3LCE

Crystal Structure of Oxa-10 Beta-Lactamase Covalently Bound to Cyclobutanone Beta-Lactam Mimic

Summary for 3LCE

Entry DOI	10.2210/pdb3lce/pdb
Descriptor	Beta-lactamase OXA-10, GLYCEROL, (1S,3S,4S,5S)-7,7-dichloro-3-methoxy-2-thiabicyclo[3.2.0]heptan-6-one-4-carboxylic acid, ... (5 entities in total)
Functional Keywords	beta-lactamase, beta-lactamase inhibitor, beta-lactam mimic, cyclobutanone, hemiketal, antibiotic resistance, disulfide bond, hydrolase, plasmid, transposable element
Biological source	Pseudomonas aeruginosa
Total number of polymer chains	4
Total formula weight	112014.38
Authors	Gretes, M.,Strynadka, N.C.J. (deposition date: 2010-01-10, release date: 2010-03-09, Last modification date: 2023-11-22)
Primary citation	Johnson, J.W.,Gretes, M.,Goodfellow, V.J.,Marrone, L.,Heynen, M.L.,Strynadka, N.C.,Dmitrienko, G.I. Cyclobutanone Analogues of beta-Lactams Revisited: Insights into Conformational Requirements for Inhibition of Serine- and Metallo-beta-Lactamases. J.Am.Chem.Soc., 132:2558-2560, 2010 Cited by PubMed: 20141132 DOI: 10.1021/ja9086374 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation