8DFI
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8DFG
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8E1Z
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8EZL
| Pfs25 in complex with transmission-reducing antibody AS01-50 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 25 kDa ookinete surface antigen, Transmission-reducing antibody AS01-50, ... | Authors: | Shukla, N, Tang, W.K, Tolia, N.H. | Deposit date: | 2022-11-01 | Release date: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | A human antibody epitope map of the malaria vaccine antigen Pfs25. Npj Vaccines, 8, 2023
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8EZM
| Pfs25 in complex with transmission-reducing antibody AS01-63 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 25 kDa ookinete surface antigen, SULFATE ION, ... | Authors: | Shukla, N, Tang, W.K, Tolia, N.H. | Deposit date: | 2022-11-01 | Release date: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | A human antibody epitope map of the malaria vaccine antigen Pfs25. Npj Vaccines, 8, 2023
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8EZK
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7JUM
| Pfs230 D1 domain in complex with neutralizing antibody LMIV230-01 | Descriptor: | Gametocyte surface protein P230, Neutralizing antibody, LMIV230-01 Single-chain Fv | Authors: | Tolia, N, Tang, W.K. | Deposit date: | 2020-08-20 | Release date: | 2021-03-31 | Last modified: | 2021-04-07 | Method: | X-RAY DIFFRACTION (1.998 Å) | Cite: | A human monoclonal antibody blocks malaria transmission and defines a highly conserved neutralizing epitope on gametes. Nat Commun, 12, 2021
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4F33
| Crystal Structure of therapeutic antibody MORAb-009 | Descriptor: | MORAb-009 FAB heavy chain, MORAb-009 FAB light chain, TETRAETHYLENE GLYCOL | Authors: | Xia, D, Ma, J, Tang, W.K, Esser, L. | Deposit date: | 2012-05-08 | Release date: | 2012-07-11 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.749 Å) | Cite: | Recognition of mesothelin by the therapeutic antibody MORAb-009: structural and mechanistic insights. J.Biol.Chem., 287, 2012
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4F3F
| Crystal Structure of Msln7-64 MORAb-009 FAB complex | Descriptor: | MORAb-009 Fab heavy chain, MORAb-009 Fab light chain, Mesothelin | Authors: | Xia, D, Pastan, I, Ma, J, Tang, W.K, Esser, L. | Deposit date: | 2012-05-09 | Release date: | 2012-07-11 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Recognition of mesothelin by the therapeutic antibody MORAb-009: structural and mechanistic insights. J.Biol.Chem., 287, 2012
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6MCK
| p97 D1D2 with CB5083 bound | Descriptor: | 1-[4-(benzylamino)-7,8-dihydro-5H-pyrano[4,3-d]pyrimidin-2-yl]-2-methyl-1H-indole-4-carboxamide, Transitional endoplasmic reticulum ATPase | Authors: | Xia, D, Tang, W.K. | Deposit date: | 2018-08-31 | Release date: | 2019-01-23 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (3.77 Å) | Cite: | Structural Basis of p97 Inhibition by the Site-Selective Anticancer Compound CB-5083. Mol. Pharmacol., 95, 2019
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7U9J
| Crystal structure of Mesothelin-207 fragment | Descriptor: | GLYCEROL, Isoform 3 of Mesothelin, SULFATE ION | Authors: | Zhan, J, Esser, L, Lin, D, Tang, W.K, Xia, D. | Deposit date: | 2022-03-10 | Release date: | 2023-02-01 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.09 Å) | Cite: | Structures of Cancer Antigen Mesothelin and Its Complexes with Therapeutic Antibodies. Cancer Res Commun, 3, 2023
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7UED
| Crystal structure of full length mesothelin bound with MORAb-009 Fab | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Isoform 4 of Mesothelin, ... | Authors: | Zhan, J, Esser, L, Lin, D, Tang, W.K, Xia, D. | Deposit date: | 2022-03-21 | Release date: | 2023-02-01 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structures of Cancer Antigen Mesothelin and Its Complexes with Therapeutic Antibodies. Cancer Res Commun, 3, 2023
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4KO8
| Structure of p97 N-D1 R155H mutant in complex with ATPgS | Descriptor: | MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Transitional endoplasmic reticulum ATPase | Authors: | Xia, D, Tang, W.K. | Deposit date: | 2013-05-11 | Release date: | 2013-11-13 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.98 Å) | Cite: | Altered Intersubunit Communication Is the Molecular Basis for Functional Defects of Pathogenic p97 Mutants. J.Biol.Chem., 288, 2013
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4KOD
| Structure of p97 N-D1 R155H mutant in complex with ADP | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase | Authors: | Xia, D, Tang, W.K. | Deposit date: | 2013-05-11 | Release date: | 2013-11-13 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.96 Å) | Cite: | Altered Intersubunit Communication Is the Molecular Basis for Functional Defects of Pathogenic p97 Mutants. J.Biol.Chem., 288, 2013
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4KLN
| Structure of p97 N-D1 A232E mutant in complex with ATPgS | Descriptor: | MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Transitional endoplasmic reticulum ATPase | Authors: | Xia, D, Tang, W.K. | Deposit date: | 2013-05-07 | Release date: | 2013-11-13 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.62 Å) | Cite: | Altered Intersubunit Communication Is the Molecular Basis for Functional Defects of Pathogenic p97 Mutants. J.Biol.Chem., 288, 2013
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