8EXT

Cryo-EM structure of S. aureus BlaR1 F284A mutant in complex with ampicillin

Summary for 8EXT

Entry DOI	10.2210/pdb8ext/pdb
EMDB information	28658 28659 28660 28661 28662
Descriptor	Beta-lactam sensor/signal transducer BlaR1, ZINC ION (2 entities in total)
Functional Keywords	antibiotic resistance, beta-lactam antibiotics, mrsa, blar1, mecr1, cryo-em, transmembrane signalling, signaling protein-antibiotic complex, signaling protein/antibiotic
Biological source	Staphylococcus aureus
Total number of polymer chains	2
Total formula weight	142518.02
Authors	Alexander, J.A.N.,Hu, J.,Worrall, L.J.,Strynadka, N.C.J. (deposition date: 2022-10-25, release date: 2023-01-11, Last modification date: 2023-01-25)
Primary citation	Alexander, J.A.N.,Worrall, L.J.,Hu, J.,Vuckovic, M.,Satishkumar, N.,Poon, R.,Sobhanifar, S.,Rosell, F.I.,Jenkins, J.,Chiang, D.,Mosimann, W.A.,Chambers, H.F.,Paetzel, M.,Chatterjee, S.S.,Strynadka, N.C.J. Structural basis of broad-spectrum beta-lactam resistance in Staphylococcus aureus. Nature, 613:375-382, 2023 Cited by PubMed: 36599987 DOI: 10.1038/s41586-022-05583-3 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (4.6 Å)

Structure validation