Peckham, M, Trinh, C.H, Rogers, B.
Deposit date:2019-09-23
Release date:2020-10-07
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Nanoscale Pattern Extraction from Relative Positions of Sparse 3D Localizations.
Nano Lett., 21, 2021
6HNL
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BU of 6hnl by Molmil
Selenomethionine derivative of IdmH 96-104 loop truncation variant
Descriptor: Putative polyketide cyclase IdmH
Authors:Drulyte, I, Obajdin, J, Trinh, C, Hemsworth, G.R, Berry, A.
Deposit date:2018-09-16
Release date:2019-11-06
Last modified:2019-11-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of the putative cyclase IdmH from the indanomycin nonribosomal peptide synthase/polyketide synthase.
Iucrj, 6, 2019
6HNM
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BU of 6hnm by Molmil
Crystal structure of IdmH 96-104 loop truncation variant
Descriptor: putative polyketide cyclase IdmH
Authors:Drulyte, I, Obajdin, J, Trinh, C, Hemsworth, G.R, Berry, A.
Deposit date:2018-09-16
Release date:2019-11-06
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of the putative cyclase IdmH from the indanomycin nonribosomal peptide synthase/polyketide synthase.
Iucrj, 6, 2019
2Q81
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BU of 2q81 by Molmil
Crystal Structure of the Miz-1 BTB/POZ domain
Descriptor: Miz-1 protein, TETRAETHYLENE GLYCOL
Authors:Stead, M.A, Trinh, C.H, Garnett, J.A, Carr, S.B, Edwards, T.A, Wright, S.C.
Deposit date:2007-06-08
Release date:2007-11-06
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:A Beta-Sheet Interaction Interface Directs the Tetramerisation of the Miz-1 POZ Domain
J.Mol.Biol., 373, 2007
4AMA
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BU of 4ama by Molmil
Crystal Structure of N-acetylneuraminic acid lyase from Staphylococcus aureus with the chemical modification thia-lysine at position 165 in complex with pyruvate
Descriptor: N-ACETYLNEURAMINATE LYASE
Authors:Timms, N, Polyakova, A, Windle, C.L, Trinh, C.H, Nelson, A, Pearson, A.R, Berry, A.
Deposit date:2012-03-08
Release date:2013-01-23
Last modified:2019-07-10
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structural insights into the recovery of aldolase activity in N-acetylneuraminic acid lyase by replacement of the catalytically active lysine with gamma-thialysine by using a chemical mutagenesis strategy.
Chembiochem, 14, 2013
6HSV
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BU of 6hsv by Molmil
Engineered higher-order assembly of Cholera Toxin B subunits via the addition of C-terminal parallel coiled-coiled domains
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, CHLORIDE ION, PHOSPHATE ION, ...
Authors:Pearson, A.R, Turnbull, W.B, Ross, J.F, Trinh, C.H, Webb, M.E.
Deposit date:2018-10-01
Release date:2019-03-20
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Directed Assembly of Homopentameric Cholera Toxin B-Subunit Proteins into Higher-Order Structures Using Coiled-Coil Appendages.
J.Am.Chem.Soc., 141, 2019
6YX2
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BU of 6yx2 by Molmil
Crystal structure of SHANK1 PDZ in complex with a peptide-small molecule hybrid
Descriptor: 4-[[(~{E})-5-oxidanylidenepentanoyldiazenyl]methyl]benzoic acid, PWW-THR-ARG-LEU, SH3 and multiple ankyrin repeat domains protein 1
Authors:Hegedus, Z, Hobor, F, Shoemark, D.K, Celis, S, Lian, L.J, Trinh, C.H, Sessions, R.B, Edwards, T.A, Wilson, A.J.
Deposit date:2020-04-30
Release date:2021-01-20
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.62 Å)
Cite:Identification of beta-strand mediated protein-protein interaction inhibitors using ligand-directed fragment ligation.
Chem Sci, 12, 2021
6HJL
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BU of 6hjl by Molmil
Affimer:BclxL
Descriptor: Affimer ADB13, Bcl-2-like protein 1
Authors:Miles, J.A, Trinh, C.H, Tomlinson, D.C, Wilson, A.J, Edwards, T.A.
Deposit date:2018-09-04
Release date:2020-03-18
Last modified:2024-05-15
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Selective Affimers Recognize BCL-2 Family Proteins Through Non-Canonical Structural Motifs
Biorxiv, 2020
6S0D
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BU of 6s0d by Molmil
H30 MnSOD-3 Mutant II
Descriptor: MANGANESE (II) ION, SULFATE ION, Superoxide dismutase [Mn] 2, ...
Authors:Bonetta, R, Trinh, C.H, Hunter, G.J, Hunter, T.
Deposit date:2019-06-14
Release date:2020-04-22
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.52 Å)
Cite:H30 MnSOD-3 Mutant II
To Be Published
6YX0
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BU of 6yx0 by Molmil
Crystal structure of SHANK1 PDZ in complex with a peptide-small molecule hybrid
Descriptor: 4-[[2-(4-oxidanylidenebutanoyl)hydrazinyl]methyl]benzoic acid, PWQ-THR-ARG-LEU, SH3 and multiple ankyrin repeat domains protein 1
Authors:Hegedus, Z, Hobor, F, Shoemark, D.K, Celis, S, Trinh, C.H, Sessions, R.B, Edwards, T.A, Wilson, A.J.
Deposit date:2020-04-30
Release date:2021-01-20
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.57 Å)
Cite:Identification of beta-strand mediated protein-protein interaction inhibitors using ligand-directed fragment ligation.
Chem Sci, 12, 2021
7NY8
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BU of 7ny8 by Molmil
Affimer K69 - KRAS protein complex
Descriptor: Affimer K69, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Turner, A.L, Trinh, C.H, Haza, K.Z, Rao, A, Martin, H.L, Tiede, C, Edwards, T.A, McPherson, M.J, Tomlinson, D.C.
Deposit date:2021-03-21
Release date:2021-07-07
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:RAS-inhibiting biologics identify and probe druggable pockets including an SII-alpha 3 allosteric site.
Nat Commun, 12, 2021
5A8G
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BU of 5a8g by Molmil
Crystal structure of the wild-type Staphylococcus aureus N- acetylneurminic acid lyase in complex with fluoropyruvate
Descriptor: N-ACETYLNEURAMINATE LYASE
Authors:Stockwell, J, Daniels, A.D, Windle, C.L, Harman, T, Woodhall, T, Trinh, C.H, Lebel, T, Pearson, A.R, Mulholland, K, Berry, A, Nelson, A.
Deposit date:2015-07-15
Release date:2015-11-18
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:Evaluation of Fluoropyruvate as Nucleophile in Reactions Catalysed by N-Acetyl Neuraminic Acid Lyase Variants: Scope, Limitations and Stereoselectivity.
Org.Biomol.Chem., 14, 2016

221051

數據於2024-06-12公開中

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