5DKH

Crystal structure of the bromodomain of human BRM (SMARCA2) in complex with a hydroxyphenyl propenone inhibitor 17

Summary for 5DKH

DescriptorProbable global transcription activator SNF2L2, ZINC ION, (2E)-3-[(6S,9R)-4-(cyclopropylamino)-6,7,8,9-tetrahydro-5H-6,9-epiminocyclohepta[d]pyrimidin-10-yl]-1-(2-hydroxyphenyl)prop-2-en-1-one, ... (5 entities in total)
Functional Keywordsswi-snf complex, chromatin remodeling, brg associated factors (baf), transcription
Biological sourceHomo sapiens (Human)
Cellular locationNucleus P51531
Total number of polymer chains3
Total molecular weight44383.07
Authors
Primary citation
Tallant, C.,Owen, D.R.,Taylor, A.,Fedorov, O.,Savitsky, P.,Siejka, P.,Srikannathasan, V.,Nowak, R.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Knapp, S.
Crystal structure of the bromodomain of human BRM (SMARCA2) in complex with a hydroxyphenyl propenone inhibitor 17
To Be Published,
Experimental method
X-RAY DIFFRACTION (1.7 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.249200.9%6.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution