6PEK

Structure of Spastin Hexamer (Subunit A-E) in complex with substrate peptide

Summary for 6PEK

Entry DOI	10.2210/pdb6pek/pdb
EMDB information	20327
Descriptor	Spastin, substrate peptide, TYR-GLU-TYR-GLU-TYR-GLU-TYR-GLU, ADENOSINE-5'-DIPHOSPHATE, ... (5 entities in total)
Functional Keywords	aaa+ atpase, microtubule severing, motor protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	6
Total formula weight	276468.35
Authors	Han, H.,Schubert, H.L.,McCullough, J.,Monroe, N.,Sundquist, W.I.,Hill, C.P. (deposition date: 2019-06-20, release date: 2019-12-04, Last modification date: 2024-03-20)
Primary citation	Han, H.,Schubert, H.L.,McCullough, J.,Monroe, N.,Purdy, M.D.,Yeager, M.,Sundquist, W.I.,Hill, C.P. Structure of spastin bound to a glutamate-rich peptide implies a hand-over-hand mechanism of substrate translocation. J.Biol.Chem., 295:435-443, 2020 Cited by PubMed: 31767681 DOI: 10.1074/jbc.AC119.009890 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (4.2 Å)

Structure validation