2AZ9

HIV-1 Protease NL4-3 1X mutant

Summary for 2AZ9

Entry DOI	10.2210/pdb2az9/pdb
Related	2AZ8 2AZB 2AZC
Related PRD ID	PRD_000434
Descriptor	PROTEASE RETROPEPSIN, benzyl [(1S,4S,7S,8R,9R,10S,13S,16S)-7,10-dibenzyl-8,9-dihydroxy-1,16-dimethyl-4,13-bis(1-methylethyl)-2,5,12,15,18-pentaoxo-20-phenyl-19-oxa-3,6,11,14,17-pentaazaicos-1-yl]carbamate (3 entities in total)
Functional Keywords	hiv, protease, inhibitor, tl-3, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Human immunodeficiency virus 1
Cellular location	Gag-Pol polyprotein: Host cell membrane ; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03367
Total number of polymer chains	1
Total formula weight	11712.86
Authors	Heaslet, H.,Kutilek, V.,Morris, G.M.,Lin, Y.-C.,Elder, J.H.,Torbett, B.E.,Stout, C.D. (deposition date: 2005-09-09, release date: 2006-02-28, Last modification date: 2023-08-23)
Primary citation	Heaslet, H.,Kutilek, V.,Morris, G.M.,Lin, Y.-C.,Elder, J.H.,Torbett, B.E.,Stout, C.D. Structural Insights into the Mechanisms of Drug Resistance in HIV-1 Protease NL4-3 J.Mol.Biol., 356:967-981, 2006 Cited by PubMed: 16403521 DOI: 10.1016/j.jmb.2005.11.094 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation