1Z10

Crystal Structure of Human Microsomal P450 2A6 with Coumarin Bound

Summary for 1Z10

Entry DOI	10.2210/pdb1z10/pdb
Related	1PQ2 1R9O 1TQN 1Z11
Descriptor	cytochrome P450, family 2, subfamily A, polypeptide 6, PROTOPORPHYRIN IX CONTAINING FE, COUMARIN, ... (5 entities in total)
Functional Keywords	cyp2a6, p450 2a6, p450, monooxygenase, drug metabolizing enzyme, coumarin 7-hydroxylase, nicotine oxidase, oxidoreductase, heme
Biological source	Homo sapiens (human)
Cellular location	Endoplasmic reticulum membrane; Peripheral membrane protein: P11509
Total number of polymer chains	4
Total formula weight	221829.16
Authors	Yano, J.K.,Hsu, M.H.,Griffin, K.J.,Stout, C.D.,Johnson, E.F. (deposition date: 2005-03-02, release date: 2005-08-16, Last modification date: 2023-08-23)
Primary citation	Yano, J.K.,Hsu, M.H.,Griffin, K.J.,Stout, C.D.,Johnson, E.F. Structures of human microsomal cytochrome P450 2A6 complexed with coumarin and methoxsalen Nat.Struct.Mol.Biol., 12:822-823, 2005 Cited by PubMed: 16086027 DOI: 10.1038/nsmb971 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation