3T07
Crystal structure of S. aureus Pyruvate Kinase in complex with a naturally occurring bis-indole alkaloid
Summary for 3T07
| Entry DOI | 10.2210/pdb3t07/pdb |
| Related | 3T05 3T0T |
| Descriptor | Pyruvate kinase, PHOSPHATE ION, (3S,5R)-3,5-bis(6-bromo-1H-indol-3-yl)piperazin-2-one (3 entities in total) |
| Functional Keywords | tetramer, ligand, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
| Biological source | Staphylococcus aureus subsp. aureus |
| Total number of polymer chains | 4 |
| Total formula weight | 263438.99 |
| Authors | Worrall, L.J.,Vuckovic, M.,Strynadka, N.C.J. (deposition date: 2011-07-19, release date: 2011-10-26, Last modification date: 2024-02-28) |
| Primary citation | Zoraghi, R.,Worrall, L.,See, R.H.,Strangman, W.,Popplewell, W.L.,Gong, H.,Samaai, T.,Swayze, R.D.,Kaur, S.,Vuckovic, M.,Finlay, B.B.,Brunham, R.C.,McMaster, W.R.,Davies-Coleman, M.T.,Strynadka, N.C.,Andersen, R.J.,Reiner, N.E. Methicillin-resistant Staphylococcus aureus (MRSA) pyruvate kinase as a target for bis-indole alkaloids with antibacterial activities. J.Biol.Chem., 286:44716-44725, 2011 Cited by PubMed: 22030393DOI: 10.1074/jbc.M111.289033 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (3.3 Å) |
Structure validation
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