2HI4
Crystal Structure of Human Microsomal P450 1A2 in complex with alpha-naphthoflavone
Summary for 2HI4
Entry DOI | 10.2210/pdb2hi4/pdb |
Related | 1PQ2 1R90 1TQN 1Z10 |
Descriptor | Cytochrome P450 1A2, PROTOPORPHYRIN IX CONTAINING FE, 2-PHENYL-4H-BENZO[H]CHROMEN-4-ONE, ... (4 entities in total) |
Functional Keywords | cyp1a2, p450 1a2, p450, monooxygenase, drug metabolizing enzyme, alpha-naphthoflavone, benzo(h)flavone, 7, 8-benzoflavone, oxidoreductase, heme |
Biological source | Homo sapiens (human) |
Cellular location | Endoplasmic reticulum membrane; Peripheral membrane protein: P05177 |
Total number of polymer chains | 1 |
Total formula weight | 57182.37 |
Authors | Sansen, S.,Yano, J.K.,Reynald, R.L.,Schoch, G.S.,Stout, C.D.,Johnson, E.F. (deposition date: 2006-06-29, release date: 2007-02-20, Last modification date: 2023-08-30) |
Primary citation | Sansen, S.,Yano, J.K.,Reynald, R.L.,Schoch, G.A.,Griffin, K.J.,Stout, C.D.,Johnson, E.F. Adaptations for the oxidation of polycyclic aromatic hydrocarbons exhibited by the structure of human P450 1A2. J.Biol.Chem., 282:14348-14355, 2007 Cited by PubMed: 17311915DOI: 10.1074/jbc.M611692200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.95 Å) |
Structure validation
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