2AZB
HIV-1 Protease NL4-3 3X mutant in complex with inhibitor, TL-3
Summary for 2AZB
Entry DOI | 10.2210/pdb2azb/pdb |
Related | 2AZ8 2AZ9 2AZC |
Related PRD ID | PRD_000434 |
Descriptor | PROTEASE RETROPEPSIN, benzyl [(1S,4S,7S,8R,9R,10S,13S,16S)-7,10-dibenzyl-8,9-dihydroxy-1,16-dimethyl-4,13-bis(1-methylethyl)-2,5,12,15,18-pentaoxo-20-phenyl-19-oxa-3,6,11,14,17-pentaazaicos-1-yl]carbamate (3 entities in total) |
Functional Keywords | hiv-1, protease, inhibitor, tl-3, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Human immunodeficiency virus 1 |
Cellular location | Gag-Pol polyprotein: Host cell membrane ; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03367 |
Total number of polymer chains | 1 |
Total formula weight | 11660.80 |
Authors | Heaslet, H.,Kutilek, V.,Morris, G.M.,Lin, Y.-C.,Elder, J.H.,Torbett, B.E.,Stout, C.D. (deposition date: 2005-09-09, release date: 2006-02-28, Last modification date: 2023-08-23) |
Primary citation | Heaslet, H.,Kutilek, V.,Morris, G.M.,Lin, Y.-C.,Elder, J.H.,Torbett, B.E.,Stout, C.D. Structural Insights into the Mechanisms of Drug Resistance in HIV-1 Protease NL4-3 J.Mol.Biol., 356:967-981, 2006 Cited by PubMed: 16403521DOI: 10.1016/j.jmb.2005.11.094 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.03 Å) |
Structure validation
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