2HI4

Crystal Structure of Human Microsomal P450 1A2 in complex with alpha-naphthoflavone

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004497	molecular_function	monooxygenase activity
A	0005506	molecular_function	iron ion binding
A	0005515	molecular_function	protein binding
A	0005739	cellular_component	mitochondrion
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0006629	biological_process	lipid metabolic process
A	0006631	biological_process	fatty acid metabolic process
A	0006706	biological_process	steroid catabolic process
A	0006805	biological_process	xenobiotic metabolic process
A	0008202	biological_process	steroid metabolic process
A	0008203	biological_process	cholesterol metabolic process
A	0008210	biological_process	estrogen metabolic process
A	0008395	molecular_function	steroid hydroxylase activity
A	0009055	molecular_function	electron transfer activity
A	0009403	biological_process	toxin biosynthetic process
A	0009404	biological_process	toxin metabolic process
A	0009820	biological_process	alkaloid metabolic process
A	0016098	biological_process	monoterpenoid metabolic process
A	0016491	molecular_function	oxidoreductase activity
A	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
A	0016712	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
A	0016829	molecular_function	lyase activity
A	0019369	biological_process	arachidonate metabolic process
A	0019373	biological_process	epoxygenase P450 pathway
A	0019899	molecular_function	enzyme binding
A	0020037	molecular_function	heme binding
A	0032259	biological_process	methylation
A	0032451	molecular_function	demethylase activity
A	0032787	biological_process	monocarboxylic acid metabolic process
A	0034875	molecular_function	caffeine oxidase activity
A	0042178	biological_process	xenobiotic catabolic process
A	0042445	biological_process	hormone metabolic process
A	0042572	biological_process	retinol metabolic process
A	0042759	biological_process	long-chain fatty acid biosynthetic process
A	0043231	cellular_component	intracellular membrane-bounded organelle
A	0046222	biological_process	aflatoxin metabolic process
A	0046872	molecular_function	metal ion binding
A	0070989	biological_process	oxidative demethylation
A	0097267	biological_process	omega-hydroxylase P450 pathway
A	0101020	molecular_function	estrogen 16-alpha-hydroxylase activity
A	0101021	molecular_function	estrogen 2-hydroxylase activity
A	0106256	molecular_function	hydroperoxy icosatetraenoate dehydratase activity
A	0120254	biological_process	olefinic compound metabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	23
Details	BINDING SITE FOR RESIDUE HEM A 900

Chain	Residue
A	ARG108
A	PHE376
A	PHE381
A	LEU382
A	THR385
A	ILE386
A	HIS388
A	GLN411
A	LEU450
A	PHE451
A	ARG456
A	THR124
A	CYS458
A	ILE459
A	ALA464
A	HOH694
A	TRP133
A	ARG137
A	LEU144
A	ILE314
A	ALA317
A	GLY318
A	THR321

---

site_id	AC2
Number of Residues	10
Details	BINDING SITE FOR RESIDUE BHF A 800

Chain	Residue
A	THR118
A	PHE226
A	PHE260
A	ASP313
A	GLY316
A	ALA317
A	ASP320
A	THR321
A	LEU497
A	HOH733

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Functional Information from PROSITE/UniProt

site_id	PS00086
Number of Residues	10
Details	CYTOCHROME_P450 Cytochrome P450 cysteine heme-iron ligand signature. FGmGKRRCIG

Chain	Residue	Details
A	PHE451-GLY460

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	1
Details	Binding site: {"description":"axial binding residue"}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	1
Details	Glycosylation: {"description":"O-linked (GlcNAc) serine","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1akd

Chain	Residue	Details
A	ASP320
A	THR321

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