5DKH

Crystal structure of the bromodomain of human BRM (SMARCA2) in complex with a hydroxyphenyl propenone inhibitor 17

Summary for 5DKH

• Entry DOI: 10.2210/pdb5dkh/pdb
• Descriptor: Probable global transcription activator SNF2L2, ZINC ION, (2E)-3-[(6S,9R)-4-(cyclopropylamino)-6,7,8,9-tetrahydro-5H-6,9-epiminocyclohepta[d]pyrimidin-10-yl]-1-(2-hydroxyphenyl)prop-2-en-1-one, ... (5 entities in total)
• Functional Keywords: swi-snf complex, chromatin remodeling, brg associated factors (baf), transcription
• Biological source: Homo sapiens (Human)
• Cellular location: Nucleus: P51531
• Total number of polymer chains: 3
• Total formula weight: 44383.07

Authors

Tallant, C.,Owen, D.R.,Taylor, A.,Fedorov, O.,Savitsky, P.,Siejka, P.,Srikannathasan, V.,Nowak, R.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Knapp, S. (deposition date: 2015-09-03, release date: 2016-09-14, Last modification date: 2024-01-10)

• Primary citation: Tallant, C.,Owen, D.R.,Taylor, A.,Fedorov, O.,Savitsky, P.,Siejka, P.,Srikannathasan, V.,Nowak, R.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Knapp, S.; Crystal structure of the bromodomain of human BRM (SMARCA2) in complex with a hydroxyphenyl propenone inhibitor 17; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.7 Å)