1Z11
Crystal Structure of Human Microsomal P450 2A6 with Methoxsalen Bound
Summary for 1Z11
Entry DOI | 10.2210/pdb1z11/pdb |
Related | 1PQ2 1R9O 1TQN 1Z10 |
Descriptor | cytochrome P450, family 2, subfamily A, polypeptide 6, PROTOPORPHYRIN IX CONTAINING FE, METHOXSALEN, ... (4 entities in total) |
Functional Keywords | cyp2a6, p450 2a6, p450, monooxygenase, drug metabolizing enzyme, coumarin 7-hydroxylase, nicotine oxidase, oxidoreductase, heme, methoxsalen |
Biological source | Homo sapiens (human) |
Cellular location | Endoplasmic reticulum membrane; Peripheral membrane protein: P11509 |
Total number of polymer chains | 4 |
Total formula weight | 222017.26 |
Authors | Yano, J.K.,Hsu, M.H.,Griffin, K.J.,Stout, C.D.,Johnson, E.F. (deposition date: 2005-03-02, release date: 2005-08-16, Last modification date: 2023-08-23) |
Primary citation | Yano, J.K.,Hsu, M.H.,Griffin, K.J.,Stout, C.D.,Johnson, E.F. Structures of human microsomal cytochrome P450 2A6 complexed with coumarin and methoxsalen Nat.Struct.Mol.Biol., 12:822-823, 2005 Cited by PubMed: 16086027DOI: 10.1038/nsmb971 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.05 Å) |
Structure validation
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