6PEK
Structure of Spastin Hexamer (Subunit A-E) in complex with substrate peptide
Summary for 6PEK
Entry DOI | 10.2210/pdb6pek/pdb |
EMDB information | 20327 |
Descriptor | Spastin, substrate peptide, TYR-GLU-TYR-GLU-TYR-GLU-TYR-GLU, ADENOSINE-5'-DIPHOSPHATE, ... (5 entities in total) |
Functional Keywords | aaa+ atpase, microtubule severing, motor protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 6 |
Total formula weight | 276468.35 |
Authors | Han, H.,Schubert, H.L.,McCullough, J.,Monroe, N.,Sundquist, W.I.,Hill, C.P. (deposition date: 2019-06-20, release date: 2019-12-04, Last modification date: 2024-03-20) |
Primary citation | Han, H.,Schubert, H.L.,McCullough, J.,Monroe, N.,Purdy, M.D.,Yeager, M.,Sundquist, W.I.,Hill, C.P. Structure of spastin bound to a glutamate-rich peptide implies a hand-over-hand mechanism of substrate translocation. J.Biol.Chem., 295:435-443, 2020 Cited by PubMed: 31767681DOI: 10.1074/jbc.AC119.009890 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (4.2 Å) |
Structure validation
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