7U8Y

TREX1 Structural Studies Capture Small Molecule Inhibition and Implicate Novel DNA Dynamics

Summary for 7U8Y

• Entry DOI: 10.2210/pdb7u8y/pdb
• Descriptor: Three-prime repair exonuclease 1, ALIZARIN RED, MANGANESE (II) ION, ... (4 entities in total)
• Functional Keywords: inhibitor, exonuclease, immunotherapy, complex, dna binding protein, hydrolase-inhibitor complex, hydrolase/inhibitor
• Biological source: Mus musculus (house mouse)
• Total number of polymer chains: 2
• Total formula weight: 51678.12

Authors

Hemphill, W.O.,Harvey, S.E.,Simpson, S.R.,Smalley, T.L.,Salsbury, F.R.,Perrino, F.W.,Hollis, T. (deposition date: 2022-03-09, release date: 2023-03-15, Last modification date: 2024-12-25)

• Primary citation: Hemphill, W.O.,Harvey, S.E.,Simpson, S.R.,Smalley, T.L.,Salsbury, F.R.,Perrino, F.W.,Hollis, T.; TREX1 Structural Studies Capture Small Molecule Inhibition and Implicate Novel DNA Dynamics; to be published,

Experimental method

X-RAY DIFFRACTION (2.22 Å)