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2HI4

Crystal Structure of Human Microsomal P450 1A2 in complex with alpha-naphthoflavone

Functional Information from GO Data
ChainGOidnamespacecontents
A0004497molecular_functionmonooxygenase activity
A0005506molecular_functioniron ion binding
A0005515molecular_functionprotein binding
A0005783cellular_componentendoplasmic reticulum
A0005789cellular_componentendoplasmic reticulum membrane
A0006631biological_processfatty acid metabolic process
A0006706biological_processsteroid catabolic process
A0006778biological_processporphyrin-containing compound metabolic process
A0006805biological_processxenobiotic metabolic process
A0008202biological_processsteroid metabolic process
A0008203biological_processcholesterol metabolic process
A0008210biological_processestrogen metabolic process
A0008395molecular_functionsteroid hydroxylase activity
A0009055molecular_functionelectron transfer activity
A0009403biological_processtoxin biosynthetic process
A0009404biological_processtoxin metabolic process
A0009791biological_processpost-embryonic development
A0009820biological_processalkaloid metabolic process
A0010468biological_processregulation of gene expression
A0016020cellular_componentmembrane
A0016098biological_processmonoterpenoid metabolic process
A0016491molecular_functionoxidoreductase activity
A0016705molecular_functionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
A0016712molecular_functionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
A0016829molecular_functionlyase activity
A0018894biological_processdibenzo-p-dioxin metabolic process
A0019369biological_processarachidonic acid metabolic process
A0019373biological_processepoxygenase P450 pathway
A0019899molecular_functionenzyme binding
A0020037molecular_functionheme binding
A0030324biological_processlung development
A0032259biological_processmethylation
A0032451molecular_functiondemethylase activity
A0032787biological_processmonocarboxylic acid metabolic process
A0034875molecular_functioncaffeine oxidase activity
A0042178biological_processxenobiotic catabolic process
A0042445biological_processhormone metabolic process
A0042572biological_processretinol metabolic process
A0042759biological_processlong-chain fatty acid biosynthetic process
A0043231cellular_componentintracellular membrane-bounded organelle
A0045333biological_processcellular respiration
A0046222biological_processaflatoxin metabolic process
A0046872molecular_functionmetal ion binding
A0050665biological_processhydrogen peroxide biosynthetic process
A0070330molecular_functionaromatase activity
A0070989biological_processoxidative demethylation
A0071276biological_processcellular response to cadmium ion
A0097267biological_processomega-hydroxylase P450 pathway
A0101020molecular_functionestrogen 16-alpha-hydroxylase activity
A0101021molecular_functionestrogen 2-hydroxylase activity
A0106256molecular_functionhydroperoxy icosatetraenoate dehydratase activity
Functional Information from PDB Data
site_idAC1
Number of Residues23
DetailsBINDING SITE FOR RESIDUE HEM A 900
ChainResidue
AARG108
APHE376
APHE381
ALEU382
ATHR385
AILE386
AHIS388
AGLN411
ALEU450
APHE451
AARG456
ATHR124
ACYS458
AILE459
AALA464
AHOH694
ATRP133
AARG137
ALEU144
AILE314
AALA317
AGLY318
ATHR321

site_idAC2
Number of Residues10
DetailsBINDING SITE FOR RESIDUE BHF A 800
ChainResidue
ATHR118
APHE226
APHE260
AASP313
AGLY316
AALA317
AASP320
ATHR321
ALEU497
AHOH733

Functional Information from PROSITE/UniProt
site_idPS00086
Number of Residues10
DetailsCYTOCHROME_P450 Cytochrome P450 cysteine heme-iron ligand signature. FGmGKRRCIG
ChainResidueDetails
APHE451-GLY460

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsBINDING: BINDING => ECO:0000305
ChainResidueDetails
AVAL227

site_idSWS_FT_FI2
Number of Residues1
DetailsBINDING: axial binding residue
ChainResidueDetails
AILE459

site_idSWS_FT_FI3
Number of Residues1
DetailsCARBOHYD: O-linked (GlcNAc) serine => ECO:0000250
ChainResidueDetails
AGLN70

Catalytic Information from CSA
site_idCSA1
Number of Residues2
DetailsAnnotated By Reference To The Literature 1akd
ChainResidueDetails
AASP320
ATHR321

224201

PDB entries from 2024-08-28

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