Isoform-specific inhibition of SUMO-dependent protein-protein interactions

Summary for 5ELJ

DescriptorSUMO-Affirmer-S2D5, Small ubiquitin-related modifier 1 (3 entities in total)
Functional Keywordsubiquitin, sumoylation, signaling protein
Biological sourcesynthetic construct
Cellular locationNucleus membrane P63165
Total number of polymer chains2
Total molecular weight22938.19
Hughes, D.J.,Tiede, C.,Hall, N.,Tang, A.A.S.,Trinh, C.H.,Zajac, K.,Mandal, U.,Howell, G.,Edwards, T.A.,McPherson, M.J.,Tomlinson, D.C.,Whitehouse, A. (deposition date: 2015-11-04, release date: 2016-11-16, Last modification date: 2018-04-18)
Primary citation
Hughes, D.J.,Tiede, C.,Penswick, N.,Tang, A.A.,Trinh, C.H.,Mandal, U.,Zajac, K.Z.,Gaule, T.,Howell, G.,Edwards, T.A.,Duan, J.,Feyfant, E.,McPherson, M.J.,Tomlinson, D.C.,Whitehouse, A.
Generation of specific inhibitors of SUMO-1- and SUMO-2/3-mediated protein-protein interactions using Affimer (Adhiron) technology.
Sci Signal, 10:-, 2017
PubMed: 29138295 (PDB entries with the same primary citation)
DOI: 10.1126/scisignal.aaj2005
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.2400000MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-09-16