2FDV

Microsomal P450 2A6 with the inhibitor N-Methyl(5-(pyridin-3-yl)furan-2-yl)methanamine bound

Summary for 2FDV

Entry DOI	10.2210/pdb2fdv/pdb
Related	1Z10 1Z11 2FDU 2FDW 2FDY
Descriptor	Cytochrome P450 2A6, SULFATE ION, PROTOPORPHYRIN IX CONTAINING FE, ... (6 entities in total)
Functional Keywords	cyp2a6, p450 2a6, p450, monooxygenase, drug metabolizing enzyme, coumarin 7-hydroxylase, nicotine oxidase, oxidoreductase
Biological source	Homo sapiens (human)
Cellular location	Endoplasmic reticulum membrane; Peripheral membrane protein: P11509
Total number of polymer chains	4
Total formula weight	222820.19
Authors	Yano, J.K.,Stout, C.D.,Johnson, E.F. (deposition date: 2005-12-14, release date: 2006-11-28, Last modification date: 2023-08-30)
Primary citation	Yano, J.K.,Denton, T.T.,Cerny, M.A.,Zhang, X.,Johnson, E.F.,Cashman, J.R. Synthetic Inhibitors of Cytochrome P-450 2A6: Inhibitory Activity, Difference Spectra, Mechanism of Inhibition, and Protein Cocrystallization. J.Med.Chem., 49:6987-7001, 2006 Cited by PubMed: 17125252 DOI: 10.1021/jm060519r PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.65 Å)

Structure validation