7UI0
 
 | | Post-fusion ectodomain of HSV-1 gB in complex with HSV010-13 Fab | | 分子名称: | Envelope glycoprotein B, HSV10-13 Fab Heavy chain, HSV10-13 Light chain | | 著者 | Windsor, I.W, Kong, S.L, Garforth, S.J, Almo, S.C, Harrison, S.C. | | 登録日 | 2022-03-28 | | 公開日 | 2023-02-08 | | 最終更新日 | 2023-02-15 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | A non-neutralizing glycoprotein B monoclonal antibody protects against herpes simplex virus disease in mice.
J.Clin.Invest., 133, 2023
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7UHZ
 | | Post-fusion ectodomain of HSV-1 gB in complex with BMPC-23 Fab | | 分子名称: | BMPC-23 Fab Heavy chain, BMPC-23 Fab Light chain, Envelope glycoprotein B | | 著者 | Windsor, I.W, Kong, S.L, Garforth, S.J, Almo, S.C, Harrison, S.C. | | 登録日 | 2022-03-28 | | 公開日 | 2023-02-08 | | 最終更新日 | 2023-02-15 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | A non-neutralizing glycoprotein B monoclonal antibody protects against herpes simplex virus disease in mice.
J.Clin.Invest., 133, 2023
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3OGA
 | | 1.75 Angstrom resolution crystal structure of a putative NTP pyrophosphohydrolase (yfaO) from Salmonella typhimurium LT2 | | 分子名称: | BETA-MERCAPTOETHANOL, Nucleoside triphosphatase nudI, PHOSPHATE ION | | 著者 | Halavaty, A.S, Minasov, G, Shuvalova, L, Winsor, J, Dubrovska, I, Peterson, S, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID) | | 登録日 | 2010-08-16 | | 公開日 | 2010-10-06 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | 1.75 Angstrom resolution crystal structure of a putative NTP pyrophosphohydrolase (yfaO) from Salmonella typhimurium LT2
To be Published
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3PAJ
 | | 2.00 Angstrom resolution crystal structure of a quinolinate phosphoribosyltransferase from Vibrio cholerae O1 biovar eltor str. N16961 | | 分子名称: | MAGNESIUM ION, Nicotinate-nucleotide pyrophosphorylase, carboxylating | | 著者 | Halavaty, A.S, Minasov, G, Winsor, J, Dubrovska, I, Shuvalova, L, Peterson, S, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID) | | 登録日 | 2010-10-19 | | 公開日 | 2010-11-03 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | 2.00 Angstrom resolution crystal structure of a quinolinate phosphoribosyltransferase from Vibrio cholerae O1 biovar eltor str. N16961
To be Published
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4BY2
 | | SAS-4 (dCPAP) TCP domain in complex with a Proline Rich Motif of Ana2 (dSTIL) of Drosophila Melanogaster | | 分子名称: | 1,2-ETHANEDIOL, ANASTRAL SPINDLE 2, SAS 4 | | 著者 | Cottee, M.A, Muschalik, N, Wong, Y.L, Johnson, C.M, Johnson, S, Andreeva, A, Oegema, K, Lea, S.M, Raff, J.W, van Breugel, M. | | 登録日 | 2013-07-17 | | 公開日 | 2013-09-18 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.57 Å) | | 主引用文献 | Crystal structures of the CPAP/STIL complex reveal its role in centriole assembly and human microcephaly.
Elife, 2, 2013
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5SYR
 | | Crystal Structure of ATPase delta1-79 Spa47 R350A | | 分子名称: | Probable ATP synthase SpaL/MxiB, SULFATE ION | | 著者 | Morales, Y, Johnson, S.J, Burgess, J.L, Burgess, R.A, Dickenson, N.E. | | 登録日 | 2016-08-11 | | 公開日 | 2016-11-02 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Structural and Biochemical Characterization of Spa47 Provides Mechanistic Insight into Type III Secretion System ATPase Activation and Shigella Virulence Regulation.
J. Biol. Chem., 291, 2016
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2FX7
 | | Crystal structure of hiv-1 neutralizing human fab 4e10 in complex with a 16-residue peptide encompassing the 4e10 epitope on gp41 | | 分子名称: | Fab 4E10, Fragment of HIV glycoprotein (GP41), GLYCEROL | | 著者 | Cardoso, R.M.F, Brunel, F.M, Ferguson, S, Burton, D.R, Dawson, P.E, Wilson, I.A. | | 登録日 | 2006-02-03 | | 公開日 | 2006-12-19 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.76 Å) | | 主引用文献 | Structural basis of enhanced binding of extended and helically constrained peptide epitopes of the broadly neutralizing HIV-1 antibody 4E10.
J.Mol.Biol., 365, 2007
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5SWJ
 | | Crystal Structure of ATPase delta1-79 Spa47 | | 分子名称: | Probable ATP synthase SpaL/MxiB, SULFATE ION | | 著者 | Morales, Y, Johnson, S.J, Burgess, J.L, Burgess, R.A, Dickenson, N.E. | | 登録日 | 2016-08-08 | | 公開日 | 2016-11-02 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.401 Å) | | 主引用文献 | Structural and Biochemical Characterization of Spa47 Provides Mechanistic Insight into Type III Secretion System ATPase Activation and Shigella Virulence Regulation.
J. Biol. Chem., 291, 2016
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5SWL
 | | Crystal Structure of ATPase delta1-79 Spa47 E188A | | 分子名称: | Probable ATP synthase SpaL/MxiB, SULFATE ION | | 著者 | Morales, Y, Johnson, S.J, Burgess, J.L, Burgess, R.A, Dickenson, N.E. | | 登録日 | 2016-08-08 | | 公開日 | 2016-11-02 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Structural and Biochemical Characterization of Spa47 Provides Mechanistic Insight into Type III Secretion System ATPase Activation and Shigella Virulence Regulation.
J. Biol. Chem., 291, 2016
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5SYP
 | | Crystal Structure of ATPase delta1-79 Spa47 K165A | | 分子名称: | Probable ATP synthase SpaL/MxiB, SULFATE ION | | 著者 | Morales, Y, Johnson, S.J, Burgess, J.L, Burgess, R.A, Dickenson, N.E. | | 登録日 | 2016-08-11 | | 公開日 | 2016-11-02 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | Structural and Biochemical Characterization of Spa47 Provides Mechanistic Insight into Type III Secretion System ATPase Activation and Shigella Virulence Regulation.
J. Biol. Chem., 291, 2016
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6XPX
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6XPO
 | | Influenza hemagglutinin A/Bangkok/01/1979(H3N2) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, ... | | 著者 | McCarthy, K.R, Harrison, S.C. | | 登録日 | 2020-07-08 | | 公開日 | 2021-05-19 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | A Prevalent Focused Human Antibody Response to the Influenza Virus Hemagglutinin Head Interface.
Mbio, 12, 2021
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6V05
 | | Cryo-EM structure of a substrate-engaged Bam complex | | 分子名称: | Outer membrane protein assembly factor BamA, Outer membrane protein assembly factor BamA,Outer membrane protein assembly factor BamA,Outer membrane protein assembly factor BamA,Outer membrane protein assembly factor BamA, Outer membrane protein assembly factor BamB, ... | | 著者 | Tomasek, D, Rawson, S, Lee, J, Wzorek, J.S, Harrison, S.C, Li, Z, Kahne, D. | | 登録日 | 2019-11-18 | | 公開日 | 2020-06-10 | | 最終更新日 | 2020-07-29 | | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | | 主引用文献 | Structure of a nascent membrane protein as it folds on the BAM complex.
Nature, 583, 2020
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6PPE
 | | ClpP and ClpX IGF loop in ClpX-ClpP complex with D7 symmetry | | 分子名称: | ATP-dependent Clp protease ATP-binding subunit ClpX, ATP-dependent Clp protease proteolytic subunit | | 著者 | Fei, X, Jenni, S, Harrison, S.C, Sauer, R.T. | | 登録日 | 2019-07-06 | | 公開日 | 2020-03-11 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (3.19 Å) | | 主引用文献 | Structures of the ATP-fueled ClpXP proteolytic machine bound to protein substrate.
Elife, 9, 2020
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6Q0J
 | | Structure of a MAPK pathway complex | | 分子名称: | 14-3-3 protein zeta, 5-[(2-fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)imidazo[1,5-a]pyridine-6-carboxamide, Dual specificity mitogen-activated protein kinase kinase 1, ... | | 著者 | Park, E, Rawson, S, Jeon, H, Eck, M.J. | | 登録日 | 2019-08-01 | | 公開日 | 2019-10-09 | | 最終更新日 | 2020-04-22 | | 実験手法 | ELECTRON MICROSCOPY (4.9 Å) | | 主引用文献 | Architecture of autoinhibited and active BRAF-MEK1-14-3-3 complexes.
Nature, 575, 2019
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6Q1F
 | | Atomic structure of the Human Herpesvirus 6B Capsid and Capsid-Associated Tegument Complexes | | 分子名称: | Large structural phosphoprotein, Major capsid protein, Small capsomere-interacting protein, ... | | 著者 | Zhang, Y.B, Liu, W, Li, Z.H, Kumar, V, Alvarez-Cabrera, A.L, Leibovitch, E, Cui, Y.X, Mei, Y, Bi, G.Q, Jacobson, S, Zhou, Z.H. | | 登録日 | 2019-08-03 | | 公開日 | 2019-12-11 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (9 Å) | | 主引用文献 | Atomic structure of the human herpesvirus 6B capsid and capsid-associated tegument complexes.
Nat Commun, 10, 2019
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7SXL
 | | Plasmodium falciparum apicoplast DNA polymerase (exo-minus) without affinity tag | | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Nieto, N, Chheda, P, Kerns, R, Nelson, S, Honzatko, R. | | 登録日 | 2021-11-23 | | 公開日 | 2022-10-26 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Promising antimalarials targeting apicoplast DNA polymerase from Plasmodium falciparum.
Eur.J.Med.Chem., 243, 2022
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7TEO
 | | Cryo-EM structure of the 20S Alpha 3 Deletion proteasome core particle in complex with FUB1 | | 分子名称: | Proteasome subunit alpha type-1, Proteasome subunit alpha type-2, Proteasome subunit alpha type-4, ... | | 著者 | Walsh Jr, R.M, Rawson, S, Schnell, H.M, Hanna, J. | | 登録日 | 2022-01-05 | | 公開日 | 2022-08-10 | | 最終更新日 | 2024-02-28 | | 実験手法 | ELECTRON MICROSCOPY (2.97 Å) | | 主引用文献 | Yeast PI31 inhibits the proteasome by a direct multisite mechanism.
Nat.Struct.Mol.Biol., 29, 2022
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7TEJ
 | | Cryo-EM structure of the 20S Alpha 3 Deletion proteasome core particle | | 分子名称: | Proteasome subunit alpha type-1, Proteasome subunit alpha type-2, Proteasome subunit alpha type-4, ... | | 著者 | Walsh Jr, R.M, Rawson, S, Schnell, H.M, Hanna, J. | | 登録日 | 2022-01-05 | | 公開日 | 2022-08-10 | | 最終更新日 | 2024-02-28 | | 実験手法 | ELECTRON MICROSCOPY (2.74 Å) | | 主引用文献 | Yeast PI31 inhibits the proteasome by a direct multisite mechanism.
Nat.Struct.Mol.Biol., 29, 2022
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8ASG
 | | Structure of the SFTSV L protein bound in a resting state [RESTING] | | 分子名称: | MAGNESIUM ION, RNA (5'-R(*AP*CP*AP*CP*AP*GP*AP*GP*AP*CP*GP*CP*CP*CP*AP*GP*AP*UP*GP*A*)-3'), RNA (5'-R(*GP*AP*UP*CP*UP*GP*GP*GP*CP*GP*GP*UP*CP*UP*UP*UP*GP*UP*GP*U*)-3'), ... | | 著者 | Williams, H.M, Thorkelsson, S.R, Vogel, D, Milewski, M, Busch, C, Cusack, S, Grunewald, K, Quemin, E.R.J, Rosenthal, M. | | 登録日 | 2022-08-19 | | 公開日 | 2023-01-18 | | 最終更新日 | 2024-07-24 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Structural insights into viral genome replication by the severe fever with thrombocytopenia syndrome virus L protein.
Nucleic Acids Res., 51, 2023
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8AS6
 | | Structure of the SFTSV L protein bound to 5' cRNA hook [5' HOOK] | | 分子名称: | RNA (5'-R(*AP*CP*AP*CP*AP*GP*AP*GP*AP*CP*GP*CP*CP*C)-3'), RNA-dependent RNA-polymerase L protein | | 著者 | Williams, H.M, Thorkelsson, S.R, Vogel, D, Milewski, M, Busch, C, Cusack, S, Grunewald, K, Quemin, E.R.J, Rosenthal, M. | | 登録日 | 2022-08-18 | | 公開日 | 2023-01-18 | | 最終更新日 | 2024-07-24 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Structural insights into viral genome replication by the severe fever with thrombocytopenia syndrome virus L protein.
Nucleic Acids Res., 51, 2023
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6CRB
 | | Ternary complex crystal structure of DNA polymerase Beta with a dideoxy terminated primer with CF2, beta, gamma dATP analogue | | 分子名称: | 9-{2-deoxy-5-O-[(S)-{[(S)-[difluoro(phosphono)methyl](hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]-alpha-D-erythro-pentofuranosyl}-9H-purin-6-amine, DNA polymerase beta, Downstream Primer Strand, ... | | 著者 | Batra, V.K, Wilson, S.H. | | 登録日 | 2018-03-16 | | 公開日 | 2018-07-18 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.151 Å) | | 主引用文献 | Mapping Functional Substrate-Enzyme Interactions in the pol beta Active Site through Chemical Biology: Structural Responses to Acidity Modification of Incoming dNTPs.
Biochemistry, 57, 2018
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4UBC
 | | DNA polymerase beta substrate complex with a templating cytosine and incoming 8-oxodGTP, 0 s | | 分子名称: | 5'-D(*CP*CP*GP*AP*CP*CP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*C)-3', 5'-D(P*GP*TP*CP*GP*G)-3', ... | | 著者 | Freudenthal, B.D, Wilson, S.H, Beard, W.A. | | 登録日 | 2014-08-12 | | 公開日 | 2014-11-12 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Uncovering the polymerase-induced cytotoxicity of an oxidized nucleotide.
Nature, 517, 2015
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7U8Y
 | | TREX1 Structural Studies Capture Small Molecule Inhibition and Implicate Novel DNA Dynamics | | 分子名称: | ALIZARIN RED, MANGANESE (II) ION, Three-prime repair exonuclease 1 | | 著者 | Hemphill, W.O, Harvey, S.E, Simpson, S.R, Smalley, T.L, Salsbury, F.R, Perrino, F.W, Hollis, T. | | 登録日 | 2022-03-09 | | 公開日 | 2023-03-15 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.22 Å) | | 主引用文献 | TREX1 Structural Studies Capture Small Molecule Inhibition and Implicate Novel DNA Dynamics
to be published
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4UAW
 | | DNA polymerase beta substrate complex with a templating adenine and incoming 8-oxodGTP, 0 s | | 分子名称: | 5'-D(*CP*CP*GP*AP*CP*AP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*C)-3', 5'-D(P*GP*TP*CP*GP*G)-3', ... | | 著者 | Freudenthal, B.D, Wilson, S.H, Beard, W.A. | | 登録日 | 2014-08-11 | | 公開日 | 2014-11-12 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Uncovering the polymerase-induced cytotoxicity of an oxidized nucleotide.
Nature, 517, 2015
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