2HAH
The structure of FIV 12S protease in complex with TL-3
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Protease | polymer | 116 | 13226.2 | 1 | UniProt (P16088) Pfam (PF00077) UniProt (by SIFTS) (Q66972) | Feline immunodeficiency virus (isolate Petaluma) | Retropepsin |
| 2 | B (A) | benzyl [(1S,4S,7S,8R,9R,10S,13S,16S)-7,10-dibenzyl-8,9-dihydroxy-1,16-dimethyl-4,13-bis(1-methylethyl)-2,5,12,15,18-pentaoxo-20-phenyl-19-oxa-3,6,11,14,17-pentaazaicos-1-yl]carbamate | non-polymer | 909.1 | 1 | BIRD (PRD_000434) Chemie (3TL) | |||
| 3 | C (A) | water | water | 18.0 | 120 | Chemie (HOH) |
Sequence modifications
A: 1 - 116 (UniProt: P16088)
| PDB | External Database | Details |
|---|---|---|
| Val 37 | Ile 75 | engineered mutation |
| Met 55 | Asn 93 | engineered mutation |
| Ile 56 | Met 94 | engineered mutation |
| Gly 57 | Ile 95 | engineered mutation |
| Ile 59 | Val 97 | engineered mutation |
| Phe 62 | Gly 100 | engineered mutation |
| Ile 63 | Lys 101 | engineered mutation |
| Thr 97 | Leu 135 | engineered mutation |
| Pro 98 | Ile 136 | engineered mutation |
| Val 99 | Gln 137 | engineered mutation |
| Asn 100 | Pro 138 | engineered mutation |
| Ile 101 | Leu 139 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 13226.2 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 909.1 | |
| All* | Total formula weight | 14135.3 |
