4XP8
 
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4S2J
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8EXP
 | | Cryo-EM structure of S. aureus BlaR1 with C2 symmetry | | 分子名称: | Beta-lactam sensor/signal transducer BlaR1, ZINC ION | | 著者 | Worrall, L.J, Alexander, J.A.N, Vuckovic, M, Strynadka, N.C.J. | | 登録日 | 2022-10-25 | | 公開日 | 2023-01-11 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | | 主引用文献 | Structural basis of broad-spectrum beta-lactam resistance in Staphylococcus aureus.
Nature, 613, 2023
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8EXS
 | | Cryo-EM structure of S. aureus BlaR1 F284A mutant | | 分子名称: | Beta-lactam sensor/signal transducer BlaR1, ZINC ION | | 著者 | Alexander, J.A.N, Hu, J, Worrall, L.J, Strynadka, N.C.J. | | 登録日 | 2022-10-25 | | 公開日 | 2023-01-11 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | | 主引用文献 | Structural basis of broad-spectrum beta-lactam resistance in Staphylococcus aureus.
Nature, 613, 2023
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8EXR
 | | Cryo-EM structure of S. aureus BlaR1 TM and zinc metalloprotease domain | | 分子名称: | (2S)-3-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-2-[(6E)-HEXADEC-6-ENOYLOXY]PROPYL (8E)-OCTADEC-8-ENOATE, Beta-lactam sensor/signal transducer BlaR1, PHOSPHATE ION, ... | | 著者 | Worrall, L.J, Alexander, J.A.N, Vuckovic, M, Strynadka, N.C.J. | | 登録日 | 2022-10-25 | | 公開日 | 2023-01-11 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Structural basis of broad-spectrum beta-lactam resistance in Staphylococcus aureus.
Nature, 613, 2023
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8EXT
 | | Cryo-EM structure of S. aureus BlaR1 F284A mutant in complex with ampicillin | | 分子名称: | Beta-lactam sensor/signal transducer BlaR1, ZINC ION | | 著者 | Alexander, J.A.N, Hu, J, Worrall, L.J, Strynadka, N.C.J. | | 登録日 | 2022-10-25 | | 公開日 | 2023-01-11 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (4.6 Å) | | 主引用文献 | Structural basis of broad-spectrum beta-lactam resistance in Staphylococcus aureus.
Nature, 613, 2023
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4S2O
 | | OXA-10 in complex with Avibactam | | 分子名称: | (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide, Beta-lactamase OXA-10, COBALT (II) ION | | 著者 | King, D.T, Strynadka, N.C.J. | | 登録日 | 2015-01-21 | | 公開日 | 2015-02-25 | | 最終更新日 | 2017-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Molecular Mechanism of Avibactam-Mediated beta-Lactamase Inhibition.
ACS Infect Dis, 1, 2015
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8EXQ
 | | Cryo-EM structure of S. aureus BlaR1 with C1 symmetry | | 分子名称: | Beta-lactam sensor/signal transducer BlaR1, ZINC ION | | 著者 | Worrall, L.J, Alexander, J.A.N, Vuckovic, M, Strynadka, N.C.J. | | 登録日 | 2022-10-25 | | 公開日 | 2023-01-11 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (4.9 Å) | | 主引用文献 | Structural basis of broad-spectrum beta-lactam resistance in Staphylococcus aureus.
Nature, 613, 2023
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4S2N
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4S2I
 | | CTX-M-15 in complex with Avibactam | | 分子名称: | (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide, Beta-lactamase | | 著者 | King, D.T, Strynadka, N.C.J. | | 登録日 | 2015-01-20 | | 公開日 | 2015-02-25 | | 最終更新日 | 2017-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Molecular Mechanism of Avibactam-Mediated beta-Lactamase Inhibition.
ACS Infect Dis, 1, 2015
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4S2K
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4S2P
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8FFJ
 | | Structure of Zanidatamab bound to HER2 | | 分子名称: | Receptor tyrosine-protein kinase erbB-2, Zanidatamab Heavy Chain A, Zanidatamab Heavy Chain B, ... | | 著者 | Worrall, L.J, Atkinson, C.E, Sanches, M, Dixit, S, Strynadka, N.C.J. | | 登録日 | 2022-12-08 | | 公開日 | 2023-02-22 | | 最終更新日 | 2024-09-04 | | 実験手法 | ELECTRON MICROSCOPY (7.5 Å) | | 主引用文献 | An anti-HER2 biparatopic antibody that induces unique HER2 clustering and complement-dependent cytotoxicity.
Nat Commun, 14, 2023
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4OYC
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3T07
 | | Crystal structure of S. aureus Pyruvate Kinase in complex with a naturally occurring bis-indole alkaloid | | 分子名称: | (3S,5R)-3,5-bis(6-bromo-1H-indol-3-yl)piperazin-2-one, PHOSPHATE ION, Pyruvate kinase | | 著者 | Worrall, L.J, Vuckovic, M, Strynadka, N.C.J. | | 登録日 | 2011-07-19 | | 公開日 | 2011-10-26 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | | 主引用文献 | Methicillin-resistant Staphylococcus aureus (MRSA) pyruvate kinase as a target for bis-indole alkaloids with antibacterial activities.
J.Biol.Chem., 286, 2011
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3T05
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4Q6V
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4Q6Z
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4Q6L
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1SN8
 | | Crystal structure of the S1 domain of RNase E from E. coli (Pb derivative) | | 分子名称: | LEAD (II) ION, Ribonuclease E | | 著者 | Schubert, M, Edge, R.E, Lario, P, Cook, M.A, Strynadka, N.C.J, Mackie, G.A, McIntosh, L.P. | | 登録日 | 2004-03-10 | | 公開日 | 2004-08-17 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structural characterization of the RNase E S1 domain and identification of its oligonucleotide-binding and dimerization interfaces.
J.Mol.Biol., 341, 2004
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1SMX
 | | Crystal structure of the S1 domain of RNase E from E. coli (native) | | 分子名称: | Ribonuclease E | | 著者 | Schubert, M, Edge, R.E, Lario, P, Cook, M.A, Strynadka, N.C.J, Mackie, G.A, McIntosh, L.P. | | 登録日 | 2004-03-09 | | 公開日 | 2004-08-17 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Structural characterization of the RNase E S1 domain and identification of its oligonucleotide-binding and dimerization interfaces.
J.Mol.Biol., 341, 2004
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6UEX
 | | Crystal structure of S. aureus LcpA in complex with octaprenyl-pyrophosphate-GlcNAc | | 分子名称: | 2-(acetylamino)-2-deoxy-1-O-[(S)-hydroxy{[(S)-hydroxy{[(2Z,6Z,10Z,14Z,18Z,22Z,26Z)-3,7,11,15,19,23,27,31-octamethyldotriaconta-2,6,10,14,18,22,26,30-octaen-1-yl]oxy}phosphoryl]oxy}phosphoryl]-alpha-D-glucopyranose, GLYCEROL, Regulatory protein MsrR, ... | | 著者 | Li, F.K.K, Strynadka, N.C.J. | | 登録日 | 2019-09-23 | | 公開日 | 2020-01-29 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Crystallographic analysis ofStaphylococcus aureusLcpA, the primary wall teichoic acid ligase.
J.Biol.Chem., 295, 2020
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3L7L
 | | Structure of the Wall Teichoic Acid Polymerase TagF, H444N + CDPG (30 minute soak) | | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, SULFATE ION, ... | | 著者 | Lovering, A.L, Strynadka, N.C.J. | | 登録日 | 2009-12-28 | | 公開日 | 2010-04-28 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | | 主引用文献 | Structure of the bacterial teichoic acid polymerase TagF provides insights into membrane association and catalysis.
Nat.Struct.Mol.Biol., 17, 2010
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6UF6
 | | Crystal structure of B. subtilis TagU | | 分子名称: | GLYCEROL, Polyisoprenyl-teichoic acid--peptidoglycan teichoic acid transferase TagU, SULFATE ION | | 著者 | Li, F.K.K, Strynadka, N.C.J. | | 登録日 | 2019-09-23 | | 公開日 | 2020-01-29 | | 最終更新日 | 2020-03-11 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Crystallographic analysis ofStaphylococcus aureusLcpA, the primary wall teichoic acid ligase.
J.Biol.Chem., 295, 2020
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3LCE
 | | Crystal Structure of Oxa-10 Beta-Lactamase Covalently Bound to Cyclobutanone Beta-Lactam Mimic | | 分子名称: | (1S,3S,4S,5S)-7,7-dichloro-3-methoxy-2-thiabicyclo[3.2.0]heptan-6-one-4-carboxylic acid, Beta-lactamase OXA-10, GLYCEROL, ... | | 著者 | Gretes, M, Strynadka, N.C.J. | | 登録日 | 2010-01-10 | | 公開日 | 2010-03-09 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Cyclobutanone Analogues of beta-Lactams Revisited: Insights into Conformational Requirements for Inhibition of Serine- and Metallo-beta-Lactamases.
J.Am.Chem.Soc., 132, 2010
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