2PG7

Crystal Structure of Human Microsomal P450 2A6 N297Q/I300V

Summary for 2PG7

Entry DOI	10.2210/pdb2pg7/pdb
Related	1Z10 1Z11 2FDU 2FDV 2FDW 2FDY 2PG5 2PG6
Descriptor	Cytochrome P450 2A6, PROTOPORPHYRIN IX CONTAINING FE (3 entities in total)
Functional Keywords	cyp2a6, p450 2a6, p450, monooxygenases, drug metabolizing enzyme, heme, indole, mutant, oxidoreductase
Biological source	Homo sapiens (human)
Cellular location	Endoplasmic reticulum membrane; Peripheral membrane protein: P11509
Total number of polymer chains	4
Total formula weight	221152.50
Authors	Sansen, S.,Hsu, M.H.,Stout, C.D.,Johnson, E.F. (deposition date: 2007-04-06, release date: 2007-07-24, Last modification date: 2023-08-30)
Primary citation	Sansen, S.,Hsu, M.H.,Stout, C.D.,Johnson, E.F. Structural insight into the altered substrate specificity of human cytochrome P450 2A6 mutants. Arch.Biochem.Biophys., 464:197-206, 2007 Cited by PubMed: 17540336 DOI: 10.1016/j.abb.2007.04.028 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation