1S1Q
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![BU of 1s1q by Molmil](/molmil-images/mine/1s1q) | TSG101(UEV) domain in complex with Ubiquitin | Descriptor: | ACETIC ACID, COPPER (II) ION, SULFATE ION, ... | Authors: | Sundquist, W.I, Schubert, H.L, Kelly, B.N, Hill, G.C, Holton, J.M, Hill, C.P. | Deposit date: | 2004-01-07 | Release date: | 2004-05-04 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Ubiquitin recognition by the human TSG101 protein Mol.Cell, 13, 2004
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7S7J
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![BU of 7s7j by Molmil](/molmil-images/mine/7s7j) | Structure of Human SPASTIN-IST1 complex. | Descriptor: | CALCIUM ION, CHLORIDE ION, IST1 homolog, ... | Authors: | Skalicky, J.J, Sundquist, W.I. | Deposit date: | 2021-09-16 | Release date: | 2022-09-28 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.15 Å) | Cite: | Comprehensive analysis of the human ESCRT-III-MIT domain interactome reveals new cofactors for cytokinetic abscission. Elife, 11, 2022
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5UIE
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![BU of 5uie by Molmil](/molmil-images/mine/5uie) | Vps4-Vta1 complex | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, DOA4-independent degradation protein 4, ... | Authors: | Monroe, N, Shen, P, Han, H, Sundquist, W.I, Hill, C.P. | Deposit date: | 2017-01-13 | Release date: | 2017-04-12 | Last modified: | 2020-01-01 | Method: | ELECTRON MICROSCOPY (5.7 Å) | Cite: | Structural basis of protein translocation by the Vps4-Vta1 AAA ATPase. Elife, 6, 2017
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3ZXP
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![BU of 3zxp by Molmil](/molmil-images/mine/3zxp) | |
5WA1
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![BU of 5wa1 by Molmil](/molmil-images/mine/5wa1) | CHMP4C A232T in complex with ALIX BRO1 | Descriptor: | Charged multivesicular body protein 4c, Programmed cell death 6-interacting protein | Authors: | Wenzel, D.M, Alam, S.L, Sundquist, W.I. | Deposit date: | 2017-06-24 | Release date: | 2018-09-19 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.868 Å) | Cite: | A cancer-associated polymorphism in ESCRT-III disrupts the abscission checkpoint and promotes genome instability. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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5V3R
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![BU of 5v3r by Molmil](/molmil-images/mine/5v3r) | CHMP4C in complex with ALIX BRO1 | Descriptor: | Charged multivesicular body protein 4c, Programmed cell death 6-interacting protein | Authors: | Wenzel, D.M, Alam, S.L, Sundquist, W.I. | Deposit date: | 2017-03-08 | Release date: | 2018-09-12 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.906 Å) | Cite: | A cancer-associated polymorphism in ESCRT-III disrupts the abscission checkpoint and promotes genome instability. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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3C3R
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![BU of 3c3r by Molmil](/molmil-images/mine/3c3r) | ALIX BRO1 CHMP4C complex | Descriptor: | Charged multivesicular body protein 4c peptide, GLYCEROL, Programmed cell death 6-interacting protein | Authors: | McCullough, J.B, Fisher, R.D, Whitby, F.G, Sundquist, W.I, Hill, C.P. | Deposit date: | 2008-01-28 | Release date: | 2008-06-10 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.02 Å) | Cite: | ALIX-CHMP4 interactions in the human ESCRT pathway. Proc.Natl.Acad.Sci.Usa, 105, 2008
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3C3O
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![BU of 3c3o by Molmil](/molmil-images/mine/3c3o) | ALIX Bro1-domain:CHMIP4A co-crystal structure | Descriptor: | Charged multivesicular body protein 4a peptide, GLYCEROL, Programmed cell death 6-interacting protein | Authors: | McCullough, J.B, Fisher, R.D, Whitby, F.G, Sundquist, W.I, Hill, C.P. | Deposit date: | 2008-01-28 | Release date: | 2008-06-10 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | ALIX-CHMP4 interactions in the human ESCRT pathway. Proc.Natl.Acad.Sci.Usa, 105, 2008
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4WZX
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![BU of 4wzx by Molmil](/molmil-images/mine/4wzx) | ULK3 regulates cytokinetic abscission by phosphorylating ESCRT-III proteins | Descriptor: | COBALT (II) ION, IST1 homolog, SULFATE ION, ... | Authors: | Caballe, A, Wenzel, D.M, Agromayor, M, Alam, S.L, Skalicky, J.J, Kloc, M, Carlton, J.G, Labrador, L, Sundquist, W.I, Martin-Serrano, J. | Deposit date: | 2014-11-20 | Release date: | 2015-06-03 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.3859 Å) | Cite: | ULK3 regulates cytokinetic abscission by phosphorylating ESCRT-III proteins. Elife, 4, 2015
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6AP1
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![BU of 6ap1 by Molmil](/molmil-images/mine/6ap1) | Vps4p-Vta1p complex with peptide binding to the central pore of Vps4p | Descriptor: | ACE-ASP-GLU-ILE-VAL-ASN-LYS-VAL-LEU-NH2, ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, ... | Authors: | Han, H, Monroe, N, Shen, P, Sundquist, W.I, Hill, C.P. | Deposit date: | 2017-08-16 | Release date: | 2017-12-06 | Last modified: | 2018-07-18 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | The AAA ATPase Vps4 binds ESCRT-III substrates through a repeating array of dipeptide-binding pockets. Elife, 6, 2017
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6BMF
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![BU of 6bmf by Molmil](/molmil-images/mine/6bmf) | Vps4p-Vta1p complex with peptide binding to the central pore of Vps4p | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, MAGNESIUM ION, ... | Authors: | Han, H, Monroe, N, Shen, P, Sundquist, W.I, Hill, C.P. | Deposit date: | 2017-11-14 | Release date: | 2017-12-06 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | The AAA ATPase Vps4 binds ESCRT-III substrates through a repeating array of dipeptide-binding pockets. Elife, 6, 2017
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5KP9
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![BU of 5kp9 by Molmil](/molmil-images/mine/5kp9) | Structure of Nanoparticle Released from Enveloped Protein Nanoparticle | Descriptor: | EPN-01* | Authors: | Votteler, J, Ogohara, C, Yi, S, Hsia, Y, Natterman, U, Belnap, D.M, King, N.P, Sundquist, W.I. | Deposit date: | 2016-07-02 | Release date: | 2016-12-07 | Last modified: | 2019-12-11 | Method: | ELECTRON MICROSCOPY (5.7 Å) | Cite: | Designed proteins induce the formation of nanocage-containing extracellular vesicles. Nature, 540, 2016
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1XWI
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![BU of 1xwi by Molmil](/molmil-images/mine/1xwi) | |
1YXR
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![BU of 1yxr by Molmil](/molmil-images/mine/1yxr) | NMR Structure of VPS4A MIT Domain | Descriptor: | vacuolar protein sorting factor 4A | Authors: | Scott, J.A, Gaspar, J, Stuchell, M, Alam, S, Skalicky, J, Sundquist, W.I. | Deposit date: | 2005-02-22 | Release date: | 2005-09-06 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | NMR Structure of VPS4A MIT Domain To be Published
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6NDY
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![BU of 6ndy by Molmil](/molmil-images/mine/6ndy) | Vps4 with Cyclic Peptide Bound in the Central Pore | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, Designed Cyclic Peptide, ... | Authors: | Han, H, Fulcher, J.M, Dandey, V.P, Sundquist, W.I, Kay, M.S, Shen, P, Hill, C.P. | Deposit date: | 2018-12-14 | Release date: | 2019-08-21 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structure of Vps4 with circular peptides and implications for translocation of two polypeptide chains by AAA+ ATPases. Elife, 8, 2019
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1Q5W
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![BU of 1q5w by Molmil](/molmil-images/mine/1q5w) | Ubiquitin Recognition by Npl4 Zinc-Fingers | Descriptor: | Ubiquitin, ZINC ION, homolog of yeast nuclear protein localization 4 | Authors: | Alam, S.L, Sun, J, Payne, M, Welch, B.D, Blake, B.K, Davis, D.R, Meyer, H.H, Emr, S.D, Sundquist, W.I. | Deposit date: | 2003-08-11 | Release date: | 2004-03-30 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Ubiquitin interactions of NZF zinc fingers. Embo J., 23, 2004
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6OO2
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![BU of 6oo2 by Molmil](/molmil-images/mine/6oo2) | Vps4 with Cyclic Peptide Bound in the Central Pore | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, Designed Cyclic Peptide, ... | Authors: | Han, H, Fulcher, J.M, Dandey, V.P, Sundquist, W.I, Kay, M.S, Shen, P, Hill, C.P. | Deposit date: | 2019-04-22 | Release date: | 2019-08-21 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (4.4 Å) | Cite: | Structure of Vps4 with circular peptides and implications for translocation of two polypeptide chains by AAA+ ATPases. Elife, 8, 2019
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6PEK
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![BU of 6pek by Molmil](/molmil-images/mine/6pek) | Structure of Spastin Hexamer (Subunit A-E) in complex with substrate peptide | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, MAGNESIUM ION, ... | Authors: | Han, H, Schubert, H.L, McCullough, J, Monroe, N, Sundquist, W.I, Hill, C.P. | Deposit date: | 2019-06-20 | Release date: | 2019-12-04 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Structure of spastin bound to a glutamate-rich peptide implies a hand-over-hand mechanism of substrate translocation. J.Biol.Chem., 295, 2020
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6PEN
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![BU of 6pen by Molmil](/molmil-images/mine/6pen) | Structure of Spastin Hexamer (whole model) in complex with substrate peptide | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, EYEYEYEYEY, ... | Authors: | Han, H, Schubert, H.L, McCullough, J, Monroe, N, Sundquist, W.I, Hill, C.P. | Deposit date: | 2019-06-20 | Release date: | 2019-12-04 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Structure of spastin bound to a glutamate-rich peptide implies a hand-over-hand mechanism of substrate translocation. J.Biol.Chem., 295, 2020
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2XS8
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![BU of 2xs8 by Molmil](/molmil-images/mine/2xs8) | Crystal Structure of ALIX in complex with the SIVagmTan-1 AYDPARKLL Late Domain | Descriptor: | PROGRAMMED CELL DEATH 6-INTERACTING PROTEIN, SIVAGMTAN-1 GAG P6 | Authors: | Zhai, Q, Landesman, M, Robinson, H, Sundquist, W.I, Hill, C.P. | Deposit date: | 2010-09-24 | Release date: | 2010-11-03 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.498 Å) | Cite: | Identification and Structural Characterization of the Alix-Binding Late Domains of Sivmac239 and Sivagmtan-1. J.Virol., 85, 2011
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2XS1
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![BU of 2xs1 by Molmil](/molmil-images/mine/2xs1) | Crystal Structure of ALIX in complex with the SIVmac239 PYKEVTEDL Late Domain | Descriptor: | GAG POLYPROTEIN, PROGRAMMED CELL DEATH 6-INTERACTING PROTEIN | Authors: | Zhai, Q, Landesman, M, Robinson, H, Sundquist, W.I, Hill, C.P. | Deposit date: | 2010-09-24 | Release date: | 2010-11-03 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.296 Å) | Cite: | Identification and Structural Characterization of the Alix-Binding Late Domains of Sivmac239 and Sivagmtan-1. J.Virol., 85, 2011
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3C3Q
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![BU of 3c3q by Molmil](/molmil-images/mine/3c3q) | ALIX Bro1-domain:CHMIP4B co-crystal structure | Descriptor: | Charged multivesicular body protein 4b peptide, GLYCEROL, Programmed cell death 6-interacting protein | Authors: | McCullough, J.B, Fisher, R.D, Whitby, F.G, Sundquist, W.I, Hill, C.P. | Deposit date: | 2008-01-28 | Release date: | 2008-06-10 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | ALIX-CHMP4 interactions in the human ESCRT pathway. Proc.Natl.Acad.Sci.Usa, 105, 2008
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3JC1
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![BU of 3jc1 by Molmil](/molmil-images/mine/3jc1) | Electron cryo-microscopy of the IST1-CHMP1B ESCRT-III copolymer | Descriptor: | Charged multivesicular body protein 1b, Increased Sodium Tolerance 1 (IST1) | Authors: | McCullough, J, Clippinger, A.K, Talledge, N, Skowyra, M.L, Saunders, M.G, Naismith, T.V, Colf, L.A, Afonine, P, Arthur, C, Sundquist, W.I, Hanson, P.I, Frost, A. | Deposit date: | 2015-11-09 | Release date: | 2015-12-16 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Structure and membrane remodeling activity of ESCRT-III helical polymers. Science, 350, 2015
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1NJ3
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![BU of 1nj3 by Molmil](/molmil-images/mine/1nj3) | Structure and Ubiquitin Interactions of the Conserved NZF Domain of Npl4 | Descriptor: | NPL4, ZINC ION | Authors: | Wang, B, Alam, S.L, Meyer, H.H, Payne, M, Stemmler, T.L, Davis, D.R, Sundquist, W.I. | Deposit date: | 2002-12-30 | Release date: | 2003-04-22 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Structure and ubiquitin interactions of the conserved zinc finger domain of Npl4. J.Biol.Chem., 278, 2003
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1M9E
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![BU of 1m9e by Molmil](/molmil-images/mine/1m9e) | X-ray crystal structure of Cyclophilin A/HIV-1 CA N-terminal domain (1-146) M-type H87A Complex. | Descriptor: | Cyclophilin A, HIV-1 Capsid | Authors: | Howard, B.R, Vajdos, F.F, Li, S, Sundquist, W.I, Hill, C.P. | Deposit date: | 2002-07-28 | Release date: | 2003-05-27 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.72 Å) | Cite: | Structural insights into the catalytic mechanism of cyclophilin A Nat.Struct.Biol., 10, 2003
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