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PDB: 185 results

5TIZ
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Schistosoma japonicum (Blood Fluke) Sulfotransferase
Descriptor: ADENOSINE-3'-5'-DIPHOSPHATE, Sulfotransferase
Authors:Taylor, A.B, Hart, P.J.
Deposit date:2016-10-03
Release date:2017-05-31
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.87 Å)
Cite:Structural and enzymatic insights into species-specific resistance to schistosome parasite drug therapy.
J. Biol. Chem., 292, 2017
1MFI
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CRYSTAL STRUCTURE OF MACROPHAGE MIGRATION INHIBITORY FACTOR COMPLEXED WITH (E)-2-FLUORO-P-HYDROXYCINNAMATE
Descriptor: 2-FLUORO-3-(4-HYDROXYPHENYL)-2E-PROPENEOATE, PROTEIN (MACROPHAGE MIGRATION INHIBITORY FACTOR)
Authors:Taylor, A.B, Johnson Jr, W.H, Czerwinski, R.M, Whitman, C.P, Hackert, M.L.
Deposit date:1998-08-12
Release date:1999-06-22
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of macrophage migration inhibitory factor complexed with (E)-2-fluoro-p-hydroxycinnamate at 1.8 A resolution: implications for enzymatic catalysis and inhibition.
Biochemistry, 38, 1999
1MFF
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MACROPHAGE MIGRATION INHIBITORY FACTOR Y95F MUTANT
Descriptor: MACROPHAGE MIGRATION INHIBITORY FACTOR
Authors:Taylor, A.B, Stamps, S.L, Wang, S.C, Hackert, M.L, Whitman, C.P.
Deposit date:1998-10-19
Release date:1999-07-12
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (2 Å)
Cite:Mechanism of the phenylpyruvate tautomerase activity of macrophage migration inhibitory factor: properties of the P1G, P1A, Y95F, and N97A mutants.
Biochemistry, 39, 2000
1NWA
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Structure of Mycobacterium tuberculosis Methionine Sulfoxide Reductase A in Complex with Protein-bound Methionine
Descriptor: Peptide methionine sulfoxide reductase msrA
Authors:Taylor, A.B, Benglis Jr, D.M, Dhandayuthapani, S, Hart, P.J, TB Structural Genomics Consortium (TBSGC)
Deposit date:2003-02-05
Release date:2003-07-08
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structure of Mycobacterium tuberculosis Methionine Sulfoxide Reductase A in Complex with Protein-bound Methionine
J.Bacteriol., 185, 2003
6CBY
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BU of 6cby by Molmil
Crystal structure of human SET and MYND Domain Containing protein 2 with MTF9975
Descriptor: N-lysine methyltransferase SMYD2, ZINC ION, [3-(4-amino-6-methyl-1H-imidazo[4,5-c]pyridin-1-yl)-3-methylazetidin-1-yl][1-({1-[(1R)-cyclohept-2-en-1-yl]piperidin-4-yl}methyl)-1H-pyrrol-3-yl]methanone
Authors:ZENG, H, DONG, A, Hutchinson, A, Seitova, A, TATLOCK, J, KUMPF, R, OWEN, A, TAYLOR, A, Casimiro-Garcia, A, Bountra, C, Arrowsmith, C.H, Edwards, A.M, BROWN, P.J, WU, H, Structural Genomics Consortium (SGC)
Deposit date:2018-02-05
Release date:2018-03-14
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Selective, Small-Molecule Co-Factor Binding Site Inhibition of a Su(var)3-9, Enhancer of Zeste, Trithorax Domain Containing Lysine Methyltransferase.
J.Med.Chem., 62, 2019
4N3U
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Candida albicans Superoxide Dismutase 5 (SOD5), Cu(II)
Descriptor: CITRATE ANION, COPPER (II) ION, Potential secreted Cu/Zn superoxide dismutase
Authors:Galaleldeen, A, Taylor, A.B, Waninger-Saroni, J.J, Holloway, S.P, Hart, P.J.
Deposit date:2013-10-07
Release date:2014-04-09
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Candida albicans SOD5 represents the prototype of an unprecedented class of Cu-only superoxide dismutases required for pathogen defense.
Proc.Natl.Acad.Sci.USA, 111, 2014
4MCN
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Human SOD1 C57S Mutant, Metal-free
Descriptor: SULFATE ION, Superoxide dismutase [Cu-Zn]
Authors:Sea, K, Sohn, S.H, Durazo, A, Sheng, Y, Shaw, B, Cao, X, Taylor, A.B, Whitson, L.J, Holloway, S.P, Hart, P.J, Cabelli, D.E, Gralla, E.B, Valentine, J.S.
Deposit date:2013-08-21
Release date:2014-08-27
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Insights into the role of the unusual disulfide bond in copper-zinc superoxide dismutase.
J.Biol.Chem., 290, 2015
7TD9
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G-059 bound to the SMARCA4 (BRG1) Bromodomain
Descriptor: 4-phenyl-5H-pyridazino[4,3-b]indol-3-amine, Isoform 4 of Transcription activator BRG1
Authors:Tang, Y, Poy, F, Taylor, A.M, Cochran, A.G, Bellon, S.F.
Deposit date:2021-12-30
Release date:2022-08-17
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.61 Å)
Cite:GNE-064: A Potent, Selective, and Orally Bioavailable Chemical Probe for the Bromodomains of SMARCA2 and SMARCA4 and the Fifth Bromodomain of PBRM1.
J.Med.Chem., 65, 2022
2VR7
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BU of 2vr7 by Molmil
Crystal Structure of G85R ALS mutant of Human Cu,Zn Superoxide Dismutase (CuZnSOD) at 1.58 A resolution
Descriptor: COPPER (II) ION, SULFATE ION, SUPEROXIDE DISMUTASE [CU-ZN], ...
Authors:Antonyuk, S, Cao, X, Seetharaman, S.V, Whitson, L.J, Taylor, A.B, Holloway, S.P, Strange, R.W, Doucette, P.A, Tiwari, A, Hayward, L.J, Padua, S, Cohlberg, J.A, Selverstone Valentine, J, Hasnain, S.S, Hart, P.J.
Deposit date:2008-03-28
Release date:2008-04-15
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.58 Å)
Cite:Structures of the G85R Variant of Sod1 in Familial Amyotrophic Lateral Sclerosis.
J.Biol.Chem., 283, 2008
2W59
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STRUCTURE OF AN AVIAN IGY-FC 3-4 FRAGMENT
Descriptor: GLYCEROL, IGY FCU3-4, alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Fabiane, S.M, Taylor, A.I, Sutton, B.J, Calvert, R.A.
Deposit date:2008-12-08
Release date:2009-01-13
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:The Crystal Structure of an Avian Igy-Fc Fragment Reveals Conservation with Both Mammalian Igg and Ige.
Biochemistry, 48, 2009
2VR8
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BU of 2vr8 by Molmil
Crystal Structure of G85R ALS mutant of Human Cu,Zn Superoxide Dismutase (CuZnSOD) at 1.36 A resolution
Descriptor: COPPER (II) ION, SULFATE ION, SUPEROXIDE DISMUTASE [CU-ZN], ...
Authors:Antonyuk, S, Cao, X, Seetharaman, S.V, Whitson, L.J, Taylor, A.B, Holloway, S.P, Strange, R.W, Doucette, P.A, Tiwari, A, Hayward, L.J, Padua, S, Cohlberg, J.A, Selverstone Valentine, J, Hasnain, S.S, Hart, P.J.
Deposit date:2008-03-28
Release date:2008-04-08
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.36 Å)
Cite:Structures of the G85R Variant of Sod1 in Familial Amyotrophic Lateral Sclerosis.
J.Biol.Chem., 283, 2008
2VYN
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BU of 2vyn by Molmil
Structure of E.Coli GAPDH Rat Sperm GAPDH heterotetramer
Descriptor: FORMIC ACID, GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Frayne, J, Taylor, A, Hall, L, Hadfield, A.
Deposit date:2008-07-25
Release date:2008-08-05
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of Insoluble Rat Sperm Glyceraldehyde-3-Phosphate Dehydrogenase (Gapdh) Via Heterotetramer Formation with Escherichia Coli Gapdh Reveals Target for Contraceptive Design.
J.Biol.Chem., 284, 2009
2VYV
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BU of 2vyv by Molmil
Structure of E.Coli GAPDH Rat Sperm GAPDH heterotetramer
Descriptor: FORMIC ACID, GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ...
Authors:Frayne, J, Taylor, A, Hall, L, Hadfield, A.
Deposit date:2008-07-29
Release date:2008-08-05
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.38 Å)
Cite:Structure of Insoluble Rat Sperm Glyceraldehyde-3-Phosphate Dehydrogenase (Gapdh) Via Heterotetramer Formation with Escherichia Coli Gapdh Reveals Target for Contraceptive Design.
J.Biol.Chem., 284, 2009
4WYM
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BU of 4wym by Molmil
Structural basis of HIV-1 capsid recognition by CPSF6
Descriptor: Capsid protein p24, ISOFORM 2 OF CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 6
Authors:Battacharya, A, Taylor, A.B, Hart, P.J, Ivanov, D.N.
Deposit date:2014-11-17
Release date:2014-12-17
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural basis of HIV-1 capsid recognition by PF74 and CPSF6.
Proc.Natl.Acad.Sci.USA, 111, 2014
4TLW
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BU of 4tlw by Molmil
CARDS TOXIN, FULL-LENGTH
Descriptor: ADP-ribosylating toxin CARDS
Authors:Becker, A, GALALELDEEN, A, Taylor, A.B, Hart, P.J.
Deposit date:2014-05-30
Release date:2015-04-08
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Structure of CARDS toxin, a unique ADP-ribosylating and vacuolating cytotoxin from Mycoplasma pneumoniae.
Proc.Natl.Acad.Sci.USA, 112, 2015
4RSN
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BU of 4rsn by Molmil
Crystal structure of the E267V mutant of cytochrome P450 BM3
Descriptor: Bifunctional P-450/NADPH-P450 reductase, PROTOPORPHYRIN IX CONTAINING FE
Authors:Zhou, W.H, Zhang, A.L, Zhang, T, Ren, X.K, Yorke, J.A, Taylor, A, Wong, L.-L.
Deposit date:2014-11-09
Release date:2015-12-02
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.701 Å)
Cite:Expanding the drug metabolism function of P450BM3
To be Published
4TKP
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BU of 4tkp by Molmil
Complex of Ubc13 with the RING domain of the TRIM5alpha retroviral restriction factor
Descriptor: SULFATE ION, Tripartite motif-containing protein 5, Ubiquitin-conjugating enzyme E2 N, ...
Authors:Johnson, R, Taylor, A.B, Hart, P.J, Ivanov, D.N.
Deposit date:2014-05-27
Release date:2015-07-22
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.08 Å)
Cite:RING Dimerization Links Higher-Order Assembly of TRIM5 alpha to Synthesis of K63-Linked Polyubiquitin.
Cell Rep, 12, 2015
5KZD
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BU of 5kzd by Molmil
N-acetylneuraminate lyase from methicillin-resistant Staphylococcus aureus with bound sialic acid alditol
Descriptor: (2~{S},4~{S},5~{R},6~{R},7~{S},8~{R})-5-acetamido-2,4,6,7,8,9-hexakis(oxidanyl)nonanoic acid, N-acetylneuraminate lyase
Authors:North, R.A, Watson, A.J.A, Pearce, F.G, Muscroft-Taylor, A.C, Friemann, R, Fairbanks, A.J, Dobson, R.C.J.
Deposit date:2016-07-25
Release date:2017-01-11
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.334 Å)
Cite:Structure and inhibition of N-acetylneuraminate lyase from methicillin-resistant Staphylococcus aureus.
FEBS Lett., 590, 2016
5KZE
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N-acetylneuraminate lyase from methicillin-resistant Staphylococcus aureus
Descriptor: GLYCEROL, N-acetylneuraminate lyase, SULFATE ION
Authors:North, R.A, Watson, A.J.A, Pearce, F.G, Muscroft-Taylor, A.C, Friemann, R, Fairbanks, A.J, Dobson, R.C.J.
Deposit date:2016-07-25
Release date:2017-01-11
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Structure and inhibition of N-acetylneuraminate lyase from methicillin-resistant Staphylococcus aureus.
FEBS Lett., 590, 2016
7TAB
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BU of 7tab by Molmil
G-925 bound to the SMARCA4 (BRG1) Bromodomain
Descriptor: 2-(6-amino-5-phenylpyridazin-3-yl)phenol, Isoform 4 of Transcription activator BRG1
Authors:Tang, Y, Poy, F, Taylor, A.M, Cochran, A.G, Bellon, S.F.
Deposit date:2021-12-20
Release date:2022-08-17
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.16 Å)
Cite:GNE-064: A Potent, Selective, and Orally Bioavailable Chemical Probe for the Bromodomains of SMARCA2 and SMARCA4 and the Fifth Bromodomain of PBRM1.
J.Med.Chem., 65, 2022
6CBX
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BU of 6cbx by Molmil
Crystal structure of human SET and MYND Domain Containing protein 2 with MTF1497
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, N-lysine methyltransferase SMYD2, ...
Authors:ZENG, H, DONG, A, Hutchinson, A, Seitova, A, TATLOCK, J, KUMPF, R, OWEN, A, TAYLOR, A, Casimiro-Garcia, A, Bountra, C, Arrowsmith, C.H, Edwards, A.M, BROWN, P.J, WU, H, Structural Genomics Consortium (SGC)
Deposit date:2018-02-05
Release date:2018-03-14
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Crystal structure of human SET and MYND Domain Containing protein 2 with MTF1497
to be published
5WCG
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BU of 5wcg by Molmil
SET and MYND Domain Containing protein 2
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DIMETHYL SULFOXIDE, N-lysine methyltransferase SMYD2, ...
Authors:Dong, A, Zeng, H, Walker, J.R, Hutch, A, Seitova, A, Tatlock, J, Kumpf, R, Owen, A, Taylor, A, Casimiro-Garcia, A, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Brown, P.J, Wu, H, Structural Genomics Consortium (SGC)
Deposit date:2017-06-30
Release date:2017-08-02
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:The crystal structure of SMYD2 in complex with compound MTF003
to be published
2VR6
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BU of 2vr6 by Molmil
Crystal Structure of G85R ALS mutant of Human Cu,Zn Superoxide Dismutase (CuZnSOD) at 1.3 A resolution
Descriptor: COPPER (II) ION, SULFATE ION, SUPEROXIDE DISMUTASE [CU-ZN], ...
Authors:Antonyuk, S, Cao, X, Seetharaman, S.V, Whitson, L.J, Taylor, A.B, Holloway, S.P, Strange, R.W, Doucette, P.A, Tiwari, A, Hayward, L.J, Padua, S, Cohlberg, J.A, Selverstone Valentine, J, Hasnain, S.S, Hart, P.J.
Deposit date:2008-03-28
Release date:2008-04-15
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Structures of the G85R Variant of Sod1 in Familial Amyotrophic Lateral Sclerosis.
J.Biol.Chem., 283, 2008
2QWQ
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Crystal structure of disulfide-bond-crosslinked complex of bovine hsc70 (1-394aa)R171C and bovine Auxilin (810-910aa)D876C in the AMPPNP hydrolyzed form
Descriptor: ACETIC ACID, ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, ...
Authors:Jiang, J, Maes, E.G, Wang, L, Taylor, A.B, Hinck, A.P, Lafer, E.M, Sousa, R.
Deposit date:2007-08-10
Release date:2007-12-18
Last modified:2021-10-20
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:Structural basis of J cochaperone binding and regulation of Hsp70.
Mol.Cell, 28, 2007
2QWL
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Crystal structure of bovine hsc70 (1-394aa)in the ADP state
Descriptor: ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, Heat shock cognate 71 kDa protein, ...
Authors:Jiang, J, Maes, E.G, Wang, L, Taylor, A.B, Hinck, A.P, Lafer, E.M, Sousa, R.
Deposit date:2007-08-10
Release date:2007-12-18
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structural basis of J cochaperone binding and regulation of Hsp70.
Mol.Cell, 28, 2007

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