5LKY
X-ray crystal structure of N-acetylneuraminic acid lyase in complex with pyruvate, with the phenylalanine at position 190 replaced with the non-canonical amino acid dihydroxypropylcysteine.
Summary for 5LKY
| Entry DOI | 10.2210/pdb5lky/pdb |
| Descriptor | N-acetylneuraminate lyase, DI(HYDROXYETHYL)ETHER (3 entities in total) |
| Functional Keywords | aldolase, non-canonical amino acid, tim barrel, lyase |
| Biological source | Staphylococcus aureus (strain NCTC 8325) |
| Cellular location | Cytoplasm : Q2G160 |
| Total number of polymer chains | 4 |
| Total formula weight | 136746.41 |
| Authors | Windle, C.L.,Trinh, C.H.,Pearson, A.R.,Nelson, A.S.,Berry, A. (deposition date: 2016-07-25, release date: 2017-03-22, Last modification date: 2024-01-10) |
| Primary citation | Windle, C.L.,Simmons, K.J.,Ault, J.R.,Trinh, C.H.,Nelson, A.,Pearson, A.R.,Berry, A. Extending enzyme molecular recognition with an expanded amino acid alphabet. Proc. Natl. Acad. Sci. U.S.A., 114:2610-2615, 2017 Cited by PubMed: 28196894DOI: 10.1073/pnas.1616816114 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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