8EXR

Cryo-EM structure of S. aureus BlaR1 TM and zinc metalloprotease domain

Summary for 8EXR

Entry DOI	10.2210/pdb8exr/pdb
EMDB information	28658 28659 28660 28661 28662
Descriptor	Beta-lactam sensor/signal transducer BlaR1, ZINC ION, (2S)-3-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-2-[(6E)-HEXADEC-6-ENOYLOXY]PROPYL (8E)-OCTADEC-8-ENOATE, ... (4 entities in total)
Functional Keywords	antibiotic resistance, beta-lactam antibiotics, mrsa, blar1, mecr1, cryo-em, transmembrane signalling, signaling protein
Biological source	Staphylococcus aureus
Total number of polymer chains	3
Total formula weight	215718.82
Authors	Worrall, L.J.,Alexander, J.A.N.,Vuckovic, M.,Strynadka, N.C.J. (deposition date: 2022-10-25, release date: 2023-01-11, Last modification date: 2023-01-25)
Primary citation	Alexander, J.A.N.,Worrall, L.J.,Hu, J.,Vuckovic, M.,Satishkumar, N.,Poon, R.,Sobhanifar, S.,Rosell, F.I.,Jenkins, J.,Chiang, D.,Mosimann, W.A.,Chambers, H.F.,Paetzel, M.,Chatterjee, S.S.,Strynadka, N.C.J. Structural basis of broad-spectrum beta-lactam resistance in Staphylococcus aureus. Nature, 613:375-382, 2023 Cited by PubMed: 36599987 DOI: 10.1038/s41586-022-05583-3 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.8 Å)

Structure validation