6STJ

Selective Affimers Recognize BCL-2 Family Proteins Through Non-Canonical Structural Motifs

Summary for 6STJ

• Entry DOI: 10.2210/pdb6stj/pdb
• Descriptor: Induced myeloid leukemia cell differentiation protein Mcl-1, Cystatin domain-containing protein (3 entities in total)
• Functional Keywords: affimer, protein binding
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 8
• Total formula weight: 114926.99

Authors

Hobor, F.,Miles, J.A.,Trinh, C.H.,Taylor, J.,Tiede, C.,Rowell, P.R.,Jackson, B.,Nadat, F.,Kyle, H.F.,Wicky, B.I.M.,Clarke, J.,Tomlinson, D.C.,Wilson, A.J.,Edwards, T.A. (deposition date: 2019-09-10, release date: 2020-09-30, Last modification date: 2024-01-24)

• Primary citation: Miles, J.A.,Hobor, F.,Trinh, C.H.,Taylor, J.,Tiede, C.,Rowell, P.R.,Jackson, B.R.,Nadat, F.A.,Ramsahye, P.,Kyle, H.F.,Wicky, B.I.M.,Clarke, J.,Tomlinson, D.C.,Wilson, A.J.,Edwards, T.A.; Selective Affimers Recognise the BCL-2 Family Proteins BCL-x L and MCL-1 through Noncanonical Structural Motifs*.; Chembiochem, 22:232-240, 2021; PubMed: 32961017; DOI: 10.1002/cbic.202000585

Experimental method

X-RAY DIFFRACTION (2.2 Å)