8DFG
Crystal structure of potently neutralizing human monoclonal antibody 42D6 Fab in complex with MSP1-19
Summary for 8DFG
Entry DOI | 10.2210/pdb8dfg/pdb |
Descriptor | 42D6 Fab Heavy Chain, 42D6 Fab Light Chain, Merozoite surface protein 1, ... (4 entities in total) |
Functional Keywords | merozoite surface protein 1 (msp1), antigen-antibody complex, plasmodium falciparum, antigenic diversion, structural protein-immune system complex, structural protein/immune system |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 6 |
Total formula weight | 123323.28 |
Authors | Patel, P.N.,Tang, W.K.,Tolia, N.H. (deposition date: 2022-06-22, release date: 2022-10-12, Last modification date: 2023-10-18) |
Primary citation | Patel, P.N.,Dickey, T.H.,Hopp, C.S.,Diouf, A.,Tang, W.K.,Long, C.A.,Miura, K.,Crompton, P.D.,Tolia, N.H. Neutralizing and interfering human antibodies define the structural and mechanistic basis for antigenic diversion. Nat Commun, 13:5888-5888, 2022 Cited by PubMed: 36202833DOI: 10.1038/s41467-022-33336-3 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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