1Z11

Crystal Structure of Human Microsomal P450 2A6 with Methoxsalen Bound

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	cytochrome P450, family 2, subfamily A, polypeptide 6	polymer	476	54671.6	4	UniProt (P11509) Pfam (PF00067) In PDB	Homo sapiens (human)
2	A, B, C, D	PROTOPORPHYRIN IX CONTAINING FE	non-polymer		616.5	4	Chemie (HEM)
3	A, B, C, D	METHOXSALEN	non-polymer		216.2	4	Chemie (8MO)
4		water	water		18.0	504	Chemie (HOH)

Sequence modifications

A, B, C, D: 29 - 494 (UniProt: P11509)

PDB	External Database	Details
Met 23	-	SEE REMARK 999
Ala 24	-	SEE REMARK 999
Lys 25	-	SEE REMARK 999
Lys 26	-	SEE REMARK 999
Thr 27	-	SEE REMARK 999
Ser 28	-	SEE REMARK 999
His 495	-	expression tag
His 496	-	expression tag
His 497	-	expression tag
His 498	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	218686.5
Non-Polymers*	Number of molecules	8
	Total formula weight	3330.7
All*	Total formula weight	222017.3

*Water molecules are not included.