8FFJ
Structure of Zanidatamab bound to HER2
Summary for 8FFJ
Entry DOI | 10.2210/pdb8ffj/pdb |
EMDB information | 29044 |
Descriptor | Receptor tyrosine-protein kinase erbB-2, Zanidatamab Heavy Chain A, Zanidatamab Light Chain A, ... (4 entities in total) |
Functional Keywords | antibody, biparatopic, transferase-immune system complex, transferase/immune system |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 4 |
Total formula weight | 194044.89 |
Authors | Worrall, L.J.,Atkinson, C.E.,Sanches, M.,Dixit, S.,Strynadka, N.C.J. (deposition date: 2022-12-08, release date: 2023-02-22, Last modification date: 2024-09-04) |
Primary citation | Weisser, N.E.,Sanches, M.,Escobar-Cabrera, E.,O'Toole, J.,Whalen, E.,Chan, P.W.Y.,Wickman, G.,Abraham, L.,Choi, K.,Harbourne, B.,Samiotakis, A.,Rojas, A.H.,Volkers, G.,Wong, J.,Atkinson, C.E.,Baardsnes, J.,Worrall, L.J.,Browman, D.,Smith, E.E.,Baichoo, P.,Cheng, C.W.,Guedia, J.,Kang, S.,Mukhopadhyay, A.,Newhook, L.,Ohrn, A.,Raghunatha, P.,Zago-Schmitt, M.,Schrag, J.D.,Smith, J.,Zwierzchowski, P.,Scurll, J.M.,Fung, V.,Black, S.,Strynadka, N.C.J.,Gold, M.R.,Presta, L.G.,Ng, G.,Dixit, S. An anti-HER2 biparatopic antibody that induces unique HER2 clustering and complement-dependent cytotoxicity. Nat Commun, 14:1394-1394, 2023 Cited by PubMed: 36914633DOI: 10.1038/s41467-023-37029-3 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (7.5 Å) |
Structure validation
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