5ELJ

Isoform-specific inhibition of SUMO-dependent protein-protein interactions

Summary for 5ELJ

DescriptorSUMO-Affirmer-S2D5, Small ubiquitin-related modifier 1 (3 entities in total)
Functional Keywordsubiquitin, sumoylation, signaling protein
Biological sourcesynthetic construct
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Cellular locationNucleus membrane P63165
Total number of polymer chains2
Total molecular weight22938.19
Authors
Hughes, D.J.,Tiede, C.,Hall, N.,Tang, A.A.S.,Trinh, C.H.,Zajac, K.,Mandal, U.,Howell, G.,Edwards, T.A.,McPherson, M.J.,Tomlinson, D.C.,Whitehouse, A. (deposition date: 2015-11-04, release date: 2016-11-16, Last modification date: 2018-04-18)
Primary citation
Hughes, D.J.,Tiede, C.,Penswick, N.,Tang, A.A.,Trinh, C.H.,Mandal, U.,Zajac, K.Z.,Gaule, T.,Howell, G.,Edwards, T.A.,Duan, J.,Feyfant, E.,McPherson, M.J.,Tomlinson, D.C.,Whitehouse, A.
Generation of specific inhibitors of SUMO-1- and SUMO-2/3-mediated protein-protein interactions using Affimer (Adhiron) technology.
Sci Signal, 10:-, 2017
PubMed: 29138295 (PDB entries with the same primary citation)
DOI: 10.1126/scisignal.aaj2005
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.983 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.2400000MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution