2PG5

Crystal Structure of Human Microsomal P450 2A6 N297Q

Summary for 2PG5

Entry DOI	10.2210/pdb2pg5/pdb
Related	1Z10 1Z11 2FDU 2FDV 2FDW 2FDY 2PG6 2PG7
Descriptor	Cytochrome P450 2A6, PROTOPORPHYRIN IX CONTAINING FE, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywords	cyp2a6, p450 2a6, p450, monooxygenases, drug metabolizing enzyme, heme, mutant, indole, oxidoreductase
Biological source	Homo sapiens (human)
Cellular location	Endoplasmic reticulum membrane; Peripheral membrane protein: P11509
Total number of polymer chains	4
Total formula weight	221456.88
Authors	Sansen, S.,Hsu, M.H.,Stout, C.D.,Johnson, E.F. (deposition date: 2007-04-06, release date: 2007-07-24, Last modification date: 2023-08-30)
Primary citation	Sansen, S.,Hsu, M.H.,Stout, C.D.,Johnson, E.F. Structural insight into the altered substrate specificity of human cytochrome P450 2A6 mutants. Arch.Biochem.Biophys., 464:197-206, 2007 Cited by PubMed: 17540336 DOI: 10.1016/j.abb.2007.04.028 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.95 Å)

Structure validation