2FX7

Crystal structure of hiv-1 neutralizing human fab 4e10 in complex with a 16-residue peptide encompassing the 4e10 epitope on gp41

Summary for 2FX7

Entry DOI	10.2210/pdb2fx7/pdb
Related	1TZG 2FX8 2FX9
Descriptor	Fab 4E10, Fragment of HIV glycoprotein (GP41), GLYCEROL, ... (5 entities in total)
Functional Keywords	immunoglobulin fold, beta-sandwich, antibody-epitope complex, immune system
Biological source	Homo sapiens (human) More
Cellular location	Transmembrane protein gp41: Virion membrane; Single-pass type I membrane protein. Surface protein gp120: Virion membrane; Peripheral membrane protein: P05880
Total number of polymer chains	3
Total formula weight	49562.41
Authors	Cardoso, R.M.F.,Brunel, F.M.,Ferguson, S.,Burton, D.R.,Dawson, P.E.,Wilson, I.A. (deposition date: 2006-02-03, release date: 2006-12-19, Last modification date: 2023-08-30)
Primary citation	Cardoso, R.M.,Brunel, F.M.,Ferguson, S.,Zwick, M.,Burton, D.R.,Dawson, P.E.,Wilson, I.A. Structural basis of enhanced binding of extended and helically constrained peptide epitopes of the broadly neutralizing HIV-1 antibody 4E10. J.Mol.Biol., 365:1533-1544, 2007 Cited by PubMed: 17125793 DOI: 10.1016/j.jmb.2006.10.088 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.76 Å)

Structure validation