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PDB: 246 件
2AZB
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BU of 2azb by Molmil
HIV-1 Protease NL4-3 3X mutant in complex with inhibitor, TL-3
分子名称: PROTEASE RETROPEPSIN, benzyl [(1S,4S,7S,8R,9R,10S,13S,16S)-7,10-dibenzyl-8,9-dihydroxy-1,16-dimethyl-4,13-bis(1-methylethyl)-2,5,12,15,18-pentaoxo-20-phenyl-19-oxa-3,6,11,14,17-pentaazaicos-1-yl]carbamate
著者Heaslet, H, Kutilek, V, Morris, G.M, Lin, Y.-C, Elder, J.H, Torbett, B.E, Stout, C.D.
登録日2005-09-09
公開日2006-02-28
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.03 Å)
主引用文献Structural Insights into the Mechanisms of Drug Resistance in HIV-1 Protease NL4-3
J.Mol.Biol., 356, 2006
2AZ8
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BU of 2az8 by Molmil
HIV-1 Protease NL4-3 in complex with inhibitor, TL-3
分子名称: PROTEASE RETROPEPSIN, benzyl [(1S,4S,7S,8R,9R,10S,13S,16S)-7,10-dibenzyl-8,9-dihydroxy-1,16-dimethyl-4,13-bis(1-methylethyl)-2,5,12,15,18-pentaoxo-20-phenyl-19-oxa-3,6,11,14,17-pentaazaicos-1-yl]carbamate
著者Heaslet, H, Kutilek, V, Morris, G.M, Lin, Y.-C, Elder, J.H, Torbett, B.E, Stout, C.D.
登録日2005-09-09
公開日2006-02-28
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural Insights into the Mechanisms of Drug Resistance in HIV-1 Protease NL4-3
J.Mol.Biol., 356, 2006
2AZ9
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BU of 2az9 by Molmil
HIV-1 Protease NL4-3 1X mutant
分子名称: PROTEASE RETROPEPSIN, benzyl [(1S,4S,7S,8R,9R,10S,13S,16S)-7,10-dibenzyl-8,9-dihydroxy-1,16-dimethyl-4,13-bis(1-methylethyl)-2,5,12,15,18-pentaoxo-20-phenyl-19-oxa-3,6,11,14,17-pentaazaicos-1-yl]carbamate
著者Heaslet, H, Kutilek, V, Morris, G.M, Lin, Y.-C, Elder, J.H, Torbett, B.E, Stout, C.D.
登録日2005-09-09
公開日2006-02-28
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural Insights into the Mechanisms of Drug Resistance in HIV-1 Protease NL4-3
J.Mol.Biol., 356, 2006
2FLA
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BU of 2fla by Molmil
Structure of thereduced HiPIP from thermochromatium tepidum at 0.95 angstrom resolution
分子名称: GLYCEROL, High-potential iron-sulfur protein, IRON/SULFUR CLUSTER, ...
著者Hunsicker-Wang, L.M, Stout, C.D, Fee, J.A.
登録日2006-01-05
公開日2006-12-05
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (0.95 Å)
主引用文献Geometric factors determine, in part, the electronic state of the 4Fe-4S cluster of HiPIP: a geometric, crystallographic, and theoretical study.
To be Published
2HAH
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BU of 2hah by Molmil
The structure of FIV 12S protease in complex with TL-3
分子名称: Protease, benzyl [(1S,4S,7S,8R,9R,10S,13S,16S)-7,10-dibenzyl-8,9-dihydroxy-1,16-dimethyl-4,13-bis(1-methylethyl)-2,5,12,15,18-pentaoxo-20-phenyl-19-oxa-3,6,11,14,17-pentaazaicos-1-yl]carbamate
著者Heaslet, H, Lin, Y.C, Elder, J.H, Stout, C.D.
登録日2006-06-12
公開日2007-02-13
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Crystal structure of an FIV/HIV chimeric protease complexed with the broad-based inhibitor, TL-3.
Retrovirology, 4, 2007
2HB4
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BU of 2hb4 by Molmil
Structure of HIV Protease NL4-3 in an Unliganded State
分子名称: MAGNESIUM ION, Protease, R-1,2-PROPANEDIOL
著者Heaslet, H, Tam, K, Elder, J.H, Stout, C.D.
登録日2006-06-13
公開日2007-06-26
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Conformational flexibility in the flap domains of ligand-free HIV protease.
Acta Crystallogr.,Sect.D, 63, 2007
2GOY
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BU of 2goy by Molmil
Crystal structure of assimilatory adenosine 5'-phosphosulfate reductase with bound APS
分子名称: ADENOSINE-5'-PHOSPHOSULFATE, IRON/SULFUR CLUSTER, adenosine phosphosulfate reductase
著者Chartron, J, Carroll, K.S, Shiau, C, Gao, H, Leary, J.A, Bertozzi, C.R, Stout, C.D.
登録日2006-04-14
公開日2006-09-19
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Substrate Recognition, Protein Dynamics, and Iron-Sulfur Cluster in Pseudomonas aeruginosa Adenosine 5'-Phosphosulfate Reductase.
J.Mol.Biol., 364, 2006
2HB2
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BU of 2hb2 by Molmil
Structure of HIV protease 6X mutant in apo form
分子名称: Protease
著者Heaslet, H, Tam, K, Elder, J.H, Stout, C.D.
登録日2006-06-13
公開日2007-06-26
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Conformational flexibility in the flap domains of ligand-free HIV protease.
Acta Crystallogr.,Sect.D, 63, 2007
2HI4
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BU of 2hi4 by Molmil
Crystal Structure of Human Microsomal P450 1A2 in complex with alpha-naphthoflavone
分子名称: 2-PHENYL-4H-BENZO[H]CHROMEN-4-ONE, Cytochrome P450 1A2, PROTOPORPHYRIN IX CONTAINING FE
著者Sansen, S, Yano, J.K, Reynald, R.L, Schoch, G.S, Stout, C.D, Johnson, E.F.
登録日2006-06-29
公開日2007-02-20
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Adaptations for the oxidation of polycyclic aromatic hydrocarbons exhibited by the structure of human P450 1A2.
J.Biol.Chem., 282, 2007
2HC0
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BU of 2hc0 by Molmil
Structure of HIV protease 6X mutant in complex with AB-2.
分子名称: BROMIDE ION, Protease, [1-((1S,2R)-1-BENZYL-2-HYDROXY-3-{ISOBUTYL[(4-METHOXYPHENYL)SULFONYL]AMINO}PROPYL)-1H-1,2,3-TRIAZOL-4-YL]METHYL (1R,2R)-2-HYDROXY-2,3-DIHYDRO-1H-INDEN-1-YLCARBAMATE
著者Heaslet, H, Brik, A, Lin, Y.-C, Elder, J.H, Stout, C.D.
登録日2006-06-14
公開日2007-06-26
最終更新日2021-10-20
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献Structure of HIV Protease 6X Mutant in complex with AB-2
To be Published
3LYN
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BU of 3lyn by Molmil
STRUCTURE OF GREEN ABALONE LYSIN DIMER
分子名称: SPERM LYSIN
著者Kresge, N, Vacquier, V.D, Stout, C.D.
登録日1999-05-19
公開日2000-03-15
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献The high resolution crystal structure of green abalone sperm lysin: implications for species-specific binding of the egg receptor.
J.Mol.Biol., 296, 2000
3OGQ
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BU of 3ogq by Molmil
Crystal Structure of 6s-98S FIV Protease with Lopinavir bound
分子名称: DIMETHYL SULFOXIDE, FIV protease, N-{1-BENZYL-4-[2-(2,6-DIMETHYL-PHENOXY)-ACETYLAMINO]-3-HYDROXY-5-PHENYL-PENTYL}-3-METHYL-2-(2-OXO-TETRAHYDRO-PYRIMIDIN-1-YL)-BUTYRAMIDE
著者Lin, Y.-C, Perryman, A.L, Elder, J.H, Stout, C.D.
登録日2010-08-17
公開日2011-06-08
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structural basis for drug and substrate specificity exhibited by FIV encoding a chimeric FIV/HIV protease.
Acta Crystallogr.,Sect.D, 67, 2011
3OGP
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BU of 3ogp by Molmil
Crystal Structure of 6s-98S FIV Protease with Darunavir bound
分子名称: (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE, DIMETHYL SULFOXIDE, FIV Protease
著者Lin, Y.-C, Perryman, A.L, Elder, J.H, Stout, C.D.
登録日2010-08-17
公開日2011-06-08
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structural basis for drug and substrate specificity exhibited by FIV encoding a chimeric FIV/HIV protease.
Acta Crystallogr.,Sect.D, 67, 2011
2LIS
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BU of 2lis by Molmil
HIGH RESOLUTION STRUCTURE OF THE RED ABALONE LYSIN MONOMER
分子名称: SPERM LYSIN
著者Kresge, N, Vacquier, V.D, Stout, C.D.
登録日1999-04-16
公開日2000-01-21
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.35 Å)
主引用文献1.35 and 2.07 A resolution structures of the red abalone sperm lysin monomer and dimer reveal features involved in receptor binding.
Acta Crystallogr.,Sect.D, 56, 2000
2LYN
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BU of 2lyn by Molmil
HIGH RESOLUTION STRUCTURE OF RED ABALONE LYSIN DIMER
分子名称: SPERM LYSIN
著者Kresge, N, Vacquier, V.D, Stout, C.D.
登録日1999-04-19
公開日2000-01-21
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.07 Å)
主引用文献1.35 and 2.07 A resolution structures of the red abalone sperm lysin monomer and dimer reveal features involved in receptor binding.
Acta Crystallogr.,Sect.D, 56, 2000
1D3W
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BU of 1d3w by Molmil
Crystal structure of ferredoxin 1 d15e mutant from azotobacter vinelandii at 1.7 angstrom resolution.
分子名称: FE3-S4 CLUSTER, FERREDOXIN 1, IRON/SULFUR CLUSTER
著者Chen, K, Hirst, J, Camba, R, Bonagura, C.A, Stout, C.D, Burges, B.K, Armstrong, F.A.
登録日1999-10-01
公開日1999-10-14
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Atomically defined mechanism for proton transfer to a buried redox centre in a protein.
Nature, 405, 2000
1A6L
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BU of 1a6l by Molmil
T14C MUTANT OF AZOTOBACTER VINELANDII FDI
分子名称: FE3-S4 CLUSTER, FERREDOXIN, IRON/SULFUR CLUSTER
著者Gao-Sheridan, H.S, Kemper, M.A, Khayat, R, Armstrong, F.A, Prasad, G.S, Sridhar, V, Stout, C.D, Burgess, B.K.
登録日1998-02-26
公開日1998-05-27
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献A T14C variant of Azotobacter vinelandii ferredoxin I undergoes facile [3Fe-4S]0 to [4Fe-4S]2+ conversion in vitro but not in vivo.
J.Biol.Chem., 273, 1998
2P85
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BU of 2p85 by Molmil
Structure of Human Lung Cytochrome P450 2A13 with indole bound in two alternate conformations
分子名称: Cytochrome P450 2A13, INDOLE, PROTOPORPHYRIN IX CONTAINING FE
著者Scott, E.E, Stout, C.D.
登録日2007-03-21
公開日2007-04-10
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Structure of the human lung cytochrome P450 2A13.
J.Biol.Chem., 282, 2007
2PC0
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BU of 2pc0 by Molmil
Apo Wild-type HIV Protease in the open conformation
分子名称: MAGNESIUM ION, Protease, R-1,2-PROPANEDIOL
著者Heaslet, H, Rosenfeld, R, Giffin, M.J, Elder, J.H, McRee, D.E, Stout, C.D.
登録日2007-03-29
公開日2007-06-26
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Conformational flexibility in the flap domains of ligand-free HIV protease.
Acta Crystallogr.,Sect.D, 63, 2007
2PG5
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BU of 2pg5 by Molmil
Crystal Structure of Human Microsomal P450 2A6 N297Q
分子名称: 1,2-ETHANEDIOL, Cytochrome P450 2A6, PROTOPORPHYRIN IX CONTAINING FE
著者Sansen, S, Hsu, M.H, Stout, C.D, Johnson, E.F.
登録日2007-04-06
公開日2007-07-24
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Structural insight into the altered substrate specificity of human cytochrome P450 2A6 mutants.
Arch.Biochem.Biophys., 464, 2007
2PG7
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Crystal Structure of Human Microsomal P450 2A6 N297Q/I300V
分子名称: Cytochrome P450 2A6, PROTOPORPHYRIN IX CONTAINING FE
著者Sansen, S, Hsu, M.H, Stout, C.D, Johnson, E.F.
登録日2007-04-06
公開日2007-07-24
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structural insight into the altered substrate specificity of human cytochrome P450 2A6 mutants.
Arch.Biochem.Biophys., 464, 2007
2PG6
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Crystal Structure of Human Microsomal P450 2A6 L240C/N297Q
分子名称: Cytochrome P450 2A6, PROTOPORPHYRIN IX CONTAINING FE
著者Sansen, S, Hsu, M.H, Stout, C.D, Johnson, E.F.
登録日2007-04-06
公開日2007-07-24
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.53 Å)
主引用文献Structural insight into the altered substrate specificity of human cytochrome P450 2A6 mutants.
Arch.Biochem.Biophys., 464, 2007
2O8V
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BU of 2o8v by Molmil
PAPS reductase in a covalent complex with thioredoxin C35A
分子名称: Phosphoadenosine phosphosulfate reductase, Thioredoxin 1
著者Chartron, J, Shiau, C, Stout, C.D, Carroll, K.S.
登録日2006-12-12
公開日2007-03-27
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献3'-Phosphoadenosine-5'-phosphosulfate Reductase in Complex with Thioredoxin: A Structural Snapshot in the Catalytic Cycle.
Biochemistry, 46, 2007
2Q6N
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BU of 2q6n by Molmil
Structure of Cytochrome P450 2B4 with Bound 1-(4-cholorophenyl)imidazole
分子名称: 1-(4-CHLOROPHENYL)-1H-IMIDAZOLE, Cytochrome P450 2B4, PROTOPORPHYRIN IX CONTAINING FE
著者Zhao, Y, Sun, L, Muralidhara, B.K, Kumar, S, White, M.A, Stout, C.D, Halpert, J.R.
登録日2007-06-05
公開日2007-11-06
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Structural and thermodynamic consequences of 1-(4-chlorophenyl)imidazole binding to cytochrome P450 2B4.
Biochemistry, 46, 2007
2NNJ
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BU of 2nnj by Molmil
CYP2C8dH complexed with felodipine
分子名称: Cytochrome P450 2C8, FELODIPINE, PALMITIC ACID, ...
著者Schoch, G.A, Yano, J.K, Stout, C.D, Johnson, E.F.
登録日2006-10-24
公開日2007-10-23
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.28 Å)
主引用文献Determinants of cytochrome P450 2C8 substrate binding: structures of complexes with montelukast, troglitazone, felodipine, and 9-cis-retinoic acid.
J.Biol.Chem., 283, 2008

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