3OGQ
Crystal Structure of 6s-98S FIV Protease with Lopinavir bound
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | FIV protease | polymer | 116 | 13228.3 | 2 | UniProt (P16088) Pfam (PF00077) | Feline immunodeficiency virus (FIV) | Protease, Retropepsin |
| 2 | C (A) | N-{1-BENZYL-4-[2-(2,6-DIMETHYL-PHENOXY)-ACETYLAMINO]-3-HYDROXY-5-PHENYL-PENTYL}-3-METHYL-2-(2-OXO-TETRAHYDRO-PYRIMIDIN-1-YL)-BUTYRAMIDE | non-polymer | 628.8 | 1 | Chemie (AB1) | |||
| 3 | D, E (A, B) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 2 | Chemie (DMS) | |||
| 4 | F, G (A, B) | water | water | 18.0 | 145 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 116 (UniProt: P16088)
| PDB | External Database | Details |
|---|---|---|
| Val 37 | Ile 75 | engineered mutation |
| Met 55 | Asn 93 | engineered mutation |
| Ile 59 | Val 97 | engineered mutation |
| Ser 98 | Ile 136 | engineered mutation |
| Val 99 | Gln 137 | engineered mutation |
| Asn 100 | Pro 138 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 26456.6 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 785.1 | |
| All* | Total formula weight | 27241.6 |
