8DFG

Crystal structure of potently neutralizing human monoclonal antibody 42D6 Fab in complex with MSP1-19

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (H, I)	42D6 Fab Heavy Chain	polymer	242	26224.3	2		Homo sapiens (Human)
2	B, D (L, M)	42D6 Fab Light Chain	polymer	217	23677.4	2		Homo sapiens (Human)
3	E, F (B, A)	Merozoite surface protein 1	polymer	105	11759.9	2	UniProt (Q8I0U8) Pfam (PF12946)	Plasmodium falciparum 3D7	Merozoite surface antigens,PMMSA
4	G, H, I, J, K... (H, L, I, M, B...)	water	water		18.0	341	Chemie (HOH)

Sequence modifications

B, A: 1 - 93 (UniProt: Q8I0U8)

PDB	External Database	Details
Glu -2	-	expression tag
Thr -1	-	expression tag
Gly 0	-	expression tag
Ala 3	Ser 1609	engineered mutation
Ala 48	Thr 1654	engineered mutation
Gly 94	-	expression tag
Thr 95	-	expression tag
Lys 96	-	expression tag
His 97	-	expression tag
His 98	-	expression tag
His 99	-	expression tag
His 100	-	expression tag
His 101	-	expression tag
His 102	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	123323.3
All*	Total formula weight	123323.3

*Water molecules are not included.