7SXL

Plasmodium falciparum apicoplast DNA polymerase (exo-minus) without affinity tag

Summary for 7SXL

• Entry DOI: 10.2210/pdb7sxl/pdb
• Related: 5DKU
• Descriptor: Plastid replication-repair enzyme, GLYCEROL, SODIUM ION, ... (7 entities in total)
• Functional Keywords: dna polymerase, exonulease, apicoplast, replication, transferase
• Biological source: Plasmodium falciparum (isolate 3D7)
• Total number of polymer chains: 2
• Total formula weight: 149280.43

Authors

Nieto, N.,Chheda, P.,Kerns, R.,Nelson, S.,Honzatko, R. (deposition date: 2021-11-23, release date: 2022-10-26, Last modification date: 2023-10-18)

• Primary citation: Chheda, P.R.,Nieto, N.,Kaur, S.,Beck, J.M.,Beck, J.R.,Honzatko, R.,Kerns, R.J.,Nelson, S.W.; Promising antimalarials targeting apicoplast DNA polymerase from Plasmodium falciparum.; Eur.J.Med.Chem., 243:114751-114751, 2022; PubMed: 36191407; DOI: 10.1016/j.ejmech.2022.114751

Experimental method

X-RAY DIFFRACTION (2.7 Å)