3OGQ

Crystal Structure of 6s-98S FIV Protease with Lopinavir bound

Summary for 3OGQ

• Entry DOI: 10.2210/pdb3ogq/pdb
• Related: 1B11 2HAH 3OGP
• Descriptor: FIV protease, N-{1-BENZYL-4-[2-(2,6-DIMETHYL-PHENOXY)-ACETYLAMINO]-3-HYDROXY-5-PHENYL-PENTYL}-3-METHYL-2-(2-OXO-TETRAHYDRO-PYRIMIDIN-1-YL)-BUTYRAMIDE, DIMETHYL SULFOXIDE, ... (4 entities in total)
• Functional Keywords: aspartyl protease, hiv-like fiv chimera, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Feline immunodeficiency virus (FIV)
• Total number of polymer chains: 2
• Total formula weight: 27241.64

Authors

Lin, Y.-C.,Perryman, A.L.,Elder, J.H.,Stout, C.D. (deposition date: 2010-08-17, release date: 2011-06-08, Last modification date: 2024-02-21)

• Primary citation: Lin, Y.C.,Perryman, A.L.,Olson, A.J.,Torbett, B.E.,Elder, J.H.,Stout, C.D.; Structural basis for drug and substrate specificity exhibited by FIV encoding a chimeric FIV/HIV protease.; Acta Crystallogr.,Sect.D, 67:540-548, 2011; PubMed: 21636894; DOI: 10.1107/S0907444911011681

Experimental method

X-RAY DIFFRACTION (1.8 Å)