1YV5

Human farnesyl diphosphate synthase complexed with Mg and risedronate

Summary for 1YV5

• Entry DOI: 10.2210/pdb1yv5/pdb
• Related: 1YQ7
• Descriptor: Farnesyl pyrophosphate synthetase, MAGNESIUM ION, PHOSPHATE ION, ... (5 entities in total)
• Functional Keywords: isoprenoid pathway, cholesterol synthesis, bisphosphonate, structural genomics, structural genomics consortium, sgc, transferase
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: P14324
• Total number of polymer chains: 1
• Total formula weight: 43559.75

Authors

Kavanagh, K.L.,Guo, K.,Von Delft, F.,Arrowsmith, C.,Sundstrom, M.,Edwards, A.,Oppermann, U.,Structural Genomics Consortium (SGC) (deposition date: 2005-02-15, release date: 2005-03-01, Last modification date: 2023-10-25)

• Primary citation: Kavanagh, K.L.,Guo, K.,Dunford, J.E.,Wu, X.,Knapp, S.,Ebetino, F.H.,Rogers, M.J.,Russell, R.G.,Oppermann, U.; The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs.; Proc.Natl.Acad.Sci.USA, 103:7829-7834, 2006; PubMed: 16684881; DOI: 10.1073/pnas.0601643103

Experimental method

X-RAY DIFFRACTION (2 Å)