6RCL
 
 | | Crystal structure of REXO2-D199A-AA | | Descriptor: | MAGNESIUM ION, Oligoribonuclease, mitochondrial, ... | | Authors: | Spahr, H, Nicholls, T.J, Larsson, N.G, Gustafsson, C.M. | | Deposit date: | 2019-04-11 | | Release date: | 2019-10-09 | | Last modified: | 2024-05-15 | | Method: | X-RAY DIFFRACTION (1.97 Å) | | Cite: | Dinucleotide Degradation by REXO2 Maintains Promoter Specificity in Mammalian Mitochondria.
Mol.Cell, 76, 2019
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6RCI
 | | Crystal structure of REXO2 | | Descriptor: | Oligoribonuclease, mitochondrial | | Authors: | Spahr, H, Nicholls, T.J, Larsson, N.G, Gustafsson, C.M. | | Deposit date: | 2019-04-11 | | Release date: | 2019-10-09 | | Last modified: | 2024-05-15 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Dinucleotide Degradation by REXO2 Maintains Promoter Specificity in Mammalian Mitochondria.
Mol.Cell, 76, 2019
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6RCN
 | | Crystal structure of REXO2-D199A-dAdA | | Descriptor: | DNA (5'-D(P*AP*A)-3'), MAGNESIUM ION, Oligoribonuclease, ... | | Authors: | Spahr, H, Nicholls, T.J, Larsson, N.G, Gustafsson, C.M. | | Deposit date: | 2019-04-11 | | Release date: | 2019-10-09 | | Last modified: | 2024-05-15 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | Dinucleotide Degradation by REXO2 Maintains Promoter Specificity in Mammalian Mitochondria.
Mol.Cell, 76, 2019
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4FP9
 | | Human MTERF4-NSUN4 protein complex | | Descriptor: | S-ADENOSYLMETHIONINE, SULFATE ION, mTERF domain-containing protein 2, ... | | Authors: | Spahr, H, Hallberg, B.M. | | Deposit date: | 2012-06-21 | | Release date: | 2012-09-12 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Structure of the human MTERF4-NSUN4 protein complex that regulates mitochondrial ribosome biogenesis.
Proc.Natl.Acad.Sci.USA, 109, 2012
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3H0G
 | | RNA Polymerase II from Schizosaccharomyces pombe | | Descriptor: | DNA-directed RNA polymerase II subunit RPB11, DNA-directed RNA polymerase II subunit RPB2, DNA-directed RNA polymerase II subunit RPB3, ... | | Authors: | Spahr, H, Calero, G, Bushnell, D.A, Kornberg, R.D. | | Deposit date: | 2009-04-09 | | Release date: | 2009-08-25 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (3.65 Å) | | Cite: | Schizosacharomyces pombe RNA polymerase II at 3.6-A resolution.
Proc.Natl.Acad.Sci.USA, 106, 2009
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5EKZ
 | | Crystal structure of mouse Taco1 | | Descriptor: | Translational activator of cytochrome c oxidase 1 | | Authors: | Spahr, H, Richman, T.R, Larsson, N.G, Rackham, O, Filipovska, A. | | Deposit date: | 2015-11-04 | | Release date: | 2016-06-29 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Loss of the RNA-binding protein TACO1 causes late-onset mitochondrial dysfunction in mice.
Nat Commun, 7, 2016
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3M66
 | | Crystal structure of human Mitochondrial Transcription Termination Factor 3 | | Descriptor: | mTERF domain-containing protein 1, mitochondrial | | Authors: | Spahr, H, Samuelsson, T, Hallberg, B.M, Gustafsson, C.M. | | Deposit date: | 2010-03-15 | | Release date: | 2010-05-05 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Structure of mitochondrial transcription termination factor 3 reveals a novel nucleic acid-binding domain.
Biochem.Biophys.Res.Commun., 397, 2010
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5ORM
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5ORQ
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5C4X
 | | Crystal structure of a transcribing RNA Polymerase II complex reveals a complete transcription bubble | | Descriptor: | DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, DNA-directed RNA polymerase II subunit RPB2, ... | | Authors: | Barnes, C.O, Calero, M, Malik, I, Spahr, H, Zhang, Q, Pullara, F, Kaplan, C.D, Calero, G. | | Deposit date: | 2015-06-18 | | Release date: | 2015-08-26 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (4 Å) | | Cite: | Crystal Structure of a Transcribing RNA Polymerase II Complex Reveals a Complete Transcription Bubble.
Mol.Cell, 59, 2015
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5C3E
 | | Crystal structure of a transcribing RNA Polymerase II complex reveals a complete transcription bubble | | Descriptor: | DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, DNA-directed RNA polymerase II subunit RPB2, ... | | Authors: | Barnes, C.O, Calero, M, Malik, I, Spahr, H, Zhang, Q, Pullara, F, Kaplan, C.D, Calero, G. | | Deposit date: | 2015-06-17 | | Release date: | 2015-08-26 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (3.7 Å) | | Cite: | Crystal Structure of a Transcribing RNA Polymerase II Complex Reveals a Complete Transcription Bubble.
Mol.Cell, 59, 2015
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5C44
 | | Crystal structure of a transcribing RNA Polymerase II complex reveals a complete transcription bubble | | Descriptor: | DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, DNA-directed RNA polymerase II subunit RPB2, ... | | Authors: | Barnes, C.O, Calero, M, Malik, I, Spahr, H, Zhang, Q, Pullara, F, Kaplan, C.D, Calero, G. | | Deposit date: | 2015-06-17 | | Release date: | 2015-08-26 | | Method: | X-RAY DIFFRACTION (3.95 Å) | | Cite: | Crystal Structure of a Transcribing RNA Polymerase II Complex Reveals a Complete Transcription Bubble.
Mol.Cell, 59, 2015
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5C4J
 | | Crystal structure of a transcribing RNA Polymerase II complex reveals a complete transcription bubble | | Descriptor: | DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, DNA-directed RNA polymerase II subunit RPB2, ... | | Authors: | Barnes, C.O, Calero, M, Malik, I, Spahr, H, Zhang, Q, Pullara, F, Kaplan, C.D, Calero, G. | | Deposit date: | 2015-06-18 | | Release date: | 2015-08-26 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (4 Å) | | Cite: | Crystal Structure of a Transcribing RNA Polymerase II Complex Reveals a Complete Transcription Bubble.
Mol.Cell, 59, 2015
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1I1B
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1RDH
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2AYW
 | | Crystal Structure of the complex formed between trypsin and a designed synthetic highly potent inhibitor in the presence of benzamidine at 0.97 A resolution | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-[2-({[4-(DIAMINOMETHYL)PHENYL]AMINO}CARBONYL)-6-METHOXYPYRIDIN-3-YL]-5-{[(1-FORMYL-2,2-DIMETHYLPROPYL)AMINO]CARBONYL}BENZOIC ACID, BENZAMIDINE, ... | | Authors: | Sherawat, M, Kaur, P, Perbandt, M, Betzel, C, Slusarchyk, W.A, Bisacchi, G.S, Chang, C, Jacobson, B.L, Einspahr, H.M, Singh, T.P. | | Deposit date: | 2005-09-09 | | Release date: | 2006-01-17 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (0.97 Å) | | Cite: | Structure of the complex of trypsin with a highly potent synthetic inhibitor at 0.97 A resolution.
Acta Crystallogr.,Sect.D, 63, 2007
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2LTN
 | | DESIGN, EXPRESSION, AND CRYSTALLIZATION OF RECOMBINANT LECTIN FROM THE GARDEN PEA (PISUM SATIVUM) | | Descriptor: | CALCIUM ION, MANGANESE (II) ION, PEA LECTIN, ... | | Authors: | Suddath, F.L, Phillips, S.R, Einspahr, H. | | Deposit date: | 1990-06-26 | | Release date: | 1990-07-15 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Design, expression, and crystallization of recombinant lectin from the garden pea (Pisum sativum).
J.Biol.Chem., 264, 1989
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1RIN
 | | X-RAY CRYSTAL STRUCTURE OF A PEA LECTIN-TRIMANNOSIDE COMPLEX AT 2.6 ANGSTROMS RESOLUTION | | Descriptor: | CALCIUM ION, MANGANESE (II) ION, PEA LECTIN, ... | | Authors: | Rini, J.M, Hardman, K.D, Einspahr, H, Suddath, F.L, Carver, J.P. | | Deposit date: | 1993-01-27 | | Release date: | 1993-10-31 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | X-ray crystal structure of a pea lectin-trimannoside complex at 2.6 A resolution.
J.Biol.Chem., 268, 1993
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1PPA
 | | THE CRYSTAL STRUCTURE OF A LYSINE 49 PHOSPHOLIPASE A2 FROM THE VENOM OF THE COTTONMOUTH SNAKE AT 2.0 ANGSTROMS RESOLUTION | | Descriptor: | ANILINE, PHOSPHOLIPASE A2 | | Authors: | Holland, D.R, Clancy, L.L, Muchmore, S.W, Rydel, T.J, Einspahr, H.M, Finzel, B.C, Heinrikson, R.L, Watenpaugh, K.D. | | Deposit date: | 1991-10-29 | | Release date: | 1994-01-31 | | Last modified: | 2024-06-05 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | The crystal structure of a lysine 49 phospholipase A2 from the venom of the cottonmouth snake at 2.0-A resolution.
J.Biol.Chem., 265, 1990
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2IRT
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1R6G
 | | Crystal structure of the thyroid hormone receptor beta ligand binding domain in complex with a beta selective compound | | Descriptor: | 2-[3,5-DIBROMO-4-(4-HYDROXY-3-{HYDROXY[(2-PHENYLETHYL)AMINO]METHYL}PHENOXY)PHENYL]ETHANE-1,1-DIOL, Thyroid hormone receptor beta-1 | | Authors: | Hangeland, J.J, Dejneka, T, Friends, T.J, Devasthale, P, Mellstrom, K, Sandberg, J, Grynfarb, M, Doweyko, A.M, Sack, J.S, Einspahr, H, Farnegardh, M, Husman, B, Ljunggren, J, Koehler, K, Sheppard, C, Malm, J, Ryono, D.E. | | Deposit date: | 2003-10-15 | | Release date: | 2005-02-15 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Thyroid receptor ligands. Part 2: Thyromimetics with improved selectivity for the thyroid hormone receptor beta.
Bioorg.Med.Chem.Lett., 14, 2004
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2ICA
 | | CD11a (LFA1) I-domain complexed with BMS-587101 aka 5-[(5S, 9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro [4.4]non-7-yl]methyl]-3-thiophenecarboxylicacid | | Descriptor: | 5-[(5S,9R)-9-(4-CYANOPHENYL)-3-(3,5-DICHLOROPHENYL)-1-METHYL-2,4-DIOXO-1,3,7-TRIAZASPIRO [4.4]NON-7-YL]METHYL]-3-THIOPHENECARBOXYLICACID, Integrin alpha-L | | Authors: | Sheriff, S, Einspahr, H. | | Deposit date: | 2006-09-12 | | Release date: | 2006-12-19 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.56 Å) | | Cite: | Discovery and Development of 5-[(5S,9R)-9- (4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1- methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]non- 7-yl-methyl]-3-thiophenecarboxylic acid (BMS-587101)-A Small Molecule Antagonist Leukocyte Function Associated Antigen-1.
J.Med.Chem., 49, 2006
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