1Z57
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![BU of 1z57 by Molmil](/molmil-images/mine/1z57) | Crystal structure of human CLK1 in complex with 10Z-Hymenialdisine | Descriptor: | DEBROMOHYMENIALDISINE, Dual specificity protein kinase CLK1 | Authors: | Debreczeni, J, Das, S, Knapp, S, Bullock, A, Guo, K, Amos, A, Fedorov, O, Edwards, A, Sundstrom, M, von Delft, F, Niesen, F.H, Ball, L, Sobott, F, Arrowsmith, C, Structural Genomics Consortium (SGC) | Deposit date: | 2005-03-17 | Release date: | 2005-04-12 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Kinase domain insertions define distinct roles of CLK kinases in SR protein phosphorylation. Structure, 17, 2009
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1ZW5
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![BU of 1zw5 by Molmil](/molmil-images/mine/1zw5) | X-ray structure of Farnesyl diphosphate synthase protein | Descriptor: | 3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE, MAGNESIUM ION, ZOLEDRONIC ACID, ... | Authors: | Kavanagh, K.L, Guo, K, Wu, X, von Delft, F, Arrowsmith, C, Sundstrom, M, Edwards, A, Oppermann, U, Structural Genomics Consortium (SGC) | Deposit date: | 2005-06-03 | Release date: | 2005-06-28 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs. Proc.Natl.Acad.Sci.USA, 103, 2006
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2O2V
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![BU of 2o2v by Molmil](/molmil-images/mine/2o2v) | Crystal Structure of the Complex of Human Mitogen Activated Protein Kinase Kinase 5 Phox Domain (MAP2K5-phox) with Human Mitogen Activated Protein Kinase Kinase Kinase 3 (MAP3K3B-phox) | Descriptor: | Dual specificity mitogen-activated protein kinase kinase 5, Mitogen-activated protein kinase kinase kinase 3 | Authors: | Filippakopoulos, P, Savitsky, P, Ugochukwu, E, Edwards, A, Arrowsmith, C, Sundstrom, M, von Delft, F, Knapp, S, Structural Genomics Consortium (SGC) | Deposit date: | 2006-11-30 | Release date: | 2006-12-12 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.83 Å) | Cite: | Crystal Structure of the Complex of Human Mitogen Activated Protein Kinase Kinase 5 Phox Domain (MAP2K5-phox) with Human Mitogen Activated Protein Kinase Kinase Kinase 3 (MAP3K3B-phox) To be Published
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2O23
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![BU of 2o23 by Molmil](/molmil-images/mine/2o23) | The structure of wild-type human HADH2 (17beta-hydroxysteroid dehydrogenase type 10) bound to NAD+ at 1.2 A | Descriptor: | GLYCEROL, HADH2 protein, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | Authors: | Kavanagh, K.L, Shafqat, N, Scholer, K, Debreczeni, J, Zschocke, J, von Delft, F, Weigelt, J, Arrowsmith, C, Sundstrom, M, Edwards, A, Oppermann, U, Structural Genomics Consortium (SGC) | Deposit date: | 2006-11-29 | Release date: | 2006-12-12 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | The structure of wild-type human HADH2 (17beta-hydroxysteroid dehydrogenase type 10) bound to NAD+ at 1.2 A To be Published
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6QY9
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![BU of 6qy9 by Molmil](/molmil-images/mine/6qy9) | Human CSNK2A2 bound to a Pyrrolo[2,3-d]pyrimidinyl inhibitor | Descriptor: | 1,2-ETHANEDIOL, 3-[3-[2-[(3,4,5-trimethoxyphenyl)amino]pyrrolo[2,3-d]pyrimidin-7-yl]phenyl]propanenitrile, CHLORIDE ION, ... | Authors: | Abdul Azeez, K.R, Sorrell, F.J, Krojer, T, Bountra, C, Edwards, A.M, Arrowsmith, C, Knapp, S, Elkins, J.M. | Deposit date: | 2019-03-08 | Release date: | 2019-04-17 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Human CSNK2A2 bound to a Pyrrolo[2,3-d]pyrimidinyl inhibitor To Be Published
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6QY8
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![BU of 6qy8 by Molmil](/molmil-images/mine/6qy8) | Human CSNK2A2 bound to ERB-041 | Descriptor: | 2-(3-FLUORO-4-HYDROXYPHENYL)-7-VINYL-1,3-BENZOXAZOL-5-OL, Casein kinase II subunit alpha' | Authors: | Abdul Azeez, K.R, Sorrell, F.J, Krojer, T, Bountra, C, Edwards, A.M, Arrowsmith, C, Knapp, S, Elkins, J.M. | Deposit date: | 2019-03-08 | Release date: | 2020-03-25 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | CSNK2A1 bound to ERB-041 To Be Published
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6QY7
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![BU of 6qy7 by Molmil](/molmil-images/mine/6qy7) | Human CSNK2A1 bound to ERB-041 | Descriptor: | 2-(3-FLUORO-4-HYDROXYPHENYL)-7-VINYL-1,3-BENZOXAZOL-5-OL, CHLORIDE ION, Casein kinase II subunit alpha | Authors: | Abdul Azeez, K.R, Sorrell, F.J, Krojer, T, Bountra, C, Edwards, A.M, Arrowsmith, C, Knapp, S, Elkins, J.M. | Deposit date: | 2019-03-08 | Release date: | 2020-03-25 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | CSNK2A1 bound to ERB-041 To Be Published
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1YDE
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![BU of 1yde by Molmil](/molmil-images/mine/1yde) | Crystal Structure of Human Retinal Short-Chain Dehydrogenase/Reductase 3 | Descriptor: | Retinal dehydrogenase/reductase 3 | Authors: | Lukacik, P, Bunkozci, G, Kavanagh, K, Sundstrom, M, Arrowsmith, C, Edwards, A, von Delft, F, Oppermann, U, Structural Genomics Consortium (SGC) | Deposit date: | 2004-12-23 | Release date: | 2005-01-18 | Last modified: | 2012-03-14 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural and biochemical characterization of human orphan DHRS10 reveals a novel cytosolic enzyme with steroid dehydrogenase activity. Biochem.J., 402, 2007
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6GQD
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![BU of 6gqd by Molmil](/molmil-images/mine/6gqd) | Structure of human galactose-1-phosphate uridylyltransferase (GALT), with crystallization epitope mutations A21Y:A22T:T23P:R25L | Descriptor: | 1,2-ETHANEDIOL, 5,6-DIHYDROURIDINE-5'-MONOPHOSPHATE, Galactose-1-phosphate uridylyltransferase, ... | Authors: | Fairhead, M, Strain-Damerell, C, Kopec, J, Bezerra, G.A, Zhang, M, Burgess-Brown, N, von Delft, F, Arrowsmith, C, Edwards, A, Bountra, C, Yue, W.W, Structural Genomics Consortium (SGC) | Deposit date: | 2018-06-07 | Release date: | 2018-07-18 | Method: | X-RAY DIFFRACTION (1.523 Å) | Cite: | Structure of human galactose-1-phosphate uridylyltransferase (GALT), with crystallization epitope mutations A21Y:A22T:T23P:R25L To Be Published
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1YV5
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![BU of 1yv5 by Molmil](/molmil-images/mine/1yv5) | Human farnesyl diphosphate synthase complexed with Mg and risedronate | Descriptor: | 1-HYDROXY-2-(3-PYRIDINYL)ETHYLIDENE BIS-PHOSPHONIC ACID, Farnesyl pyrophosphate synthetase, MAGNESIUM ION, ... | Authors: | Kavanagh, K.L, Guo, K, Von Delft, F, Arrowsmith, C, Sundstrom, M, Edwards, A, Oppermann, U, Structural Genomics Consortium (SGC) | Deposit date: | 2005-02-15 | Release date: | 2005-03-01 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs. Proc.Natl.Acad.Sci.USA, 103, 2006
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1ZIV
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![BU of 1ziv by Molmil](/molmil-images/mine/1ziv) | Catalytic Domain of Human Calpain-9 | Descriptor: | BETA-MERCAPTOETHANOL, CALCIUM ION, Calpain 9 | Authors: | Walker, J.R, Davis, T, Newman, E.M, Mackenzie, F, Dong, A, Choe, J, Arrowsmith, C, Sundstrom, M, Edwards, A, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC) | Deposit date: | 2005-04-27 | Release date: | 2005-07-05 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.31 Å) | Cite: | The crystal structures of human calpains 1 and 9 imply diverse mechanisms of action and auto-inhibition. J.Mol.Biol., 366, 2007
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2A8B
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![BU of 2a8b by Molmil](/molmil-images/mine/2a8b) | Crystal Structure of the Catalytic Domain of Human Tyrosine Phosphatase Receptor, Type R | Descriptor: | CHLORIDE ION, Receptor-type tyrosine-protein phosphatase R | Authors: | Ugochukwu, E, Eswaran, J, Barr, A, Longman, E, Arrowsmith, C, Edwards, A, Sundstrom, M, von Delft, F, Knapp, S, Structural Genomics Consortium (SGC) | Deposit date: | 2005-07-07 | Release date: | 2005-07-19 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal structures and inhibitor identification for PTPN5, PTPRR and PTPN7: a family of human MAPK-specific protein tyrosine phosphatases. Biochem.J., 395, 2006
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1TXJ
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![BU of 1txj by Molmil](/molmil-images/mine/1txj) | Crystal structure of translationally controlled tumour-associated protein (TCTP) from Plasmodium knowlesi | Descriptor: | translationally controlled tumour-associated protein (TCTP) from Plasmodium knowlesi, PKN_PFE0545c | Authors: | Walker, J.R, Vedadi, M, Sharma, S, Houston, S, Lew, J, Amani, M, Wasney, G, Skarina, T, Bray, J, Sundstrom, M, Arrowsmith, C, Edwards, A, Hui, R, Structural Genomics Consortium (SGC) | Deposit date: | 2004-07-05 | Release date: | 2004-07-20 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Genome-scale protein expression and structural biology of Plasmodium falciparum and related Apicomplexan organisms. Mol.Biochem.Parasitol., 151, 2007
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2KZ6
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![BU of 2kz6 by Molmil](/molmil-images/mine/2kz6) | Solution structure of protein CV0426 from Chromobacterium violaceum, Northeast structural genomics consortium (NESG) target CVT2 | Descriptor: | Uncharacterized protein | Authors: | Lemak, A, Yee, A, Lee, H, Semesi, A, Prestegard, J, Montelione, G.T, Arrowsmith, C, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2010-06-11 | Release date: | 2010-06-30 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Solution structure of protein CV0426 from Chromobacterium violaceum To be Published
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2KZ4
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![BU of 2kz4 by Molmil](/molmil-images/mine/2kz4) | Solution structure of protein SF1141 from Shigella flexneri 2a, Northeast structural genomics consortium (NESG) target SFT2 | Descriptor: | Putative head-tail adaptor | Authors: | Lemak, A, Yee, A, Garcia, M, Lee, H.-W, Prestegard, J, Montelione, G.T, Arrowsmith, C, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2010-06-11 | Release date: | 2010-07-07 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Solution structure of protein SF1141 from Shigella flexneri 2a To be Published
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2A9U
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![BU of 2a9u by Molmil](/molmil-images/mine/2a9u) | Structure of the N-terminal domain of Human Ubiquitin carboxyl-terminal hydrolase 8 (USP8) | Descriptor: | Ubiquitin carboxyl-terminal hydrolase 8 | Authors: | Walker, J.R, Avvakumov, G.V, Xue, S, Newman, E.M, Mackenzie, F, Weigelt, J, Sundstrom, M, Arrowsmith, C, Edwards, E, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC) | Deposit date: | 2005-07-12 | Release date: | 2005-08-16 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Amino-terminal Dimerization, NRDP1-Rhodanese Interaction, and Inhibited Catalytic Domain Conformation of the Ubiquitin-specific Protease 8 (USP8). J.Biol.Chem., 281, 2006
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1Z4R
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![BU of 1z4r by Molmil](/molmil-images/mine/1z4r) | Human GCN5 Acetyltransferase | Descriptor: | ACETYL COENZYME *A, General control of amino acid synthesis protein 5-like 2 | Authors: | Dong, A, Bernstein, G, Schuetz, A, Antoshenko, T, Wu, H, Loppnau, P, Sundstrom, M, Arrowsmith, C, Edwards, A, Bochkarev, A, Plotnikov, A, Structural Genomics Consortium (SGC) | Deposit date: | 2005-03-16 | Release date: | 2005-03-29 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.74 Å) | Cite: | Crystal structure of a binary complex between human GCN5 histone acetyltransferase domain and acetyl coenzyme A Proteins, 68, 2007
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2A1X
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![BU of 2a1x by Molmil](/molmil-images/mine/2a1x) | Human phytanoyl-coa 2-hydroxylase in complex with iron and 2-oxoglutarate | Descriptor: | 2-OXOGLUTARIC ACID, FE (II) ION, Phytanoyl-CoA dioxygenase | Authors: | Kavanagh, K.L, McDonough, M.A, Searles, T, Butler, D, Bunkoczi, G, von Delft, F, Edwards, A, Arrowsmith, C, Sundstrom, M, Schofield, C.J, Oppermann, U, Structural Genomics Consortium (SGC) | Deposit date: | 2005-06-21 | Release date: | 2005-08-16 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structure of Human Phytanoyl-CoA 2-Hydroxylase Identifies Molecular Mechanisms of Refsum Disease J.Biol.Chem., 280, 2005
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2NPT
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![BU of 2npt by Molmil](/molmil-images/mine/2npt) | Crystal Structure of the complex of human mitogen activated protein kinase kinase 5 phox domain (MAP2K5-phox) with human mitogen activated protein kinase kinase kinase 2 phox domain (MAP3K2-phox) | Descriptor: | Dual specificity mitogen-activated protein kinase kinase 5, Mitogen-activated protein kinase kinase kinase 2 | Authors: | Filippakopoulos, P, Debreczeni, J, Papagrigoriou, V, Turnbull, A, Edwards, A, Arrowsmith, C, Sundstrom, M, von Delft, F, Knapp, S, Structural Genomics Consortium (SGC) | Deposit date: | 2006-10-30 | Release date: | 2006-11-28 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Crystal Structure of the complex of human mitogen activated protein kinase kinase 5 phox domain (MAP2K5-phox) with human mitogen activated protein kinase kinase kinase 2 phox domain (MAP3K2-phox) To be Published
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2L12
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![BU of 2l12 by Molmil](/molmil-images/mine/2l12) | Solution NMR structure of the chromobox protein 7 with H3K9me3 | Descriptor: | Chromobox homolog 7, Histone H3 | Authors: | Kaustov, L, Lemak, A, Gutmanas, A, Fares, C, Quang, H, Loppnau, P, Min, J, Edwards, A, Arrowsmith, C, Structural Genomics Consortium (SGC) | Deposit date: | 2010-07-22 | Release date: | 2010-08-04 | Last modified: | 2020-02-05 | Method: | SOLUTION NMR | Cite: | Recognition and specificity determinants of the human cbx chromodomains. J.Biol.Chem., 286, 2011
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2ARY
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![BU of 2ary by Molmil](/molmil-images/mine/2ary) | Catalytic domain of Human Calpain-1 | Descriptor: | BETA-MERCAPTOETHANOL, CALCIUM ION, Calpain-1 catalytic subunit | Authors: | Walker, J.R, Davis, T, Lunin, V, Newman, E.M, Mackenzie, F, Weigelt, J, Sundstrom, M, Arrowsmith, C, Edwards, A, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC) | Deposit date: | 2005-08-22 | Release date: | 2005-08-30 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | The Crystal Structures of Human Calpains 1 and 9 Imply Diverse Mechanisms of Action and Auto-inhibition J.Mol.Biol., 366, 2007
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2L11
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![BU of 2l11 by Molmil](/molmil-images/mine/2l11) | Solution NMR structure of the Cbx3 in complex with H3K9me3 peptide | Descriptor: | Chromobox protein homolog 3, Histone H3 | Authors: | Kaustov, L, Lemak, A, Fares, C, Gutmanas, A, Quang, H, Loppnau, P, Min, J, Edwards, A, Arrowsmith, C, Structural Genomics Consortium (SGC) | Deposit date: | 2010-07-22 | Release date: | 2010-08-04 | Last modified: | 2020-02-05 | Method: | SOLUTION NMR | Cite: | Recognition and specificity determinants of the human cbx chromodomains. J.Biol.Chem., 286, 2011
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2L1B
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![BU of 2l1b by Molmil](/molmil-images/mine/2l1b) | Solution NMR structure of the chromobox protein Cbx7 with H3K27me3 | Descriptor: | Chromobox protein homolog 7, Histone H3 | Authors: | Kaustov, L, Lemak, A, Fares, C, Gutmanas, A, Muhandiram, R, Quang, H, Loppnau, P, Min, J, Edwards, A, Arrowsmith, C, Structural Genomics Consortium (SGC) | Deposit date: | 2010-07-27 | Release date: | 2010-08-25 | Last modified: | 2020-02-05 | Method: | SOLUTION NMR | Cite: | Recognition and specificity determinants of the human cbx chromodomains. J.Biol.Chem., 286, 2011
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2LC3
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![BU of 2lc3 by Molmil](/molmil-images/mine/2lc3) | Solution NMR structure of a helical bundle domain from human E3 ligase HECTD1. Northeast structural genomics consortium (NESG) target HT6305A | Descriptor: | E3 ubiquitin-protein ligase HECTD1 | Authors: | Lemak, A, Yee, A, Houliston, S, Garcia, M, Arrowsmith, C, Dhe-Paganon, S, Montelione, G.T, Northeast Structural Genomics Consortium (NESG), Structural Genomics Consortium (SGC) | Deposit date: | 2011-04-15 | Release date: | 2011-06-22 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | NMR solution structure of a helical bundle from the E3 ligase HECTD1 To be Published
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2LKI
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![BU of 2lki by Molmil](/molmil-images/mine/2lki) | Solution NMR structure of holo acyl carrier protein NE2163 from nitrosomonas europaea. Northeast structural genomics consortium target NET1. | Descriptor: | 4'-PHOSPHOPANTETHEINE, Putative uncharacterized protein | Authors: | Lemak, A, Srisailam, S, Lukin, J, Yee, A, Montecchio, M, Semesi, A, Arrowsmith, C, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2011-10-11 | Release date: | 2011-11-16 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | Solution structure of acyl carrier protein from Nitrosomonas Europaea Proteins, 64, 2006
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