2W59

STRUCTURE OF AN AVIAN IGY-FC 3-4 FRAGMENT

Summary for 2W59

• Entry DOI: 10.2210/pdb2w59/pdb
• Descriptor: IGY FCU3-4, alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ... (4 entities in total)
• Functional Keywords: immunoglobulin, avian, igy fc, immune system
• Biological source: GALLUS GALLUS (CHICKEN)
• Total number of polymer chains: 2
• Total formula weight: 52711.34

Authors

Fabiane, S.M.,Taylor, A.I.,Sutton, B.J.,Calvert, R.A. (deposition date: 2008-12-08, release date: 2009-01-13, Last modification date: 2024-10-16)

Primary citation

Taylor, A.I.,Fabiane, S.M.,Sutton, B.J.,Calvert, R.A.
The Crystal Structure of an Avian Igy-Fc Fragment Reveals Conservation with Both Mammalian Igg and Ige.
Biochemistry, 48:558-, 2009

PubMed Abstract: Avian IgY is closely related to an ancestor of both mammalian IgG and IgE and thus provides insights into the evolution of antibody structure and function. A recombinant fragment of IgY-Fc consisting of a dimer of the Cupsilon3 and Cupsilon4 domains, Fcupsilon3-4, was expressed and crystallized and its X-ray structure determined to 1.75 A resolution. Fcupsilon3-4 is the only nonmammalian Fc fragment structure determined to date and provides the first structural evidence for an ancient origin of antibody architecture. The Fcupsilon3-4 structure reveals features common to both IgE-Fc and IgG-Fc, and the implications for IgY binding to its receptor are discussed.

PubMed: 19115948
DOI: 10.1021/BI8019993

Experimental method

X-RAY DIFFRACTION (1.75 Å)