2HAH

The structure of FIV 12S protease in complex with TL-3

Summary for 2HAH

• Entry DOI: 10.2210/pdb2hah/pdb
• Related: 2AZ8 5FIV
• Related PRD ID: PRD_000434
• Descriptor: Protease, benzyl [(1S,4S,7S,8R,9R,10S,13S,16S)-7,10-dibenzyl-8,9-dihydroxy-1,16-dimethyl-4,13-bis(1-methylethyl)-2,5,12,15,18-pentaoxo-20-phenyl-19-oxa-3,6,11,14,17-pentaazaicos-1-yl]carbamate (3 entities in total)
• Functional Keywords: retroviral, protease, aspartyl, feline, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Feline immunodeficiency virus (isolate Petaluma)
• Total number of polymer chains: 1
• Total formula weight: 14135.30

Authors

Heaslet, H.,Lin, Y.C.,Elder, J.H.,Stout, C.D. (deposition date: 2006-06-12, release date: 2007-02-13, Last modification date: 2023-08-30)

• Primary citation: Heaslet, H.,Lin, Y.C.,Tam, K.,Torbett, B.E.,Elder, J.H.,Stout, C.D.; Crystal structure of an FIV/HIV chimeric protease complexed with the broad-based inhibitor, TL-3.; Retrovirology, 4:1-1, 2007; PubMed: 17212810; DOI: 10.1186/1742-4690-4-1

Experimental method

X-RAY DIFFRACTION (1.7 Å)