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PDB: 98 results

4H8I
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BU of 4h8i by Molmil
Structure of GluK2-LBD in complex with GluAzo
Descriptor: (4R)-4-[(2E)-3-{4-[(E)-phenyldiazenyl]phenyl}prop-2-en-1-yl]-L-glutamic acid, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHLORIDE ION, ...
Authors:Reiter, A, Skerra, A, Trauner, D, Schiefner, A.
Deposit date:2012-09-22
Release date:2013-09-25
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:A photoswitchable neurotransmitter analogue bound to its receptor.
Biochemistry, 52, 2013
4GRX
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BU of 4grx by Molmil
Structure of an omega-aminotransferase from Paracoccus denitrificans
Descriptor: Aminotransferase, DELTA-AMINO VALERIC ACID, SODIUM ION
Authors:Rausch, C, Lerchner, A, Schiefner, A, Skerra, A.
Deposit date:2012-08-27
Release date:2012-12-19
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure of the omega-aminotransferase from Paracoccus denitrificans and its phylogenetic relationship with other class III aminotransferases that have biotechnological potential.
Proteins, 81, 2013
3DDY
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BU of 3ddy by Molmil
Structure of lumazine protein, an optical transponder of luminescent bacteria
Descriptor: Lumazine protein, RIBOFLAVIN
Authors:Chatwell, L, Illarionova, V, Illarionov, B, Skerra, A, Bacher, A, Fischer, M.
Deposit date:2008-06-07
Release date:2008-07-01
Last modified:2024-05-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of lumazine protein, an optical transponder of luminescent bacteria.
J.Mol.Biol., 382, 2008
4GH7
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BU of 4gh7 by Molmil
Crystal structure of Anticalin N7A in complex with oncofetal fibronectin fragment Fn7B8
Descriptor: Fibronectin, Neutrophil gelatinase-associated lipocalin
Authors:Schiefner, A, Gebauer, M, Skerra, A.
Deposit date:2012-08-07
Release date:2012-12-26
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Combinatorial design of an Anticalin directed against the extra-domain b for the specific targeting of oncofetal fibronectin
J.Mol.Biol., 425, 2013
4MVK
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BU of 4mvk by Molmil
Crystal structure of an engineered lipocalin (Anticalin US7) in complex with the Alzheimer amyloid peptide fragment VFFAED
Descriptor: Amyloid peptide fragment VFFAED, Neutrophil gelatinase-associated lipocalin
Authors:Eichinger, A, Skerra, A.
Deposit date:2013-09-24
Release date:2015-08-12
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:High-affinity Anticalins with aggregation-blocking activity directed against the Alzheimer beta-amyloid peptide.
Biochem.J., 473, 2016
1XKI
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BU of 1xki by Molmil
Crystal structure of human tear lipocalin/von Ebners gland protein
Descriptor: CHLORIDE ION, Von Ebner's gland protein, ZINC ION
Authors:Breustedt, D.A, Korndoerfer, I.P, Redl, B, Skerra, A.
Deposit date:2004-09-29
Release date:2004-10-19
Last modified:2024-05-29
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The 1.8-A crystal structure of human tear lipocalin reveals an extended branched cavity with capacity for multiple ligands
J.Biol.Chem., 280, 2005
1XK4
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BU of 1xk4 by Molmil
Crystal structure of human calprotectin(S100A8/S100A9)
Descriptor: CALCIUM ION, CHLORIDE ION, CITRATE ANION, ...
Authors:Korndoerfer, I.P, Brueckner, F, Skerra, A.
Deposit date:2004-09-26
Release date:2005-10-18
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The crystal structure of the human (S100A8/S100A9)2 heterotetramer, calprotectin, illustrates how conformational changes of interacting alpha-helices can determine specific association of two EF-hand proteins
J.Mol.Biol., 370, 2007
4MVL
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BU of 4mvl by Molmil
Crystal structure of an engineered lipocalin (Anticalin H1GA) in complex with the Alzheimer amyloid peptide Abeta1-40
Descriptor: Beta-amyloid protein 40, Neutrophil gelatinase-associated lipocalin
Authors:Eichinger, A, Skerra, A.
Deposit date:2013-09-24
Release date:2015-08-12
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:High-affinity Anticalins with aggregation-blocking activity directed against the Alzheimer beta-amyloid peptide.
Biochem.J., 473, 2016
4HH8
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BU of 4hh8 by Molmil
Crystal structure of bovine butyrophilin
Descriptor: Butyrophilin subfamily 1 member A1
Authors:Eichinger, A, Skerra, A.
Deposit date:2012-10-09
Release date:2013-11-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The extracellular region of bovine butyrophilin exhibits high structural similarity to human myelin oligodendrocyte glycoprotein
To be Published
4MVI
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BU of 4mvi by Molmil
Crystal structure of an engineered lipocalin (Anticalin US7) in complex with the Alzheimer amyloid peptide Abeta(1-40)
Descriptor: Beta-amyloid protein 40, Neutrophil gelatinase-associated lipocalin
Authors:Eichinger, A, Skerra, A.
Deposit date:2013-09-24
Release date:2015-08-12
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:High-affinity Anticalins with aggregation-blocking activity directed against the Alzheimer beta-amyloid peptide.
Biochem.J., 473, 2016
6S8V
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BU of 6s8v by Molmil
Structure of the high affinity Anticalin P3D11 in complex with the human CD98 heavy chain ectodomain
Descriptor: 1,2-ETHANEDIOL, 4F2 cell-surface antigen heavy chain, Neutrophil gelatinase-associated lipocalin
Authors:Schiefner, A, Deuschle, F.-C, Skerra, A.
Deposit date:2019-07-10
Release date:2020-03-04
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Development of a high affinity Anticalin®directed against human CD98hc for theranostic applications.
Theranostics, 10, 2020
6SUA
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BU of 6sua by Molmil
Structure of the high affinity engineered lipocalin C1B12 in complex with the mouse CD98 heavy chain ectodomain
Descriptor: 4F2 cell-surface antigen heavy chain, Neutrophil gelatinase-associated lipocalin, SULFATE ION
Authors:Schiefner, A, Deuschle, F.-C, Skerra, A.
Deposit date:2019-09-13
Release date:2020-06-17
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Design of a surrogate Anticalin protein directed against CD98hc for preclinical studies in mice.
Protein Sci., 29, 2020
3DSZ
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BU of 3dsz by Molmil
Engineered human lipocalin 2 in complex with Y-DTPA
Descriptor: N-{(1S,2S)-2-[bis(carboxymethyl)amino]cyclohexyl}-N-{(2R)-2-[bis(carboxymethyl)amino]-3-[4-({[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]carbamothioyl}amino)phenyl]propyl}glycine, YTTRIUM (III) ION, engineered human lipocalin 2
Authors:Eichinger, A, Skerra, A.
Deposit date:2008-07-14
Release date:2009-05-19
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (2 Å)
Cite:High-affinity recognition of lanthanide(III) chelate complexes by a reprogrammed human lipocalin 2
J.Am.Chem.Soc., 131, 2009
3DTQ
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BU of 3dtq by Molmil
Engineered human lipocalin 2 with specificity for Y-DTPA, apo-form
Descriptor: Neutrophil gelatinase-associated lipocalin
Authors:Eichinger, A, Skerra, A.
Deposit date:2008-07-15
Release date:2009-05-12
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:High-affinity recognition of lanthanide(III) chelate complexes by a reprogrammed human lipocalin 2.
J.Am.Chem.Soc., 131, 2009
4QAE
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BU of 4qae by Molmil
Crystal structure of an engineered lipocalin (Anticalin) in complex with human hepcidin
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, CHLORIDE ION, Hepcidin, ...
Authors:Giese, T, Skerra, A.
Deposit date:2014-05-04
Release date:2015-05-06
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure of a hepcidin-binding anticalin in complex with its peptide ligand
To be Published
3BX8
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BU of 3bx8 by Molmil
Engineered Human Lipocalin 2 (LCN2), apo-form
Descriptor: 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL, ENGINEERED HUMAN LIPOCALIN 2, PENTAETHYLENE GLYCOL
Authors:Schonfeld, D.L, Chatwell, L, Skerra, A.
Deposit date:2008-01-11
Release date:2009-01-20
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2 Å)
Cite:High affinity molecular recognition and functional blockade of CTLA-4 by an engineered human lipocalin
To be Published
3BX7
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BU of 3bx7 by Molmil
Engineered Human Lipocalin 2 (LCN2) in Complex with the Extracellular Domain of Human CTLA-4
Descriptor: CYTOTOXIC T-LYMPHOCYTE-ASSOCIATED ANTIGEN 4, ENGINEERED HUMAN LIPOCALIN 2
Authors:Schonfeld, D.L, Chatwell, L, Skerra, A.
Deposit date:2008-01-11
Release date:2009-01-20
Last modified:2024-10-09
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:High affinity molecular recognition and functional blockade of CTLA-4 by an engineered human lipocalin
To be Published
1PKO
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BU of 1pko by Molmil
Myelin Oligodendrocyte Glycoprotein (MOG)
Descriptor: Myelin Oligodendrocyte Glycoprotein
Authors:Breithaupt, C, Schubart, A, Zander, H, Skerra, A, Huber, R, Linington, C, Jacob, U.
Deposit date:2003-06-06
Release date:2003-07-15
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Structural insights into the antigenicity of myelin oligodendrocyte glycoprotein
Proc.Natl.Acad.Sci.USA, 100, 2003
1KL5
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BU of 1kl5 by Molmil
an engineered streptavidin with improved affinity for the strep-tag II peptide : SAm2-StrepII
Descriptor: strep-tag II, streptavidin
Authors:Korndoerfer, I.P, Skerra, A.
Deposit date:2001-12-11
Release date:2002-04-03
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Improved affinity of engineered streptavidin for the Strep-tag II peptide is due to a fixed open conformation of the lid-like loop at the binding site.
Protein Sci., 11, 2002
3QKG
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BU of 3qkg by Molmil
Crystal structure of alpha-1-microglobulin at 2.3 A resolution
Descriptor: GLYCEROL, NICKEL (II) ION, Protein AMBP
Authors:Meining, W, Skerra, A.
Deposit date:2011-02-01
Release date:2012-02-08
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The crystal structure of human alpha(1)-microglobulin reveals a potential haem-binding site.
Biochem.J., 445, 2012
4QAF
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BU of 4qaf by Molmil
Crystal structure of an engineered lipocalin (Anticalin) in complex with VEGF(8-109)
Descriptor: 10-{(1R,2R)-2-[(2E)-hex-2-en-1-yl]cyclopropyl}decanoic acid, ACETATE ION, Lipocalin-1, ...
Authors:Giese, T, Skerra, A.
Deposit date:2014-05-04
Release date:2015-05-06
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of an Anticalin with specific blocking activity towards human vascular endothelial growth factor (VEGF) reveals plasticity of the lipocalin fold
To be Published
1PKQ
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BU of 1pkq by Molmil
Myelin Oligodendrocyte Glycoprotein-(8-18C5) Fab-complex
Descriptor: (8-18C5) chimeric Fab, heavy chain, light chain, ...
Authors:Breithaupt, C, Schubart, A, Zander, H, Skerra, A, Huber, R, Linington, C, Jacob, U.
Deposit date:2003-06-06
Release date:2003-07-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural insights into the antigenicity of myelin oligodendrocyte glycoprotein
Proc.Natl.Acad.Sci.USA, 100, 2003
5N48
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BU of 5n48 by Molmil
Structure of Anticalin N9B in complex with extra-domain B of human oncofetal fibronectin
Descriptor: Fibronectin, Neutrophil gelatinase-associated lipocalin
Authors:Schiefner, A, Skerra, A.
Deposit date:2017-02-10
Release date:2018-02-14
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Anticalins Reveal High Plasticity in the Mode of Complex Formation with a Common Tumor Antigen.
Structure, 26, 2018
5N47
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BU of 5n47 by Molmil
Structure of Anticalin N7E in complex with the three-domain fragment Fn7B8 of human oncofetal fibronectin
Descriptor: Fibronectin, Neutrophil gelatinase-associated lipocalin
Authors:Schiefner, A, Skerra, A.
Deposit date:2017-02-10
Release date:2018-02-14
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (3 Å)
Cite:Anticalins Reveal High Plasticity in the Mode of Complex Formation with a Common Tumor Antigen.
Structure, 26, 2018
5N5V
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BU of 5n5v by Molmil
Structure of p-boronophenylalanyl tRNA synthetase - apo form
Descriptor: CHLORIDE ION, Tyrosine--tRNA ligase
Authors:Schiefner, A, Skerra, A.
Deposit date:2017-02-14
Release date:2018-02-14
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural Basis for the Specific Cotranslational Incorporation of p-Boronophenylalanine into Biosynthetic Proteins.
Biochemistry, 57, 2018

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