3T07

Crystal structure of S. aureus Pyruvate Kinase in complex with a naturally occurring bis-indole alkaloid

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Pyruvate kinase	polymer	606	65520.7	4	UniProt (Q6GG09)	Staphylococcus aureus subsp. aureus	PK
2	E, G, H, J (A, B, C, D)	PHOSPHATE ION	non-polymer		95.0	4	Chemie (PO4)
3	F, I (B, D)	(3S,5R)-3,5-bis(6-bromo-1H-indol-3-yl)piperazin-2-one	non-polymer		488.2	2	Chemie (09C)

Sequence modifications

A, B, C, D: 1 - 585 (UniProt: Q6GG09)

PDB	External Database	Details
Met -20	-	expression tag
Gly -19	-	expression tag
Ser -18	-	expression tag
Ser -17	-	expression tag
His -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
Ser -10	-	expression tag
Ser -9	-	expression tag
Gly -8	-	expression tag
Leu -7	-	expression tag
Val -6	-	expression tag
Pro -5	-	expression tag
Arg -4	-	expression tag
Gly -3	-	expression tag
Ser -2	-	expression tag
His -1	-	expression tag
Met 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	262082.8
Non-Polymers*	Number of molecules	6
	Total formula weight	1356.2
All*	Total formula weight	263439.0

*Water molecules are not included.