2FDV
Microsomal P450 2A6 with the inhibitor N-Methyl(5-(pyridin-3-yl)furan-2-yl)methanamine bound
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Cytochrome P450 2A6 | polymer | 476 | 54671.6 | 4 | UniProt (P11509) Pfam (PF00067) | Homo sapiens (human) | CYPIIA6, Coumarin 7-hydroxylase, P450 IIA3, CYP2A3, P450I |
| 2 | E, F, G, K, N (A, B, C) | SULFATE ION | non-polymer | 96.1 | 5 | Chemie (SO4) | |||
| 3 | H, L, O, V (A, B, C, D) | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 4 | Chemie (HEM) | |||
| 4 | I, M, P, W (A, B, C, D) | N-METHYL(5-(PYRIDIN-3-YL)FURAN-2-YL)METHANAMINE | non-polymer | 188.2 | 4 | Chemie (D2G) | |||
| 5 | J, Q, R, S, T... (A, C, D) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 7 | Chemie (EDO) | |||
| 6 | AA, BA, Y, Z (C, D, A, B) | water | water | 18.0 | 1437 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 29 - 494 (UniProt: P11509)
| PDB | External Database | Details |
|---|---|---|
| Met 23 | - | cloning artifact |
| Ala 24 | - | cloning artifact |
| Lys 25 | - | cloning artifact |
| Lys 26 | - | cloning artifact |
| Thr 27 | - | cloning artifact |
| Ser 28 | - | cloning artifact |
| His 495 | - | expression tag |
| His 496 | - | expression tag |
| His 497 | - | expression tag |
| His 498 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 218686.5 | |
| Non-Polymers* | Number of molecules | 20 |
| Total formula weight | 4133.6 | |
| All* | Total formula weight | 222820.2 |
